| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Curcumin | 📋 | ✍ | ⛔ | | 38699839 | The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38654472 | Cannabidiol attenuates seizure susceptibility and behavioural deficits in adult CDKL5R59X knock-in mice |
| Melatonin | 📋 | ✍ | ⛔ | | 38683122 | Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38684734 | Resveratrol and 1,25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic benefits |
| Resveratrol | 📋 | ✍ | ⛔ | | 38684734 | Resveratrol and 1,25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic benefits |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38705107 | Synergistic promotion of angiogenesis after intracerebral hemorrhage by ginsenoside Rh2 and chrysophanol in rats |
| Quercetin | 📋 | ✍ | ⛔ | | 38696687 | Quercetin Exerts Anticonvulsant Effect through Mitigation of Neuroinflammatory Response in Pentylenetetrazole-induced Seizure in Mice |
| Berberine | 📋 | ✍ | ⛔ | | 38727934 | Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38678615 | Omega-3 polyunsaturated fatty acids play a protective role in a mouse model of Parkinson's disease by increasing intestinal inducible Treg cells |
| EGCG | 📋 | ✍ | ⛔ | | 38732012 | EGCG Disrupts the LIN28B/Let-7 Interaction and Reduces Neuroblastoma Aggressiveness |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38654507 | Ginkgo biloba and Its Chemical Components in the Management of Alzheimer's Disease |
| Metformin | 📋 | ✍ | ⛔ | | 38582410 | The role of the cholinergic system in the memory-protecting effects of metformin in a model of scopolamine-induced memory impairment in aged rats |
| Vitamin C | 📋 | ✍ | ⛔ | | 38718917 | Ascorbic acid supplementation improves adolescent stress-induced cognitive impairment through restoration of behavioral, biochemical and electrophysiological alterations in male rats |
| Ginseng | 📋 | ✍ | ⛔ | | 38707644 | Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 38647358 | The beneficial effect of α-lipoic acid on spinal cord injury repair in rats is mediated through inhibition of oxidative stress: A transcriptomic analysis |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 38169018 | The neuropsychopharmacology of acetyl-L-carnitine (LAC): basic, translational and therapeutic implications |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 38715940 | Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice |
| CoQ10 | 📋 | ✍ | ⛔ | | 38693965 | Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10 |
| Citicoline | 📋 | ✍ | ⛔ | | 38432442 | Additive anxiolytic-like effect of citicoline and ACPA in the non-acute restraint stress (NARS) and acute restraint stress (ARS) mice |
| Luteolin | 📋 | ✍ | ⛔ | | 38682220 | Pharmacotherapeutic Potential of Bitter Gourd (Momordica charantia) in Age-related Neurological Diseases |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38542737 | The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans: A Critical Review |
| Vitamin E | 📋 | ✍ | ⛔ | | 38249609 | Dietary vitamin E intake and risk of Parkinson's disease: a cross-sectional study |
| Astragalosides | 📋 | ✍ | ⛔ | | 38461631 | Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway |
| Magnesium | 📋 | ✍ | ⛔ | | 38514031 | Early intravenous magnesium sulfate and its impact on cerebral vasospasm as well as delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: A retrospective matched case-control analysis |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 38676880 | Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38438062 | Sulforaphane's role in Redefining autophagic Responses in depression associated with polycystic ovarian syndrome: Unveiling the SIRT1/AMPK/LKB1 pathway connection |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 38641841 | Comparison of therapeutic effects of N-Acetylcysteine with pregabalin in improving the clinical symptoms of painful diabetic neuropathy: a randomized, double-blind clinical trial |
| Saffron | 📋 | ✍ | ⛔ | | 38341114 | Saffron (Crocus sativus L.) extract attenuates chronic scopolamine-induced cognitive impairment, amyloid beta, and neurofibrillary tangles accumulation in rats |
| Salidroside | 📋 | | | | 38724500 | Salidroside promotes the repair of spinal cord injury by inhibiting astrocyte polarization, promoting neural stem cell proliferation and neuronal differentiation |
| Ashwagandha | 📋 | ✍ | ⛔ | | 38592845 | Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review |
| Crocin | 📋 | ✍ | ⛔ | | 38356604 | Crocin attenuates the lipopolysaccharide-induced neuroinflammation via expression of AIM2 and NLRP1 inflammasome in an experimental model of Parkinson's disease |
| Ginkgolides | 📋 | | | | 38676673 | [Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer's disease] |
| Hesperidin | 📋 | ✍ | ⛔ | | 38423185 | Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster |
| Genistein | 📋 | ✍ | ⛔ | | 38275516 | Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease |
| Puerarin | 📋 | ✍ | ⛔ | | 38516772 | Puerarin attenuates remifentanil‑induced postoperative hyperalgesia via targeting PAX6 to regulate the transcription of TRPV1 |
| Medicinal Plants | 📋 | | | | 38676473 | Nature's Pharmacy: Herbal Interventions in Rheumatoid Arthritis Treatment: A Comprehensive Review |
| Apigenin | 📋 | ✍ | ⛔ | | 38626647 | Targeting TNF-α-induced expression of TTR and RAGE in rheumatoid arthritis: Apigenin's mediated therapeutic approach |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 38617645 | Evaluation of the Binding Mechanism of Dietary Phytochemical, Ellagic Acid, with Human Transferrin: Spectroscopic, Calorimetric, and Computational Approaches Targeting Neurodegenerative Diseases |
| Micronutrients | 📋 | | ⛔ | | 38623983 | Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration |
| Naringenin | 📋 | ✍ | ⛔ | | 38715438 | Naringenin relieves paclitaxel-induced pain by suppressing calcitonin gene-related peptide signalling and enhances the anti-tumour action of paclitaxel |
| Food | 📋 | | | | 38542790 | Lower Multiple Sclerosis Severity Score Is Associated with Higher Adherence to Mediterranean Diet in Subjects with Multiple Sclerosis from Northwestern Italy |
| Thymoquinone | 📋 | | ⛔ | | 38660812 | Thymoquinone ameliorates symptoms of Parkinson's disease in a 6-OHDA rat model by downregulation of miR-204-3p |
| Baicalein | 📋 | ✍ | ⛔ | | 38715318 | Baicalin and baicalein from Scutellaria baicalensis Georgi alleviate aberrant neuronal suppression mediated by GABA from reactive astrocytes |
| Phytochemicals | 📋 | | | | 38519585 | The predictive role of the dietary phytochemical index in relation to the clinical and psychological traits of migraine headaches |
| Baicalin | 📋 | ✍ | ⛔ | | 38715318 | Baicalin and baicalein from Scutellaria baicalensis Georgi alleviate aberrant neuronal suppression mediated by GABA from reactive astrocytes |
| Fisetin | 📋 | ✍ | ⛔ | | 38671908 | The Neuroprotective Flavonoids Sterubin and Fisetin Maintain Mitochondrial Health under Oxytotic/Ferroptotic Stress and Improve Bioenergetic Efficiency in HT22 Neuronal Cells |
| TUDCA | 📋 | ✍ | ⛔ | | 38440398 | Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer's disease |
| Selenium | 📋 | ✍ | ⛔ | | 38707461 | Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38700503 | Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials |
| Lycopene | 📋 | ✍ | ⛔ | | 38054647 | Lycopene Alleviates Chronic Stress-Induced Hippocampal Microglial Pyroptosis by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway |
| Rutin | 📋 | ✍ | ⛔ | | 38408719 | Benefits of rutin on mitochondrial function and inflammation in an aluminum-induced neurotoxicity rat model: Potential interest for the prevention of neurodegeneration |
| Andrographolide | 📋 | | | | 37979090 | Andrographolide inhibits the activation of spinal microglia and ameliorates mechanical allodynia |
| Capsaicin | 📋 | ✍ | ⛔ | | 38344267 | Topical capsaicin 8% patch in peripheral neuropathic pain: Efficacy and quality of life |
| Icariin | 📋 | ✍ | | | 38706972 | Icariin inhibits apoptosis in OGD-induced neurons by regulating M2 pyruvate kinase |
| Chrysin | 📋 | ✍ | ⛔ | | 38538228 | Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study |
| Goji Berry | 📋 | ✍ | ⛔ | | 38653878 | Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer's Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway |
| Caffeine | 📋 | ✍ | ⛔ | | 38513162 | Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 38604452 | The neuroprotective effects of ferulic acid in toxin-induced models of Parkinson's disease: A review |
| Zinc | 📋 | ✍ | ⛔ | | 38707461 | Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack |
| Piperine | 📋 | ✍ | ⛔ | | 38158101 | Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 37494903 | The Use of Lavender Aromatherapy for Pain After Total Hip and Total Knee Arthroplasty: A Randomized Trial |
| NMN | 📋 | ✍ | ⛔ | | 38504592 | NAD+ precursor supplementation modulates neurite complexity and survival in motor neurons from ALS models |
| Fish Oil | 📋 | ✍ | ⛔ | | 38348197 | Fish oil supplementation, physical activity and risk of incident Parkinson's disease: results of longitudinal analysis from the UK Biobank |
| Gotu Kola | 📋 | ✍ | ⛔ | | 38703344 | Hydroalcoholic Extract of Centella asiatica and Madecassic Acid Reverse Depressive-Like Behaviors, Inflammation and Oxidative Stress in Adult Rats Submitted to Stress in Early Life |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 38432716 | Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 38716504 | Grape seed-derived procyanidins decreases neuropathic pain and nerve regeneration by suppression of TLR4-Myd88 signaling |
| Naringin | 📋 | ✍ | ⛔ | | 38457013 | Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia-Reperfusion Model of Rats |
| Pterostilbene | 📋 | ✍ | ⛔ | | 38354494 | Pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male Swiss albino mice and affects insulin resistance, inflammation, HPA axis dysfunction and SIRT1 mediated leptin-ghrelin signaling |
| Polyphenols | 📋 | | | | 38490348 | Dietary polyphenols represent a phytotherapeutic alternative for gut dysbiosis associated neurodegeneration: A Systematic review |
| Nobiletin | 📋 | ✍ | | | 37932838 | A review on recent advances on nobiletin in central and peripheral nervous system diseases |
| Probiotics | 📋 | ✍ | ⛔ | | 38645104 | Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 37712262 | [Dihydromyricetin alleviates pyroptosis and necroptosis in mice with MPTP-induced chronic Parkinson's disease by inducing autophagy] |
| Ginger | 📋 | ✍ | ⛔ | | 38402829 | Ginger alleviates mechanical hypersensitivity and anxio-depressive behavior in rats with diabetic neuropathy through beneficial actions on gut microbiome composition, mitochondria, and neuroimmune cells of colon and spinal cord |
| Paeoniflorin | 📋 | | | | 38726183 | Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012 |
| Carvacrol | 📋 | ✍ | ⛔ | | 38649135 | Neuroprotective role of Carvacrol via Nrf2/HO-1/NLRP3 axis in Rotenone-induced PD mice model |
| Flavonoids | 📋 | | ⛔ | | 38398799 | Effect of Polyphenol Supplementation on Memory Functioning in Overweight and Obese Adults: A Systematic Review and Meta-Analysis |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 38379607 | Black seed oil reverses chronic antibiotic-mediated depression and social behaviour deficits via modulation of hypothalamic mitochondrial-dependent markers and insulin expression |
| Rosmarinic Acid | 📋 | ✍ | | | 38707916 | Rosmarinic acid Ameliorates neuronal regeneration in the bridging silicone rubber conduits of the sciatic nerve in taxol-treated rats |
| Tanshinone | 📋 | | | | 38659601 | Tanshinone IIA improves Alzheimer's disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis |
| Blueberry | 📋 | ✍ | ⛔ | | 38621470 | Anthocyanins from blueberry ameliorated arsenic-induced memory impairment, oxidative stress, and mitochondrial-biosynthesis imbalance in rat hippocampal neurons |
| Fucoidan | 📋 | ✍ | ⛔ | | 38240036 | Ultrastructural and immunohistochemical insights on the anti-glioma effects of a dual-drug cocktail in an in vivo experimental model |
| L-Theanine | 📋 | ✍ | ⛔ | | 38716554 | Inhibitory Role of L-theanine, a Structural Analogue of Glutamate, Against GluR5 Kainate Receptor and its Prospective Utility Against Excitotoxicity |
| Emodin | 📋 | | ⛔ | | 38405501 | Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer's Dementia: A Systematic Review |
| Frankincense | 📋 | ✍ | ⛔ | | 38250661 | Autophagy machinery plays an essential role in traumatic brain injury-induced apoptosis and its related behavioral abnormalities in mice: focus on Boswellia Sacra gum resin |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 38392200 | Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice |
| Oleuropein | 📋 | | | | 38542729 | Olive Oil Components as Novel Antioxidants in Neuroblastoma Treatment: Exploring the Therapeutic Potential of Oleuropein and Hydroxytyrosol |
| Pomegranate | 📋 | | ⛔ | | 38074891 | A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease |
| Schisandra | 📋 | ✍ | ⛔ | | 38565361 | Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice |
| Kaempferol | 📋 | ✍ | ⛔ | | 38587532 | Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice |
| Silymarin | 📋 | ✍ | ⛔ | | 38353101 | Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease |
| Allicin | 📋 | ✍ | ⛔ | | 37973218 | Therapeutic effect of allicin in a mouse model of intracerebral hemorrhage |
| Hydroxytyrosol | 📋 | | | | 38680105 | Hydroxytyrosol ameliorates stress-induced liver injury through activating autophagy via HDAC1/2 inhibition |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 38680120 | Eicosapentaenoic acid activates the P62/KEAP1/NRF2 pathway for the prevention of diabetes-associated cognitive dysfunction |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 38453099 | Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1/2-dependent pathways |
| Antioxidants | 📋 | | ⛔ | | 38578890 | Association Between Composite Dietary Antioxidant Index and Cognitive Function Among Aging Americans from NHANES 2011-2014 |
| Mangiferin | 📋 | | ⛔ | | 38305392 | Neuroprotective Effects of Isolated Mangiferin from Swertia chirayita Leaves Regulating Oxidative Pathway on Streptozotocin-Induced Diabetic Neuropathy in Experimental Rats |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 38625552 | Neuroprotective effects of chlorogenic acid against oxidative stress in rats subjected to lithium-pilocarpine-induced status epilepticus |
| Folate | 📋 | ✍ | ⛔ | | 37735121 | Features of Plasma Homocysteine, Vitamin B12, and Folate in Parkinson's Disease: An Updated Meta-Analysis |
| Gallic Acid | 📋 | | ⛔ | | 38549642 | Gallic Acid Alleviates Cognitive Impairment by Promoting Neurogenesis via the GSK3β-Nrf2 Signaling Pathway in an APP/PS1 Mouse Model |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 38455639 | Moringa oleifera leaves ethanolic extract counteracts cortical neurodegeneration induced by aluminum chloride in rats |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 38720773 | Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease |
| Bee Venom | 📋 | ✍ | ⛔ | | 38414737 | Melittin promotes dexamethasone in the treatment of adjuvant rheumatoid arthritis in rats |
| Carnosic Acid | 📋 | | | | 38538219 | Brain Mitochondria as a Therapeutic Target for Carnosic Acid |
| Salvianolic Acid | 📋 | | | | 38468280 | Salvianolic acid C attenuates cerebral ischemic injury through inhibiting neuroinflammation via the TLR4-TREM1-NF-κB pathway |
| Hesperetin | 📋 | | | | 38556120 | Hesperetin ameliorates spinal cord injury in rats through suppressing apoptosis, oxidative stress and inflammatory response |
| Licorice Root | 📋 | ✍ | ⛔ | | 38092318 | Exploring the efficacy and mechanism of Glycyrrhizae Radix et Rhizoma in improving collagen-induced arthritis in mice |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 38563150 | Exploring the immune-modulating properties of boswellic acid in experimental autoimmune encephalomyelitis |
| Coconut Oil | 📋 | | ⛔ | | 38243570 | Neuroprotective Effects of Virgin Coconut Oil Supplemented Diet against Sodium Benzoate-induced Acetylcholinesterase Dysfunction and Cognitive Impairment: Role of Nrf2/NfKb Signaling Pathway |
| Geniposide | 📋 | | | | 38402902 | Geniposide ameliorates brain injury in mice with intracerebral hemorrhage by inhibiting NF-κB signaling |
| L-Carnitine | 📋 | ✍ | ⛔ | | 38674921 | L-Carnitine in the Treatment of Psychiatric and Neurological Manifestations: A Systematic Review |
| Olive Oil | 📋 | ✍ | ⛔ | | 38709531 | Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death |
| Rapamycin | 📋 | ✍ | | | 38640155 | Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies |
| Silibinin | 📋 | ✍ | | | 37981056 | Evaluating the toxic mechanism of 1,2-diacetylbenzene in neural cells/tissues: the favorable impact of silibinin |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 38684848 | St. John's wort extract Ze 117 alters the membrane fluidity of C6 glioma cells by influencing cellular cholesterol metabolism |
| Taurine | 📋 | ✍ | ⛔ | | 38693965 | Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10 |
| Asiatic Acid | 📋 | | | | 38477392 | Asiatic acid inhibits rheumatoid arthritis fibroblast-like synoviocyte growth through the Nrf2/HO-1/NF-κB signaling pathway |
| Cinnamon | 📋 | ✍ | ⛔ | | 38696678 | Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38495146 | Prolonged oral intake of green tea polyphenols attenuates delirium-like behaviors in mice induced by anesthesia/surgery |
| Green Tea | 📋 | ✍ | ⛔ | | 38706293 | Investigating the Impact of Tea Consumption on Cognitive Function and Exploring Tea-Genetic Interactions in Older Adults Aged 65-105 Years: Findings from the 2002-2018 CLHLS Data |
| PEA | 📋 | ✍ | ⛔ | | 38533175 | The Comparative Efficacy of Palmitoylethanolamide (PEA) With the Combination of Pregabalin and Nortriptyline on Post-extraction Trigeminal Neuropathy by Using Magnetic Resonance (MR) Neurography: A Randomized Clinical Trial |
| Catalpol | 📋 | | | | 38522312 | Catalpol attenuates ischemic stroke by promoting neurogenesis and angiogenesis via the SDF-1α/CXCR4 pathway |
| Formononetin | 📋 | | | | 37944786 | Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3 |
| Gingerol | 📋 | ✍ | | | 38397589 | Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 38153337 | Expression of Na+/Ca2+ exchangers were enhanced following pre-treatment of olive leaf extract and olive oil in animal model of ischemic stroke |
| Spirulina | 📋 | ✍ | ⛔ | | 37773524 | Antioxidant and anti-inflammatory potential of spirulina and thymoquinone mitigate the methotrexate-induced neurotoxicity |
| Urolithins | 📋 | | | | 38587058 | Urolithin A attenuates bupivacaine-induced neurotoxicity in SH-SY5Y cells by regulating the SIRT1-activated PI3K/AKT pathway |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 38601615 | Association of vitamin B1 intake with geriatric cognitive function: An analysis of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014 |
| Walnut | 📋 | | ⛔ | | 37764868 | Isolation, Identification, Activity Evaluation, and Mechanism of Action of Neuroprotective Peptides from Walnuts: A Review |
| Astragalus Root | 📋 | ✍ | ⛔ | | 38504529 | Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials |
| Cocoa | 📋 | ✍ | ⛔ | | 38244989 | Effect of multivitamin-mineral supplementation versus placebo on cognitive function: Results from the clinic sub-cohort of the COSMOS randomized clinical trial and meta-analysis of three cognitive studies within COSMOS |
| Coffee | 📋 | ✍ | ⛔ | | 38714417 | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| Galangin | 📋 | | | | 38557656 | Analgesic and anti-inflammatory effects of galangin: a potential pathway to inhibit transient receptor potential vanilloid 1 receptor activation |
| Vitamin B Complex | 📋 | | ⛔ | | 38679671 | Enhancing nerve regeneration in infraorbital nerve injury rat model: effects of vitamin B complex and photobiomodulation |
| Aged Garlic | 📋 | ✍ | ⛔ | | 35805955 | Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease |
| Bee Propolis | 📋 | ✍ | ⛔ | | 38583392 | Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 37965135 | Fucoxanthin ameliorates traumatic brain injury by suppressing the blood-brain barrier disruption |
| Spikenard | 📋 | ✍ | ⛔ | | 37559448 | Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways |
| Arctigenin | 📋 | | | | 38104254 | Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 38553964 | Bergamot essential oil improves CUMS-induced depression-like behaviour in rats by protecting the plasticity of hippocampal neurons |
| Catechins | 📋 | | | | 38235046 | Therapeutic Potential of Catechin as an IKK-β Inhibitor for the Management of Arthritis: In vitro and In vivo Approach |
| Essential Oils | 📋 | | ⛔ | | 38397776 | Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 38387425 | The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats |
| Angelica | 📋 | ✍ | ⛔ | | 37322622 | Angelica sinensis extract induces telomere dysfunction, cell cycle arrest, and mitochondria-mediated apoptosis in human glioblastoma cells |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 38671841 | Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis |
| Carotenoids | 📋 | ✍ | ⛔ | | 37502714 | The protective effect of serum carotenoids on cardiovascular disease: a cross-sectional study from the general US adult population |
| L-Carnosine | 📋 | ✍ | ⛔ | | 37063279 | Microfluidic/HPLC combination to study carnosine protective activity on challenged human microglia: Focus on oxidative stress and energy metabolism |
| Pine Bark | 📋 | ✍ | ⛔ | | 36153882 | Pycnogenol® supplementation alleviates symptoms of Parkinson's disease with mild cognitive impairment |
| Punicalagin | 📋 | ✍ | ⛔ | | 37896179 | Punicalagin's Protective Effects on Parkinson's Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 38570065 | Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain |
| Asiaticoside | 📋 | | | | 38471370 | Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation |
| Dihydroquercetin | 📋 | | | | 38723817 | Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation |
| Honokiol | 📋 | | | | 38388224 | Honokiol hexafluoro confers reversal of neuropathological markers of HIV infection in a murine SCID model |
| Isoliquiritigenin | 📋 | | | | 38395608 | Isoliquiritigenin attenuates neuroinflammation after subarachnoid hemorrhage through inhibition of NF-κB-mediated NLRP3 inflammasome activation |
| Ligustilide | 📋 | | | | 38021448 | Anti-Glioma Effects of Ligustilide or n-Butylphthalide on Their Own and the Synergistic Effects with Temozolomide via PI3K/Akt Signaling Pathway |
| Lutein | 📋 | ✍ | ⛔ | | 38487969 | Lutein and the Underlying Neuroprotective Promise against Neurodegenerative Diseases |
| Mulberry | 📋 | | ⛔ | | 38612872 | Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays |
| Valerian Root | 📋 | ✍ | ⛔ | | 36829235 | Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 38204302 | Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study |
| Anthocyanins | 📋 | ✍ | ⛔ | | 38455191 | Higher anthocyanin intake is associated with lower depressive symptoms in adults with and without major depressive disorder |
| Artemisinin | 📋 | | | | 38454322 | Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice |
| Crocetin | 📋 | | | | 38433503 | Crocetin protects mouse brain from apoptosis in traumatic brain injury model through activation of autophagy |
| Diosmin | 📋 | ✍ | ⛔ | | 38092305 | Diosmin ameliorates LPS-induced depression-like behaviors in mice: Inhibition of inflammation and oxidative stress in the prefrontal cortex |
| Magnolol | 📋 | | | | 38729444 | Magnolol ameliorates fumonisin B1-induced oxidative damage and lipid metabolism dysfunction in astrocyte-like C6 cells |
| Peony | 📋 | | ⛔ | | 37838295 | Total Glucosides of White Paeony Capsule ameliorates Parkinson's disease-like behavior in MPTP-induced mice model by regulating LRRK2/alpha-synuclein signaling |
| Tangeretin | 📋 | | | | 38672774 | An Update on the Potential of Tangeretin in the Management of Neuroinflammation-Mediated Neurodegenerative Disorders |
| Butyrate | 📋 | | ⛔ | | 38694925 | Buty and the beast: the complex role of butyrate in Parkinson's disease |
| Cinnamaldehyde | 📋 | | | | 38621979 | [Improvement effect of cinnamaldehyde on reserpine-induced Parkinson's disease rat model] |
| Echinacoside | 📋 | | | | 38569512 | Beneficial effects of Echinacoside on cognitive impairment and diabetes in type 2 diabetic db/db mice |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 36159806 | Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders |
| Schisandrins | 📋 | | | | 38551405 | Effects of schisandrin B on hypoxia-related cognitive function and protein expression in vascular dementia rats |
| Skullcap | 📋 | ✍ | ⛔ | | 38645989 | Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer's Disease |
| Turmeric | 📋 | ✍ | ⛔ | | 38027700 | The neuroprotective potential of turmeric rhizome and bitter melon on aspartame-induced spatial memory impairment in rats |
| Bromelain | 📋 | ✍ | ⛔ | | 38075000 | Bromelain regulates TRP channels to induce orofacial nociception relief in adult zebrafish |
| Cordycepin | 📋 | | | | 38479634 | Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation |
| Indian Gooseberry | 📋 | | ⛔ | | 38030098 | Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 37876150 | Dietary Supplement with Tribulus terrestris L. Extract Exhibits Protective Effects on Ischemic Stroke Rats |
| 5-HTP | 📋 | ✍ | ⛔ | | 37421347 | Effects of adjuvant berberine therapy on acute ischemic stroke: A meta-analysis |
| Acai Berry | 📋 | ✍ | ⛔ | | 37584088 | Açai Berry Ameliorates Cognitive Impairment by Inhibiting NLRP3/ASC/CASP axis in STZ-Induced Diabetic Neuropathy in Mice |
| DHEA | 📋 | ✍ | ⛔ | | 38183866 | Cortisol and changes in depressive symptoms: The moderating role of DHEA |
| Eugenol | 📋 | | | | 38681628 | Study on mechanism of transdermal administration of eugenol for pain treatment by network pharmacology and molecular docking technology |
| Lemon Balm | 📋 | ✍ | ⛔ | | 37927585 | The possible "calming effect" of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical trial |
| Myricetin | 📋 | | ⛔ | | 38423257 | Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats |
| Tea | 📋 | | | | 38714417 | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| Trehalose | 📋 | | ⛔ | | 37542649 | Metformin and Trehalose-Modulated Autophagy Exerts a Neurotherapeutic Effect on Parkinson's Disease |
| Vitamin A | 📋 | ✍ | ⛔ | | 38040269 | Supplementation with Vitamins D3 and A Mitigates Parkinsonism in a Haloperidol Mice Model |
| Bilobalide | 📋 | | | | 37802788 | [Mechanism of bilobalide promoting neuroprotection of macrophages] |
| CAPE | 📋 | | | | 38528569 | Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway |
| Choline | 📋 | ✍ | ⛔ | | 37214864 | Low circulating choline, a modifiable dietary factor, is associated with the pathological progression and metabolome dysfunction in Alzheimer's disease |
| Ginger extract | 📋 | ✍ | ⛔ | | 36830967 | Red Ginger Extract Prevents the Development of Oxaliplatin-Induced Neuropathic Pain by Inhibiting the Spinal Noradrenergic System in Mice |
| Holy Basil | 📋 | ✍ | ⛔ | | 37141281 | Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic-pituitary-adrenal (HPA) axis in modulating stress |
| Olive Polyphenols | 📋 | | | | 36364796 | Neuroprotective Panel of Olive Polyphenols: Mechanisms of Action, Anti-Demyelination, and Anti-Stroke Properties |
| Progesterone | 📋 | ✍ | ⛔ | | 37247723 | CISPLATIN AND PROGESTERONE SEPARATE AND COMBINED ACTION ON RAT BRAIN NUCLEAR PHOSPHOLIPIDS CONTENT |
| Rosemary | 📋 | ✍ | ⛔ | | 38258779 | Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies |
| Ganoderic Acid | 📋 | | | | 38723681 | Ganoderic acid A ameliorates depressive-like behaviors in CSDS mice: Insights from proteomic profiling and molecular mechanisms |
| Garlic | 📋 | ✍ | ⛔ | | 38563400 | The association between raw garlic consumption and the risk of depressive symptoms: the TCLSIH cohort study |
| L-Arginine | 📋 | ✍ | ⛔ | | 38430848 | Impact of L-Arginine on diabetes-induced neuropathy and myopathy: Roles of PAI-1, Irisin, oxidative stress, NF-κβ, autophagy and microRNA-29a |
| Licochalcones | 📋 | | | | 37762479 | Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment |
| Linalool | 📋 | | ⛔ | | 38723901 | Linalool acts as a chemical chaperone by inhibiting amyloid-β aggregation |
| Mangosteen | 📋 | ✍ | ⛔ | | 36552604 | Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson's Disease |
| Scutellarin | 📋 | | | | 38684459 | Scutellarin Attenuates Microglia Activation in LPS-Induced BV-2 Microglia via miRNA-7036a/MAPT/PRKCG/ERK Axis |
| Betaine | 📋 | ✍ | ⛔ | | 38184996 | Betaine alleviates cognitive impairment induced by homocysteine through attenuating NLRP3-mediated microglial pyroptosis in an m6A-YTHDF2-dependent manner |
| Coriander | 📋 | | ⛔ | | 37513187 | Coriandrum sativum and Its Utility in Psychiatric Disorders |
| Daidzein | 📋 | ✍ | ⛔ | | 38679467 | Daidzein ameliorates nonmotor symptoms of manganese-induced Parkinsonism in zebrafish model: Behavioural and biochemical approach |
| Escin | 📋 | ✍ | ⛔ | | 37876856 | Deciphering the Molecular Mechanism of Escin against Neuropathic Pain: A Network Pharmacology Study |
| Fish | 📋 | | ⛔ | | 38706279 | Fish and Shellfish Consumption, Cognitive Health and Mortality from Alzheimer's Disease among US Adults Aged 60 and Older |
| Gardenia | 📋 | | ⛔ | | 38301302 | Neuropharmacological insights into Gardenia jasminoides Ellis: Harnessing therapeutic potential for central nervous system disorders |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 38539904 | The Cerebral Protective Effect of Novel Erinacines from Hericium erinaceus Mycelium on In Vivo Mild Traumatic Brain Injury Animal Model and Primary Mixed Glial Cells via Nrf2-Dependent Pathways |
| Paeonol | 📋 | | | | 38036272 | Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/β-arrestin2 and activating the cAMP-PKA signaling pathway in premenstrual irritability rats |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 35164175 | Healthy Properties of a New Formulation of Pomegranate-Peel Extract in Mice Suffering from Experimental Autoimmune Encephalomyelitis |
| Stigmasterol | 📋 | | | | 38572785 | Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R |
| Thymol | 📋 | ✍ | ⛔ | | 37648049 | Thymol abates the detrimental impacts of imidacloprid on rat brains by lessening oxidative damage and apoptotic and inflammatory reactions |
| Aspirin | 📋 | | ⛔ | | 38039031 | Comprehensive systematic review and meta-analysis on anticoagulants and aspirin for stroke prevention in non-valvular atrial fibrillation patients |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 37259308 | Reversal of Neuralgia Effect of Beta Carotene in Streptozotocin-Associated Diabetic Neuropathic Pain in Female Zebrafish via Matrix Metalloprotease-13 Inhibition |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 38229887 | Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease |
| Icaritin | 📋 | | | | 37990437 | Icaritin greatly attenuates β-amyloid-induced toxicity in vivo |
| Mushrooms | 📋 | | ⛔ | | 38474765 | Association between Intake of Edible Mushrooms and Algae and the Risk of Cognitive Impairment in Chinese Older Adults |
| Polydatin | 📋 | ✍ | | | 37947073 | Mechanism Study of Polydatin in Treating Spinal Cord Injury by Modulating Mitochondrial Membrane Potential Based on Network Pharmacology and Molecular Docking |
| Red Sage | 📋 | ✍ | ⛔ | | 38356496 | Protective effect of Danshensu against neurotoxicity induced by monosodium glutamate in adult mice and their offspring |
| Telmisartan | 📋 | | ⛔ | | 38419447 | Telmisartan Protects Mitochondrial Function, Gait, and Neuronal Apoptosis by Activating the Akt/GSK3β/PGC1α Pathway in an MPTP-Induced Mouse Model of Parkinson's Disease |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 37723526 | Dietary niacin intake in relation to depression among adults: a population-based study |
| Wogonin | 📋 | ✍ | ⛔ | | 38552763 | Wogonin inhibits the migration and invasion of fibroblast-like synoviocytes by targeting PI3K/AKT/NF-κB pathway in rheumatoid arthritis |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 38467357 | Zeaxanthin impairs angiogenesis and tumor growth of glioblastoma: An in vitro and in vivo study |
| Acacetin | 📋 | | | | 36590896 | Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38461353 | Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles |
| Creatine | 📋 | ✍ | ⛔ | | 38262563 | Creatine supplementation with exercise reduces α-synuclein oligomerization and necroptosis in Parkinson's disease mouse model |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 37662796 | Efficacy of combination of N-acetylcysteine and primrose in spinal cord injury; an experimental study |
| Grape | 📋 | | ⛔ | | 36613906 | Protective Effects of Currants ( Vitis vinifera) on Corticolimbic Serotoninergic Alterations and Anxiety-like Comorbidity in a Rat Model of Parkinson's Disease |
| Hyperoside | 📋 | | | | 38500281 | Neuroinflammatory Response and Redox-regulation Activity of Hyperoside in Manganese-induced Neurotoxicity Model of Wistar Rats |
| Morin | 📋 | | | | 38423257 | Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats |
| Neferine | 📋 | | | | 38428144 | Nrf2 activation by neferine mitigates microglial neuroinflammation after subarachnoid hemorrhage through inhibiting TAK1-NF-κB signaling |
| Nicotinamide | 📋 | ✍ | ⛔ | | 37663127 | Nicotinamide enhances myelin production after demyelination through reduction of astrogliosis and microgliosis |
| PUFA | 📋 | | | | 37743908 | Causal association of polyunsaturated fatty acids with chronic pain: a two-sample Mendelian randomization study |
| Sesamol | 📋 | | | | 37778247 | Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids |
| Tannic Acid | 📋 | ✍ | ⛔ | | 38455638 | Tannic acid ameliorates the hazards effect of beryllium induced neuro-alterations and oxidative stress in adult male rats |
| Withanolides | 📋 | | | | 35159267 | Effect of Withanolide A on 7-Ketocholesterol Induced Cytotoxicity in hCMEC/D3 Brain Endothelial Cells |
| Wormwood | 📋 | ✍ | ⛔ | | 36999542 | Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation |
| Aloe-Emodin | 📋 | | | | 38122912 | Aloe-emodin from Sanhua Decoction inhibits neuroinflammation by regulating microglia polarization after subarachnoid hemorrhage |
| Andrographis | 📋 | ✍ | ⛔ | | 38057817 | Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway |
| Dandelion | 📋 | ✍ | ⛔ | | 37746960 | External application of dandelion combined with borneol effectively reduced pain and facial swelling after jaw surgery |
| Diosgenin | 📋 | | | | 38288021 | Role of diosgenin extracted from Helicteres isora L in suppression of HIV-1 replication: An in vitro preclinical study |
| Geraniol | 📋 | | | | 38517361 | Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model |
| Irisin | 📋 | | | | 38658376 | Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases |
| Myrrh | 📋 | ✍ | ⛔ | | 38186647 | An aqueous Commiphora myrrha extract ameliorates paclitaxel-induced peripheral neuropathic pain in mice |
| Prebiotics | 📋 | ✍ | ⛔ | | 38519181 | Prebiotics modulate the microbiota-gut-brain axis and ameliorate anxiety and depression-like behavior in HFD-fed mice |
| Aloe Vera | 📋 | ✍ | ⛔ | | 37938932 | Isolation, preparation and investigation of leaf extracts of Aloe barbadensis for its remedial effects on tumor necrosis factor alpha (TNF-α) and interleukin (IL-6) by in vivo and in silico approaches in experimental rats |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 38591965 | Caffeic acid attenuates memory dysfunction and restores the altered activity of cholinergic, monoaminergic and purinergic in brain of cadmium chloride exposure rats |
| Hawthorn | 📋 | ✍ | ⛔ | | 36447359 | Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38474254 | Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature |
| Magnolia | 📋 | ✍ | ⛔ | | 37627513 | Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain |
| NAD | 📋 | | | | 34928817 | NAD+ improved experimental autoimmune encephalomyelitis by regulating SIRT1 to inhibit PI3K/Akt/mTOR signaling pathway |
| Parthenolide | 📋 | | | | 37992573 | Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway |
| PQQ | 📋 | ✍ | ⛔ | | 38454653 | Deep Learning-Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease |
| Pregnenolone | 📋 | ✍ | ⛔ | | 36878398 | Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease |
| Retinoic Acid | 📋 | | | | 38339295 | Retinoid Therapy for Neuroblastoma: Historical Overview, Regulatory Challenges, and Prospects |
| Rhodiola | 📋 | ✍ | ⛔ | | 38398618 | Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review |
| Senolytics | 📋 | | | | 38225896 | Senolytic treatment alleviates doxorubicin-induced chemobrain |
| Strawberry | 📋 | ✍ | ⛔ | | 38003966 | Amelioration of Rheumatoid Arthritis by Fragaria nubicola (Wild Strawberry) via Attenuation of Inflammatory Mediators in Sprague Dawley Rats |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 34202933 | Vitamin K2 Modulates Organelle Damage and Tauopathy Induced by Streptozotocin and Menadione in SH-SY5Y Cells |
| Vitamins | 📋 | | | | 38397800 | A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer's Disease: A Focus on Probiotic and Vitamin Co-Supplementation |
| Biochanin A | 📋 | | | | 38360888 | Exploring the therapeutic mechanisms and prognostic targets of Biochanin A in glioblastoma via integrated computational analysis and in vitro experiments |
| Black Pepper | 📋 | ✍ | ⛔ | | 37237954 | Black Pepper ( Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent against Neurodegenerative Diseases |
| Carnosol | 📋 | | | | 37415927 | Carnosol Alleviates Collagen-Induced Arthritis by Inhibiting Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells |
| Chokeberry | 📋 | ✍ | ⛔ | | 38398826 | The Protective Impact of Aronia melanocarpa L. Berries Extract against Prooxidative Cadmium Action in the Brain-A Study in an In Vivo Model of Current Environmental Human Exposure to This Harmful Element |
| Coptis Chinensis | 📋 | | ⛔ | | 38599826 | Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells |
| Cordyceps | 📋 | ✍ | ⛔ | | 36059969 | Bidirectional regulatory effects of Cordyceps on arrhythmia: Clinical evaluations and network pharmacology |
| Fenugreek | 📋 | ✍ | ⛔ | | 37554151 | Fenugreek seed powder protects mice against arsenic-induced neurobehavioral changes |
| Guggulsterone | 📋 | | | | 38170440 | Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples |
| Royal Jelly | 📋 | ✍ | ⛔ | | 38657030 | Comparative neuroprotective effects of royal jelly and its unique compound 10-hydroxy-2-decenoic acid on ischemia-induced inflammatory, apoptotic, epigenetic and genotoxic changes in a rat model of ischemic stroke |
| Safranal | 📋 | | | | 38683404 | Safranal exerts a neuroprotective effect on Parkinson's disease with suppression of NLRP3 inflammation activation |
| Sesamin | 📋 | ✍ | | | 38141790 | Sesamin mitigates lead-induced behavioral deficits in male rats: The role of oxidative stress |
| Shogaol | 📋 | | | | 37337830 | 6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson's Disease Mouse Model |
| Vitamin K | 📋 | ✍ | ⛔ | | 38621744 | The Role of Vitamin K in the Development of Neurodegenerative Diseases |
| Vitexin | 📋 | | | | 38453699 | Vitexin enhances radiosensitivity of mouse subcutaneous xenograft glioma by affecting the miR-17-5p/miR-130b-3p/PTEN/HIF-1α pathway |
| Withaferin A | 📋 | | | | 36453416 | Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 37344230 | Association of Polyunsaturated Fatty Acids and Clinical Progression in Patients With ALS: Post Hoc Analysis of the EMPOWER Trial |
| Basil | 📋 | ✍ | ⛔ | | 38433659 | Sweet basil ( Ocimum basilicum) leaf and seed extracts alleviate neuronal dysfunction in aluminum chloride-induced neurotoxicity in Drosophila melanogaster Meigen model |
| Calycosin | 📋 | | | | 38461458 | Calycosin (CA) inhibits proliferation, migration and invasion by suppression of CXCL10 signaling pathway in glioma |
| Chondroitin | 📋 | ✍ | ⛔ | | 37016458 | Combined treatment with glucosamine and chondroitin sulfate improves rheumatoid arthritis in rats by regulating the gut microbiota |
| Coumaric acid | 📋 | | | | 38000530 | Protection of p-Coumaric acid against chronic stress-induced neurobehavioral deficits in mice via activating the PKA-CREB-BDNF pathway |
| Cyanidin | 📋 | ✍ | | | 38705400 | Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology by restoring canonical Wnt signaling |
| Dioscin | 📋 | | | | 38518642 | Dioscin decreases M2 polarization via inhibiting a positive feedback loop between RBM47 and NF-κB in glioma |
| Echinacea | 📋 | ✍ | ⛔ | | 36640914 | Evaluation of anti-Alzheimer activity of Echinacea purpurea extracts in aluminum chloride-induced neurotoxicity in rat model |
| Elderberry | 📋 | ✍ | ⛔ | | 38675372 | In Vivo Anti-Inflammatory and Antinociceptive Activities of Black Elder (Sambucus nigra L.) Fruit and Flower Extracts |
| Glucosamine | 📋 | ✍ | ⛔ | | 37689747 | Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population |
| Haritaki | 📋 | ✍ | ⛔ | | 38329710 | Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study |
| Honey | 📋 | ✍ | ⛔ | | 37570596 | Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 36986277 | Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 37485660 | Flavonoids from Seabuckthorn ( Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice |
| Tetrahydrocurcumin | 📋 | ✍ | | | 38368289 | Tetrahydrocurcumin Protects Against GSK3β/PTEN/PI3K/Akt-Mediated Neuroinflammatory Responses and Microglial Polarization Following Traumatic Brain Injury |
| Bergamot | 📋 | ✍ | ⛔ | | 35807891 | Involvement of the Intestinal Microbiota in the Appearance of Multiple Sclerosis: Aloe vera and Citrus bergamia as Potential Candidates for Intestinal Health |
| Blackberry | 📋 | | ⛔ | | 38430352 | Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling |
| Calcium | 📋 | ✍ | ⛔ | | 38433741 | Association of Calcium and Vitamin D Supplements with Fractures in Persons with a Traumatic SCI |
| Cryptotanshinone | 📋 | | | | 38071213 | Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 32439412 | GAMMA-LINOLENIC ACID ALTERS MIGRATION, PROLIFERATION AND APOPTOSIS IN HUMAN AND RAT GLIOBLASTOMA CELLS |
| Lavender | 📋 | ✍ | ⛔ | | 38089644 | Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia |
| Liquiritin | 📋 | | | | 38074876 | Antidepressant effect of licorice total flavonoids and liquiritin: A review |
| Nootkatone | 📋 | | | | 38001852 | Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson's Disease Mouse Model |
| Phytoestrogens | 📋 | | ⛔ | | 37673213 | Diet-microbiome-immune interplay in multiple sclerosis: Understanding the impact of phytoestrogen metabolizing gut bacteria |
| Roselle | 📋 | ✍ | ⛔ | | 38193451 | An extract of Hibiscus sabdariffa improves short-term memory in rats with experimental diabetic hyperglycemia |
| Sage | 📋 | ✍ | ⛔ | | 35873824 | Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender |
| SAMe | 📋 | ✍ | ⛔ | | 38675528 | Antitumoral Activity of the Universal Methyl Donor S-Adenosylmethionine in Glioblastoma Cells |
| Theaflavins | 📋 | ✍ | | | 37324903 | Isolation and antioxidant characterization of theaflavin for neuroprotective effect in mice model |
| Trans-Resveratrol | 📋 | | | | 35799401 | Neuroprotection by Trans-Resveratrol in Rats With Intracerebral Hemorrhage: Insights into the Role of Adenosine A1 Receptors |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 34564384 | Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson's Disease Dementia |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 38661076 | A preclinical study to determine the anti-epileptic effect of biotin on maximal electroshock (MES) and pentylenetetrazole (PTZ) models in albino rats |
| Black Tea | 📋 | ✍ | ⛔ | | 37483967 | Tea intake or consumption and the risk of dementia: a meta-analysis of prospective cohort studies |
| Boric Acid | 📋 | ✍ | ⛔ | | 37906374 | Boric acid Increases Susceptibility to Chemotherapy by Targeting the Ferritinophagy Signaling Pathway in TMZ Resistant Glioblastoma Cells |
| Chamomile | 📋 | ✍ | ⛔ | | 36302045 | Ameliorative effects of half-dose saffron and chamomile combination on Psycho-endocrinological changes in a diabetic murine model |
| Coconut | 📋 | | ⛔ | | 31350628 | Phenolic rich Cocos nucifera inflorescence extract ameliorates inflammatory responses in LPS-stimulated RAW264.7 macrophages and toxin-induced murine models |
| D-Limonene | 📋 | ✍ | ⛔ | | 36982297 | Limonene, a Monoterpene, Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Modulating Neuroinflammation, Hippo Signaling and Apoptosis in Rats |
| Dihydroartemisinin | 📋 | | | | 38552734 | Dihydroartemisinin protects mice from CUMS-induced depression-like behaviors and regulates gut microbes |
| Fermented Foods | 📋 | | ⛔ | | 38280441 | Probiotic, prebiotic, synbiotic and fermented food supplementation in psychiatric disorders: A systematic review of clinical trials |
| Fiber | 📋 | ✍ | ⛔ | | 38287064 | Associations of cereal fiber intake with rheumatoid arthritis mediated by dietary inflammatory index: insights from NHANES 2011-2020 |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 38623977 | Exploring the Constituents and Mechanisms of Polygonum multiflorum Thunb. in Mitigating Ischemic Stroke: A Network Pharmacology and Molecular Docking Study |
| GABA | 📋 | ✍ | ⛔ | | 38584977 | GABA Administration Ameliorates the Toxicity of Doxorubicin on CSF and the Brain of Albino Rats |
| Galangal | 📋 | ✍ | ⛔ | | 36306920 | Combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus Ameliorates Aluminum-induced Alzheimer's Disease via reducing BACE1 Expression |
| Ginkgetin | 📋 | | | | 36836918 | Neuroprotective Potential of Biflavone Ginkgetin: A Review |
| Hypericin | 📋 | | | | 37734259 | Novel antidepressant mechanism of hypericin: Role of connexin 43-based gap junctions |
| Lotus | 📋 | | ⛔ | | 37346401 | Diospyros lotus leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 37730471 | Randomized Trial Examining Efficacy of Mentha piperita in Reducing Chronic Headache Discomfort in Youth |
| Persimmon | 📋 | | ⛔ | | 35668445 | Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin reuptake in mice |
| Plum | 📋 | | ⛔ | | 37783584 | Plum-blossom needle therapy for Tourette syndrome: A case report |
| Procyanidins | 📋 | | ⛔ | | 35624958 | Grape-Seed-Derived Procyanidin Attenuates Chemotherapy-Induced Cognitive Impairment by Suppressing MMP-9 Activity and Related Blood-Brain-Barrier Damage |
| Soy | 📋 | ✍ | ⛔ | | 37818605 | Effect of dietary supplementation with multinutrient soy flour on body composition and cognitive function in elderly individuals at the risk of low protein: a randomized, double-blind, placebo-controlled study |
| Spermidine | 📋 | | | | 38401586 | Synergistic effect of spermidine and ciprofloxacin against Alzheimer's disease in male rat via ferroptosis modulation |
| UDCA | 📋 | ✍ | ⛔ | | 38313166 | Evaluating the effect of ursodeoxycholic acid (UDCA) in comparison with dexamethasone and diclofenac in a rat model of rheumatoid arthritis |
| Alpha GPC | 📋 | ✍ | ⛔ | | 38595916 | Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease |
| Anise | 📋 | ✍ | ⛔ | | 37755735 | Mechanistic Assessment of Anise Seeds and Clove Buds against the Neurotoxicity Caused by Metronidazole in Rats: Possible Role of Antioxidants, Neurotransmitters, and Cytokines |
| Astragalin | 📋 | | | | 36681681 | Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice |
| Atractylodes | 📋 | ✍ | ⛔ | | 38178130 | Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke |
| Cherry | 📋 | | ⛔ | | 36181653 | Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop |
| Clove | 📋 | | ⛔ | | 37851769 | Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 38218550 | Dietary conjugated linoleic acid downregulates the AlCl3-induced hyperactivation of compensatory and maladaptive signalling in the mouse brain cortex |
| Copper | 📋 | ✍ | ⛔ | | 37875826 | Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES) |
| Diosmetin | 📋 | | | | 38460078 | Diosmetin Ameliorates HFD-induced Cognitive Impairments via Inhibiting Metabolic Disorders, Mitochondrial Dysfunction and Neuroinflammation in Male SD Rats |
| Eucommia | 📋 | ✍ | ⛔ | | 37123081 | Iridoid from Eucommia ulmoides Oliv. Exerts Antiarthritis Effects by Inhibiting the JAK2/STAT3 Signaling Pathway In Vivo and In Vitro |
| Fruits | 📋 | | | | 38347678 | Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study |
| Horny Goat Weed | 📋 | ✍ | ⛔ | | 37237865 | Epimedium Aqueous Extract Ameliorates Cerebral Ischemia/Reperfusion Injury through Inhibiting ROS/NLRP3-Mediated Pyroptosis |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 38403321 | [UPLC-Q-TOF-MS-based metabolomics reveals mechanism of Morinda officinalis iridoid glycosides in treating rheumatoid arthritis and bone loss] |
| Liquiritigenin | 📋 | | | | 37005251 | Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 35706530 | Modified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-ĸB Signaling Pathway in Microglia |
| Patchouli | 📋 | ✍ | ⛔ | | 38419848 | Pogostemon cablin essential oil affects anxiety- and depressive-like behaviors and the gut microbiota in chronic unpredictable mild stress model rats |
| Perilla | 📋 | ✍ | | | 37355083 | Antidepressant effect of Perilla frutescens essential oil through monoamine neurotransmitters and BDNF/TrkB signal pathway |
| Syringic Acid | 📋 | | | | 38430353 | The Protective Effects of Syringic Acid on Bisphenol A-Induced Neurotoxicity Possibly Through AMPK/PGC-1α/Fndc5 and CREB/BDNF Signaling Pathways |
| Apple | 📋 | | ⛔ | | 34222062 | Effect of apple peel extract on diabetes-induced peripheral neuropathy and wound injury |
| Balloon Flower | 📋 | ✍ | ⛔ | | 38491972 | Platycodin D Ameliorates Cognitive Impairment in Type 2 Diabetes Mellitus Mice via Regulating PI3K/Akt/GSK3β Signaling Pathway |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 38142848 | Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice |
| Betulinic Acid | 📋 | | | | 38396785 | Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives |
| Bitter Melon | 📋 | ✍ | ⛔ | | 38682220 | Pharmacotherapeutic Potential of Bitter Gourd (Momordica charantia) in Age-related Neurological Diseases |
| Blackcurrant | 📋 | ✍ | ⛔ | | 37110805 | The Flavonoid Rich Black Currant ( Ribes nigrum) Ethanolic Gemmotherapy Extract Elicits Neuroprotective Effect by Preventing Microglial Body Swelling in Hippocampus and Reduces Serum TNF-α Level: Pilot Study |
| Cat's Claw | 📋 | ✍ | ⛔ | | 38310572 | Comprehensive In Silico Analysis of Uncaria Tomentosa Extract: Chemical Profiling, Antioxidant Assessment, and CLASP Protein Interaction for Drug Design in Neurodegenerative Diseases |
| Citral | 📋 | | | | 37244090 | Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats |
| Cranberry | 📋 | ✍ | ⛔ | | 35662954 | Chronic Consumption of Cranberries ( Vaccinium macrocarpon) for 12 Weeks Improves Episodic Memory and Regional Brain Perfusion in Healthy Older Adults: A Randomised, Placebo-Controlled, Parallel-Groups Feasibility Study |
| Ginger Essential Oil | 📋 | ✍ | | | 38106635 | The preventive effect of Zingiber officinale essential oil on demyelination of corpus callosum in a cuprizone rat model of multiple sclerosis |
| Hemp Oil | 📋 | ✍ | ⛔ | | 33722712 | Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain |
| Kudzu Root | 📋 | ✍ | ⛔ | | 36232220 | Inhibition of LPS-Induced Microglial Activation by the Ethyl Acetate Extract of Pueraria mirifica |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 35747354 | Protective effects of Thai Mucuna pruriens (L.) DC. var. pruriens seeds on sexual behaviors and essential reproductive markers in chronic unpredictable mild stress mice |
| Nutmeg | 📋 | ✍ | ⛔ | | 35662922 | Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease |
| Nuts | 📋 | | ⛔ | | 37542950 | Nut consumption is associated with a lower risk of depression in adults: A prospective analysis with data from the UK Biobank cohort |
| Oleanolic Acid | 📋 | | | | 37541369 | Effects of oleanolic acid and ursolic acid on depression-like behaviors induced by maternal separation in mice |
| Phloretin | 📋 | | | | 36793870 | Phloretin decreases microglia-mediated synaptic engulfment to prevent chronic mild stress-induced depression-like behaviors in the mPFC |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 36779860 | Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 36290760 | Soy Isoflavones Protect Neuronal PC12 Cells against Hypoxic Damage through Nrf2 Activation and Suppression of p38 MAPK and AKT-mTOR Pathways |
| Tea Polyphenols | 📋 | | | | 38286317 | Targeting ERS-mitophagy in hippocampal neurons to explore the improvement of memory by tea polyphenols in aged type 2 diabetic rats |
| Anethole | 📋 | | | | 37987213 | Anethole mitigates H2 O2 -induced inflammation in HIG-82 synoviocytes by suppressing the aquaporin 1 expression and activating the protein kinase A pathway |
| Asparagus | 📋 | | ⛔ | | 37899966 | A network pharmacology approach to explore pharmacological mechanisms of Asparagus racemosus for ameliorative effect in epilepsy and comorbid progressive memory dysfunction |
| Barberry | 📋 | ✍ | ⛔ | | 36910359 | Berberis lyceum root bark extract attenuates anticancer drugs induced neurotoxicity and cardiotoxicity in rats |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 32155616 | The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study |
| BCAA | 📋 | ✍ | ⛔ | | 36060454 | Branched-Chain Amino Acids Are Neuroprotective Against Traumatic Brain Injury and Enhance Rate of Recovery: Prophylactic Role for Contact Sports and Emergent Use |
| Beta-Cryptoxanthin | 📋 | | | | 37378145 | Diet as a Risk Factor for Rheumatoid Arthritis |
| Bilberry | 📋 | ✍ | ⛔ | | 36414183 | Neuroprotective effects of Vaccinium myrtillus on damage-related brain injury |
| Cannabidiol Oil | 📋 | ✍ | ⛔ | | 33998856 | An Open Retrospective Study of a Standardized Cannabidiol Based-Oil in Treatment-Resistant Epilepsy |
| Chicoric Acid | 📋 | | | | 38542381 | Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models |
| Diallyl Disulfide | 📋 | | | | 37844463 | Diallyl disulfide attenuates pyroptosis via NLRP3/Caspase-1/IL-1β signaling pathway to exert a protective effect on hypoxic-ischemic brain damage in neonatal rats |
| Eleuthero | 📋 | ✍ | ⛔ | | 38545117 | Acanthopanax senticosus improves cognitive impairment in Alzheimer's disease by promoting the phosphorylation of the MAPK signaling pathway |
| Equol | 📋 | ✍ | ⛔ | | 34157864 | Roles of Phytoestrogen in the Pathophysiology of Intracranial Aneurysm |
| Fig | 📋 | | ⛔ | | 34451731 | Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors |
| Frankincense Essential Oil | 📋 | | ⛔ | | 37783585 | The effect of back massage with frankincense and myrrh oil before the cardiac electrophysiological procedure on back pain intensity and comfort: A single-blind randomized controlled trial |
| Giloy | 📋 | ✍ | ⛔ | | 38176666 | Protective effects of Tinospora cordifolia miers extract against hepatic and neurobehavioral deficits in thioacetamide-induced hepatic encephalopathy in rats via modulating hyperammonemia and glial cell activation |
| Isoquercitrin | 📋 | | | | 38065271 | Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway |
| Krill Oil | 📋 | ✍ | ⛔ | | 37564375 | Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38489176 | Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease |
| L-Lysine | 📋 | ✍ | ⛔ | | 35696944 | Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 35892594 | Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy |
| Long Pepper | 📋 | | ⛔ | | 37821784 | The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction |
| Neem | 📋 | ✍ | | | 36382046 | Effects of Azadirachta indica on neuropathic pain induced by chronic constriction injury to sciatic nerve of Wistar rat |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 35583855 | Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 38705428 | LC-qTOF-MS/MS phytochemical profiling of Tabebuia impetiginosa (Mart. Ex DC.) Standl. leaf and assessment of its neuroprotective potential in rats |
| Piperlongumine | 📋 | | | | 38334976 | Protective effects of piperlongumine against adjuvant-induced arthritis in rats through modulating OPG/RANKL/NF-κB signaling pathway |
| Red Yeast Rice | 📋 | ✍ | ⛔ | | 36917811 | Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways |
| Shilajit | 📋 | ✍ | ⛔ | | 38073457 | Histopathological and immunohistochemical investigation of the effect of Shilajit in rats with experimental spinal cord injury |
| Sirtuin Activators | 📋 | | | | 36306110 | SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders |
| Spices | 📋 | | | | 36438833 | From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders |
| Thyme Essential Oil | 📋 | | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Vitamin K2 mk-4 | 📋 | ✍ | | | 38727984 | Menaquinone-4 Alleviates Neurological Deficits Associated with Intracerebral Hemorrhage by Preserving Corticospinal Tract in Mice |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 37477796 | Vitamin K2 protects against aluminium chloride-mediated neurodegeneration |
| Zingerone | 📋 | | | | 38419893 | Zingerone attenuates sciatic nerve damage caused by sodium arsenite by inhibiting NF-κB, caspase-3, and ATF-6/CHOP pathways and activating the Akt2/FOXO1 pathway |
| Almond | 📋 | | ⛔ | | 34832965 | The Inhibitory Effects of Terminalia catappa L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 34323669 | Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD |
| Asafoetida | 📋 | ✍ | ⛔ | | 36857494 | Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease |
| Bay Leaf | 📋 | | ⛔ | | 36978994 | Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol |
| Beets | 📋 | ✍ | ⛔ | | 33961320 | Anti-hypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain |
| Berries | 📋 | | | | 29401686 | Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects |
| Cardamom | 📋 | ✍ | ⛔ | | 36781058 | Cardamom oil ameliorates behavioral and neuropathological disorders in a rat model of depression induced by reserpine |
| Cheese | 📋 | | ⛔ | | 38694223 | Association between cheese and fish consumption and the occurrence of depression based on European population: mediating role of metabolites |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 36567616 | Neuroprotective effects of Chrysanthemum morifolium on cerebral ischemia- reperfusion injury contributes to the oxidative stress suppression and related Keap1/Nrf2 pathway |
| Cinnamic Acid | 📋 | | | | 35799788 | A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis |
| D-Mannose | 📋 | ✍ | ⛔ | | 35490896 | Mannose inhibits proliferation and promotes apoptosis to enhance sensitivity of glioma cells to temozolomide through Wnt/β-catenin signaling pathway |
| Date | 📋 | | ⛔ | | 36840284 | Neuroprotective Effect of Methanolic Ajwa Seed Extract on Lipopolysaccharide-Induced Memory Dysfunction and Neuroinflammation: In Vivo, Molecular Docking and Dynamics Studies |
| Diallyl Trisulfide | 📋 | | | | 37932742 | Diallyl trisulfide improves spinal cord ischemia-reperfusion injury damage by activating AMPK to stabilize mitochondrial function |
| Eucalyptol | 📋 | | | | 38649658 | Molecular insights of Eucalyptol (1,8-Cineole) as an anti-arthritic agent: in vivo and in silico analysis of IL-17, IL-10, NF-κB, 5-LOX and COX-2 |
| Feverfew | 📋 | ✍ | ⛔ | | 38204302 | Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 37960203 | Flaxseed Oil ( Linum usitatissimum) Prevents Cognitive and Motor Damage in Rats with Hyperammonemia |
| Genipin | 📋 | | | | 37865990 | Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease |
| HMB | 📋 | ✍ | ⛔ | | 38419348 | Muscle-building supplement β-hydroxy β-methylbutyrate stimulates the maturation of oligodendroglial progenitor cells to oligodendrocytes |
| Isoflavones | 📋 | ✍ | ⛔ | | 35740885 | Dietary Phytoestrogen Intake and Cognitive Status in Southern Italian Older Adults |
| Isorhamnetin | 📋 | | | | 38212502 | Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway |
| Jasmine | 📋 | | ⛔ | | 35010973 | Jasmine Tea Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior in Rats via the Gut-Brain Axis |
| Jujube | 📋 | | ⛔ | | 38562322 | Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models |
| Kiwifruit | 📋 | ✍ | ⛔ | | 34831142 | Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis |
| Knotweed | 📋 | ✍ | ⛔ | | 37876500 | Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway |
| Lauric Acid | 📋 | ✍ | | | 37572940 | Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke |
| Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 38030022 | Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models |
| Lychee | 📋 | | ⛔ | | 33984432 | Pronounced anti-neuroinflammatory jasmonates and terpenes isolated from lychee seeds |
| Maca Root | 📋 | ✍ | ⛔ | | 35190953 | Macamide B Pretreatment Attenuates Neonatal Hypoxic-Ischemic Brain Damage of Mice Induced Apoptosis and Regulates Autophagy via the PI3K/AKT Signaling Pathway |
| Maitake Mushrooms | 📋 | | ⛔ | | 34071571 | Anti-Inflammatory and Immunomodulatory Effects of the Grifola frondosa Natural Compound o-Orsellinaldehyde on LPS-Challenged Murine Primary Glial Cells. Roles of NF-κβ and MAPK |
| Marjoram | 📋 | | ⛔ | | 38313221 | Origanum majorana L. polyphenols: in vivo antiepileptic effect, in silico evaluation of their bioavailability, and interaction with the NMDA receptor |
| Nattokinase | 📋 | ✍ | ⛔ | | 37466380 | Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin |
| Neohesperidin | 📋 | | | | 38226659 | Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice |
| Nimbolide | 📋 | | | | 38036978 | In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 37971997 | Association between the intake of dietary n3 and n6 fatty acids and stroke in US adults: A cross-sectional study of NHANES 2007-2018 |
| Orange | 📋 | | ⛔ | | 36678510 | Characterization of Orange Peel Extract and Its Potential Protective Effect against Aluminum Chloride-Induced Alzheimer's Disease |
| Pelargonidin | 📋 | | | | 36226369 | Pelargonidin inhibits vascularization and metastasis of brain gliomas by blocking the PI3K/AKT/mTOR pathway |
| Phosphatidylserine | 📋 | ✍ | ⛔ | | 35992593 | Phosphatidylserine, inflammation, and central nervous system diseases |
| Pomegranate Seed extract | 📋 | | ⛔ | | 35348947 | Amelioration of oxidative stress, cholinergic dysfunction, and neuroinflammation in scopolamine-induced amnesic rats fed with pomegranate seed |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 37400700 | Cucurbita pepo seeds improve peripheral neuropathy in diabetic rats by modulating the inflammation and oxidative stress in rats |
| Rose Essential Oil | 📋 | | | | 38688895 | A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats |
| Safflower | 📋 | ✍ | ⛔ | | 36768450 | Combination of Radix Astragali and Safflower Promotes Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2 |
| Sesame Oil | 📋 | | ⛔ | | 38548024 | The Protective Role of Sesame Oil against Parkinson's-Like Disease Induced by Manganese in Rats |
| Vegetables | 📋 | | | | 37405378 | Increased Intake of Vegetables and Fruits Improves Cognitive Function among Chinese Oldest Old: 10-Year Follow-Up Study |
| Aloin | 📋 | | | | 35421539 | Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin |
| Anthocyanidins | 📋 | | | | 37474898 | Association between dietary anthocyanidins intake and depression among US adults: a cross-sectional study (NHANES, 2007-2010 and 2017-2018) |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 36904193 | Association between Arachidonic Acid and the Risk of Schizophrenia: A Cross-National Study and Mendelian Randomization Analysis |
| Beta-Lapachone | 📋 | | | | 30739428 | Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways |
| Boron | 📋 | ✍ | ⛔ | | 36006107 | Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study |
| Burdock | 📋 | | ⛔ | | 34439529 | 1,3-Dicaffeoylquinic Acid as an Active Compound of Arctium lappa Root Extract Ameliorates Depressive-Like Behavior by Regulating Hippocampal Nitric Oxide Synthesis in Ovariectomized Mice |
| Casein Protein | 📋 | ✍ | ⛔ | | 36245498 | The anti-anxiety/depression effect of a combined complex of casein hydrolysate and γ-aminobutyric acid on C57BL/6 mice |
| Cashew | 📋 | | ⛔ | | 38002521 | Cashew ( Anacardium occidentale) Extract: Possible Effects on Hypothalamic-Pituitary-Adrenal (HPA) Axis in Modulating Chronic Stress |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 38053824 | Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system |
| Chlorella | 📋 | ✍ | ⛔ | | 37144207 | Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 32785956 | Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity |
| Cornus | 📋 | | | | 37393274 | Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis |
| Costus | 📋 | ✍ | ⛔ | | 36451529 | Saussurea involucrata oral liquid regulates gut microbiota and serum metabolism during alleviation of collagen-induced arthritis in rats |
| Eclipta Alba | 📋 | ✍ | | | 38562322 | Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models |
| Essential Amino Acids | 📋 | ✍ | ⛔ | | 34836128 | Deficiency in the Essential Amino Acids l-Isoleucine, l-Leucine and l-Histidine and Clinical Measures as Predictors of Moderate Depression in Elderly Women: A Discriminant Analysis Study |
| Essential Fatty Acids | 📋 | ✍ | | | 33337250 | Nutritional interventions for the prevention of cognitive impairment and dementia in developing economies in East-Asia: a systematic review and meta-analysis |
| Forskolin | 📋 | ✍ | ⛔ | | 36614135 | Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats |
| Glabridin | 📋 | | | | 38372849 | Glabridin reduces neuroinflammation by modulating inflammatory signals in LPS-induced in vitro and in vivo models |
| Glutathione | 📋 | ✍ | ⛔ | | 38474196 | The Role of Glutathione in the Management of Cell-Mediated Immune Responses in Individuals with HIV |
| Glycine | 📋 | ✍ | ⛔ | | 37975960 | The Effect of Glycine and N-Acetylcysteine on Oxidative Stress in the Spinal Cord and Skeletal Muscle After Spinal Cord Injury |
| Glycyrrhetinic Acid | 📋 | | | | 38092318 | Exploring the efficacy and mechanism of Glycyrrhizae Radix et Rhizoma in improving collagen-induced arthritis in mice |
| Inulin | 📋 | ✍ | ⛔ | | 37625336 | Inulin alleviates neuroinflammation and oxidative stress induced by perinatal 2-ethylhexyl diphenyl phosphate (EHDPHP) exposure in female mice and offspring |
| L-Alanine | 📋 | ✍ | ⛔ | | 33626855 | Extremely Low Serum Alanine Transaminase Level Is Associated with All-Cause Mortality in the Elderly after Intracranial Hemorrhage |
| L-Leucine | 📋 | ✍ | ⛔ | | 38382647 | Vcp overexpression and leucine supplementation extend lifespan and ameliorate neuromuscular junction phenotypes of a SOD1G93A-ALS mouse model |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 35583855 | Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils |
| Lupeol | 📋 | | | | 37447385 | A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer's Disease |
| Madecassoside | 📋 | | | | 38181970 | Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration |
| Marjoram Essential Oil | 📋 | | ⛔ | | 38045619 | Inhalation of Origanum majorana L. essential oil while working reduces perceived stress and anxiety levels of nurses in a COVID-19 intensive care unit: a randomized controlled trial |
| Minerals | 📋 | | | | 38244989 | Effect of multivitamin-mineral supplementation versus placebo on cognitive function: Results from the clinic sub-cohort of the COSMOS randomized clinical trial and meta-analysis of three cognitive studies within COSMOS |
| MSM | 📋 | ✍ | ⛔ | | 35203043 | Methylsulfonylmethane protects against ethanol-induced brain injury in mice through the inhibition of oxidative stress, proinflammatory mediators and apoptotic cell death |
| Onion | 📋 | ✍ | ⛔ | | 38722415 | Towards a natural treatment for mania: red onion husk extract modulates neuronal resilience, redox signalling, and glial activation |
| Oolong Tea | 📋 | | ⛔ | | 35629970 | Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35354677 | Antinociceptive, anti-inflammatory, and cytotoxic properties of Origanum vulgare essential oil, rich with β-caryophyllene and β-caryophyllene oxide |
| Potassium | 📋 | ✍ | ⛔ | | 37875826 | Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES) |
| Quercitrin | 📋 | | | | 36292931 | The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway |
| Raspberry | 📋 | ✍ | ⛔ | | 35016667 | Effectiveness of maturity of Rubus occidentalis on hyperalgesia induced by acidic saline injection in rats |
| Seafood | 📋 | | | | 38706279 | Fish and Shellfish Consumption, Cognitive Health and Mortality from Alzheimer's Disease among US Adults Aged 60 and Older |
| Shensong Yangxin | 📋 | ✍ | | | 32237459 | [Network Meta-analysis of randomized controlled trials of Chinese patent medicine for bradyarrhythmia] |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 31772594 | Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections |
| Thyme | 📋 | ✍ | ⛔ | | 38039009 | Effects of orally administered Thymus vulgaris leaves on memory, anxiety, depression, and sleep quality in university students: a randomized controlled trial |
| Toothache Plant | 📋 | | | | 35733629 | Promising Health Benefits of Adjuvant Acmella and Zingiber Extracts Combined with Coenzyme Q10 Phytosomes, Supplementation in Chronic Pain Treated with Medical Cannabis: A Prospective and Open-Label Clinical Study |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 36289766 | Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice |
| Whey Protein | 📋 | ✍ | ⛔ | | 37414601 | Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway |
| Wine | 📋 | | ⛔ | | 35943074 | Long term effects of red wine consumption in brain: an MRI, fMRI and neuropsychological evaluation study |
| Apple Polyphenols | 📋 | | ⛔ | | 38406886 | Apple polyphenol extract ameliorates sugary-diet-induced depression-like behaviors in male C57BL/6 mice by inhibiting the inflammation of the gut-brain axis |
| Avocado | 📋 | ✍ | ⛔ | | 34722611 | US Older Adults That Consume Avocado or Guacamole Have Better Cognition Than Non-consumers: National Health and Nutrition Examination Survey 2011-2014 |
| Beta-Alanine | 📋 | ✍ | ⛔ | | 36839281 | Role of β-Alanine Supplementation on Cognitive Function, Mood, and Physical Function in Older Adults; Double-Blind Randomized Controlled Study |
| Bitter Orange | 📋 | ✍ | ⛔ | | 38078339 | Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats |
| Black Pepper Essential Oil | 📋 | | ⛔ | | 33997409 | Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum Linn. (Black pepper) in mice: involvement of serotonergic but not GABAergic transmission system |
| Cardamonin | 📋 | | | | 37268255 | The natural chalcone cardamonin selectively induces apoptosis in human neuroblastoma cells |
| Celery | 📋 | | ⛔ | | 37570794 | Neurological Applications of Celery ( Apium graveolens): A Scoping Review |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 34069679 | Evaluation of Motor Coordination and Antidepressant Activities of Cinnamomum osmophloeum ct. Linalool Leaf Oil in Rodent Model |
| Citrus Fruits | 📋 | | ⛔ | | 35565814 | A Narrative Review of the Effects of Citrus Peels and Extracts on Human Brain Health and Metabolism |
| Collagen | 📋 | ✍ | | | 37551682 | Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults |
| Corn Silk | 📋 | ✍ | ⛔ | | 37563784 | Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation |
| DIM | 📋 | ✍ | ⛔ | | 35461819 | 3,3'-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice |
| Docosapentaenoic Acid | 📋 | ✍ | | | 35166302 | Twelve Weeks of Additional Fish Intake Improves the Cognition of Cognitively Intact, Resource-Limited Elderly People: A Randomized Control Trial |
| Eucalyptus | 📋 | ✍ | ⛔ | | 36060153 | The effect of eucalyptus inhalation on pain and the quality of life in rheumatoid arthritis |
| Fennel | 📋 | ✍ | ⛔ | | 33598155 | Methanolic extract of Fennel ( Foeniculum vulgare) escalates functional restoration following a compression injury to the sciatic nerve in a mouse model |
| Geranium | 📋 | | | | 37819493 | Therapeutic Effects of Geranium Oil in MPTP-Induced Parkinsonian Mouse Model |
| Ginkgolic Acid | 📋 | | | | 36396110 | CCL2-targeted ginkgolic acid exerts anti-glioblastoma effects by inhibiting the JAK3-STAT1/PI3K-AKT signaling pathway |
| Graviola | 📋 | ✍ | ⛔ | | 35485570 | Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis |
| Hazelnut | 📋 | | ⛔ | | 38151890 | Does hazelnut consumption affect brain health and function against neurodegenerative diseases? |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 37765216 | Hyaluronic Acid in Rheumatology |
| Iron | 📋 | ✍ | ⛔ | | 25837213 | Dietary intake of minerals in relation to depressive symptoms in Japanese employees: the Furukawa Nutrition and Health Study |
| L-Methionine | 📋 | ✍ | ⛔ | | 34573099 | L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson's Disease |
| Lemon Verbena | 📋 | | ⛔ | | 35011093 | Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract |
| Lemongrass Essential Oil | 📋 | ✍ | ⛔ | | 33910044 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish |
| Limonin | 📋 | | | | 37536186 | Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats |
| Lingonberry | 📋 | | ⛔ | | 30353787 | Lingonberries and their two separated fractions differently alter the gut microbiota, improve metabolic functions, reduce gut inflammatory properties, and improve brain function in ApoE-/- mice fed high-fat diet |
| Loquat | 📋 | ✍ | ⛔ | | 37513484 | Dried Loquat Fruit Extract Containing Chlorogenic Acid Prevents Depressive-like Behaviors Induced by Repeated Corticosteroid Injections in Mice |
| Malvidin | 📋 | | | | 36699054 | Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice |
| Mango Leaf | 📋 | | ⛔ | | 29557530 | Neuroprotective efficiency of Mangifera indica leaves extract on cadmium-induced cortical damage in rats |
| Marigold | 📋 | ✍ | ⛔ | | 38268908 | Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease |
| Morusin | 📋 | | | | 26829656 | Morusin Induces TRAIL Sensitization by Regulating EGFR and DR5 in Human Glioblastoma Cells |
| Nuciferine | 📋 | | | | 38658097 | Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance |
| Oats | 📋 | | ⛔ | | 34684684 | Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice |
| Oleic Acid | 📋 | | ⛔ | | 34040528 | Combined Oral and Topical Application of Pumpkin ( Cucurbita pepo L.) Alleviates Contact Dermatitis Associated With Depression Through Downregulation Pro-Inflammatory Cytokines |
| Papaya | 📋 | ✍ | ⛔ | | 36934258 | Antiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection |
| Peanut | 📋 | | ⛔ | | 35418581 | Peanut (Arachis hypogaea) sprout prevents high-fat diet-induced cognitive impairment by improving mitochondrial function |
| Pear | 📋 | | ⛔ | | 34602398 | Determination of anxiolytic and antidepressant like activity of hydro alcoholic fruit extract of Pyrus communis (L.) and its impact on the memory after chronic dosing in animal models |
| Pectin | 📋 | ✍ | ⛔ | | 33618606 | Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain |
| Pineapple | 📋 | ✍ | ⛔ | | 34461191 | Ananas comosus (L) Merrill (pineapple) fruit peel extract demonstrates antimalarial, anti-nociceptive and anti-inflammatory activities in experimental models |
| Pistachio | 📋 | ✍ | ⛔ | | 35075081 | Chronically Pre-treatment of Pistachio Alters the Morphology of CA1 Hippocampus Neurons Following Transient Focal Cerebral Ischemia in Male Wistar Rats |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 31987026 | An Evaluation of the Effects of Pyridoxal Phosphate in Chlorpromazineinduced Parkinsonism using Mice |
| Quinoa | 📋 | | ⛔ | | 38337665 | The Neuroprotective Role of Quinoa ( Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats |
| Rehmannia | 📋 | ✍ | ⛔ | | 35784741 | Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on Transgenic Caenorhabditis elegans Models for Alzheimer's Disease |
| Rose | 📋 | | | | 38089182 | Neuroprotective Effects of Rosa damascena Extract against Aluminum Chloride-Induced Brain Damage in Rat Offspring |
| Rosehip | 📋 | ✍ | ⛔ | | 37088237 | Rosa canina L. improves learning and memory-associated cognitive impairment by regulating glucose levels and reducing hippocampal insulin resistance in high-fat diet/streptozotocin-induced diabetic rats |
| Sage Essential Oil | 📋 | | ⛔ | | 31618702 | HPTLC based approach for bioassay-guided evaluation of antidiabetic and neuroprotective effects of eight essential oils of the Lamiaceae family plants |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 26788112 | Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell |
| Seaweeds | 📋 | | ⛔ | | 37447330 | Activation of Liver X Receptors and Peroxisome Proliferator-Activated Receptors by Lipid Extracts of Brown Seaweeds: A Potential Application in Alzheimer's Disease? |
| Serrapeptase | 📋 | ✍ | ⛔ | | 35694981 | The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach |
| Theobromine | 📋 | ✍ | ⛔ | | 37121724 | Comparing Effects of Caffeine and Theobromine on Adrenal Hypertrophy and Social Behavior in Psychosocial Stressed Mice |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 30574050 | Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 36826058 | Neurobiology and Applications of Inositol in Psychiatry: A Narrative Review |
| Vitex | 📋 | ✍ | ⛔ | | 36121091 | Potential Phytoconstituents of Genus Vitex for the Management of Rheumatoid Arthritis: A Review |
| Yiang Yiang Essential Oil | 📋 | | ⛔ | | 35551977 | Ylang-ylang (Cananga odorata (Lam.) Hook. f. & Thomson) essential oil reduced neuropathic-pain and associated anxiety symptoms in mice |
| Amygdalin | 📋 | ✍ | ⛔ | | 37894605 | TMT-Based Proteomics Reveal the Mechanism of Action of Amygdalin against Rheumatoid Arthritis in a Rat Model through Regulation of Complement and Coagulation Cascades |
| Apricot | 📋 | | ⛔ | | 36212969 | Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model |
| Arctiin | 📋 | | | | 32609480 | Antidepressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- and TNF-α/TNFR1-Mediated NF-κB Activation |
| Argan Oil | 📋 | ✍ | ⛔ | | 29065513 | Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N |
| Arnica | 📋 | ✍ | ⛔ | | 34677487 | Clinical Trials, Potential Mechanisms, and Adverse Effects of Arnica as an Adjunct Medication for Pain Management |
| Artichoke | 📋 | ✍ | ⛔ | | 36556233 | Artichoke (Cynara Scolymus) Methanolic Leaf Extract Alleviates Diethylnitrosamine-Induced Toxicity in BALB/c Mouse Brain: Involvement of Oxidative Stress and Apoptotically Related Klotho/PPARγ Signaling |
| Avocado Oil | 📋 | | ⛔ | | 33480081 | Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules |
| Barley | 📋 | ✍ | ⛔ | | 36087390 | Effect of aqueous extract of barley and wheat grass in stress induced depression in Swiss mice |
| Bee Pollen | 📋 | ✍ | ⛔ | | 34774703 | Bee pollen increases hippocampal brain-derived neurotrophic factor and suppresses neuroinflammation in adult rats with chronic immobilization stress |
| Bergamottin | 📋 | | | | 33920139 | Bergamottin and 5-Geranyloxy-7-methoxycoumarin Cooperate in the Cytotoxic Effect of Citrus bergamia (Bergamot) Essential Oil in Human Neuroblastoma SH-SY5Y Cell Line |
| Black Ginger | 📋 | ✍ | ⛔ | | 36904098 | Kaempferia parviflora Extracts Protect Neural Stem Cells from Amyloid Peptide-Mediated Inflammation in Co-Culture Model with Microglia |
| Brazil Nut | 📋 | | ⛔ | | 35052615 | Selenomethionine Ameliorates Cognitive Impairment, Decreases Hippocampal Oxidative Stress and Attenuates Dysbiosis in D-Galactose-Treated Mice |
| Broccoli | 📋 | | ⛔ | | 37839110 | The preventive effects of broccoli bioactives against cancer: Evidence from a validated rat glioma model |
| Buckwheat | 📋 | | ⛔ | | 35807886 | Buckwheat Flour and Its Starch Prevent Age-Related Cognitive Decline by Increasing Hippocampal BDNF Production in Senescence-Accelerated Mouse Prone 8 Mice |
| Cabbage | 📋 | | ⛔ | | 37781995 | Red Cabbage Anthocyanins Attenuate Cognitive Impairment By Attenuating Neuroinflammation and Regulating Gut Microbiota in Aging Mice |
| Camphor | 📋 | ✍ | ⛔ | | 36925623 | Camphor Attenuates Hyperalgesia in Neuropathic Pain Models in Mice |
| Castor Oil | 📋 | ✍ | ⛔ | | 34836854 | Antipyretic and antinociceptive potential of Ricinus communis L. and Withania somnifera L. hydroalcoholic extracts in Wistar rats: A comparative study |
| Clove Essential Oil | 📋 | | ⛔ | | 37119836 | Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease |
| Dairy | 📋 | | | | 37492650 | Dairy products intake and the risk of postpartum depression among mothers: A pilot study |
| Fat | 📋 | | | | 36986159 | Dietary Fats and Cognitive Status in Italian Middle-Old Adults |
| Flaxseed | 📋 | ✍ | ⛔ | | 34837524 | The effect of flaxseed with or without anti-inflammatory diet in patients with rheumatoid arthritis, a randomized controlled trial |
| Garlic Oil | 📋 | | ⛔ | | 37435927 | Garlic essential oil ameliorates depression-like behaviors in unpredictable chronic mild stress by modulating the brain NLRP3 inflammasome pathway and influencing the gut barrier and microbiota |
| Geranium Essential Oil | 📋 | | ⛔ | | 31490773 | Oral supplementation with geranium oil or anise oil ameliorates depressed rat-related symptoms through oils antioxidant effects |
| Grape Seed Oil | 📋 | | ⛔ | | 32665902 | Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases |
| Grapefruit Essential Oil | 📋 | ✍ | ⛔ | | 35583855 | Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils |
| Guava | 📋 | | ⛔ | | 36934258 | Antiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection |
| Hops | 📋 | ✍ | ⛔ | | 35498911 | Discovery of 8-prenylnaringenin from hop ( Humulus lupulus L.) as a potent monoacylglycerol lipase inhibitor for treatments of neuroinflammation and Alzheimer's disease |
| Horse Chestnut | 📋 | ✍ | ⛔ | | 32407839 | Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 36982577 | Novel Approach to the Treatment of Neuropathic Pain Using a Combination with Palmitoylethanolamide and Equisetum arvense L. in an In Vitro Study |
| Hyssop | 📋 | ✍ | ⛔ | | 36287300 | Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 35673507 | Protective effects of Labisia pumila against neuropathy in a diabetic rat model |
| L-Citrulline | 📋 | ✍ | ⛔ | | 33940559 | Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease |
| L-Histidine | 📋 | ✍ | ⛔ | | 36164730 | Histidine supplementation can escalate or rescue HARS deficiency in a Charcot Marie Tooth Disease model |
| Lemongrass | 📋 | ✍ | ⛔ | | 33910044 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish |
| Lettuce | 📋 | | ⛔ | | 35392648 | Lettuce as an Effective Remedy in Uremic Pruritus: Review of the Literature Supplemented by an In Silico Study |
| Manganese | 📋 | ✍ | ⛔ | | 35369103 | Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies |
| Mango | 📋 | | ⛔ | | 35344129 | Antidepressant activity of phytochemicals of Mangifera indica seeds assisted by integrated computational analysis |
| Matcha Tea | 📋 | | | | 36771286 | Matcha Tea Powder's Antidepressant-like Effect through the Activation of the Dopaminergic System in Mice Is Dependent on Social Isolation Stress |
| Myrrh Essential Oil | 📋 | | ⛔ | | 37783585 | The effect of back massage with frankincense and myrrh oil before the cardiac electrophysiological procedure on back pain intensity and comfort: A single-blind randomized controlled trial |
| Myrtle | 📋 | ✍ | ⛔ | | 30553998 | Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors |
| Neroli Essential Oil | 📋 | ✍ | ⛔ | | 37469751 | The Effect of Aromatherapy with Citrus aurantium Aroma on Pain after Orthopedic Surgery: A Randomized Clinical Trial |
| Okra | 📋 | | ⛔ | | 38060590 | Protective and therapeutic effects of okra seed in acute nontraumatic brain injury |
| Omega-9 Fatty Acids | 📋 | | | | 34666393 | Selective Toxicity Effect of Fatty Acids Omega-3, 6 and 9 Combination on Glioblastoma Neurons through their Mitochondria |
| Oregano | 📋 | ✍ | ⛔ | | 36284120 | Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy |
| Osmanthus | 📋 | ✍ | ⛔ | | 38544932 | The inhalation effect of Osmanthus fragrans var. Aurantiacus on physiological parameters in chronically stressed rats |
| Pantethine | 📋 | ✍ | ⛔ | | 37194410 | Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species |
| Parsley | 📋 | | ⛔ | | 34173678 | Investigation of possible neuroprotective effects of some plant extracts on brain in bile duct ligated rats |
| Peppermint | 📋 | ✍ | ⛔ | | 38625964 | Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities |
| Phellodendron | 📋 | ✍ | ⛔ | | 18426577 | Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial |
| Phytosterols | 📋 | | | | 38327787 | Cholesterol-metabolism, plant sterols, and long-term cognitive decline in older people - Effects of sex and APOEe4 |
| Pine Nut | 📋 | | ⛔ | | 37821052 | Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease |
| Proanthocyanidins | 📋 | | | | 35185451 | Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model |
| Protein | 📋 | ✍ | ⛔ | | 38674911 | Analysis of the Association between Protein Intake and Disability-Adjusted Life Year Rates for Alzheimer's Disease in Japanese Aged over 60 |
| Psyllium | 📋 | ✍ | ⛔ | | 31103857 | Intake of Psyllium Seed Husk Reduces White Matter Damage in a Rat Model of Chronic Cerebral Hypoperfusion |
| Pumpkin | 📋 | | ⛔ | | 34336111 | L. Cucurbita pepo Alleviates Chronic Unpredictable Mild Stress via Modulation of Apoptosis, Neurogenesis, and Gliosis in Rat Hippocampus |
| Rhubarb | 📋 | | ⛔ | | 38668344 | The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways |
| Rice | 📋 | | ⛔ | | 37375622 | Rice Germ Attenuates Chronic Unpredictable Mild Stress-Induced Muscle Atrophy |
| Rosavin | 📋 | | ⛔ | | 37758932 | Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer's disease activity in Wister rat model |
| Sesame | 📋 | ✍ | ⛔ | | 37539928 | Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 14572878 | Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells |
| Sugarcane | 📋 | | ⛔ | | 35422173 | Flavonoids and fractions from Saccharum officinarum L. juice: antinociceptive agents and molecular docking evaluations with µ-opioid receptor |
| Tamarind | 📋 | | ⛔ | | 36002437 | Tamarindus indica ameliorates behavioral and cytoarchitectural changes in the cerebellar cortex following prenatal aluminum chloride exposure in Wistar rats |
| Tomato | 📋 | | ⛔ | | 38016800 | Tomato and Lemon Extracts Synergistically Improve Cognitive Function by Increasing Brain-derived Neurotrophic Factor Levels in Aged Mice |
| Xylitol | 📋 | ✍ | ⛔ | | 36154609 | Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice |
| Yogurt | 📋 | | ⛔ | | 38306036 | The Relationship Between Fermented Dairy Consumption with Cognitive Function Among Older US Adults: Data from the NHANES 2011-2014 |
| Acemannan | 📋 | | | | 8680886 | Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease |
| Activated Charcoal | 📋 | ✍ | ⛔ | | 38146721 | Effects of Increased Blood Flow Rate and Oral Activated Charcoal on the Severity of Uremic Pruritus: A Randomized Crossover Clinical Trial |
| Alfalfa | 📋 | | ⛔ | | 32113847 | Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model |
| Amino Acids | 📋 | | | | 35471671 | The potential roles of amino acids and their major derivatives in the management of multiple sclerosis |
| Arjuna | 📋 | ✍ | ⛔ | | 26195913 | Evaluation of analgesic activity of Terminalia arjuna (Roxb.) Wight and Arn bark: A tribal claim |
| Ashitaba | 📋 | ✍ | ⛔ | | 37403256 | The neuroprotective effects of Chalcones from Ashitaba on cuprizone-induced demyelination via modulation of brain-derived neurotrophic factor and tumor necrosis factor α |
| Bamboo | 📋 | ✍ | ⛔ | | 38334213 | The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model |
| Bell Pepper | 📋 | | ⛔ | | 34799309 | Analgesic and anti-inflammatory potential of four varieties of bell pepper (Capsicum annum L.) in rodents |
| Bread | 📋 | | | | 38528644 | Sourdough bread as nutritional intervention tool for improvement of cognitive dysfunction in diabetic rats |
| Camellia | 📋 | | ⛔ | | 35204294 | The Antinociceptive Potential of Camellia japonica Leaf Extract, (-)-Epicatechin, and Rutin against Chronic Constriction Injury-Induced Neuropathic Pain in Rats |
| Camphor Essential Oil | 📋 | | ⛔ | | 38621882 | [Essential oil of Cinnamomum camphora mitigates depression-like behavior in mice by regulating Nrf2/HO-1 pathway and inhibiting inflammatory cytokines] |
| Captopril | 📋 | | | | 26398443 | Effects of Curcumin and Captopril on the Functions of Kidney and Nerve in Streptozotocin-Induced Diabetic Rats: Role of Angiotensin Converting Enzyme 1 |
| Caraway | 📋 | | ⛔ | | 32113847 | Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model |
| Carbohydrates | 📋 | | | | 36539697 | Association of low-carbohydrate-diet score and cognitive performance in older adults: National Health and Nutrition Examination Survey (NHANES) |
| Cedarwood Essential Oil | 📋 | ✍ | ⛔ | | 32037737 | Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia |
| Chebulinic Acid | 📋 | | | | 37453379 | Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses |
| Chia Seeds | 📋 | | ⛔ | | 38104182 | Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways |
| Chickpea | 📋 | | ⛔ | | 28552514 | Aluminum-induced Molecular Neurodegeneration: The Protective Role of Genistein and Chickpea Extract |
| Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 32575103 | Effectiveness of Aromatherapy for Relief of Pain, Nausea, and Vomiting after Percutaneous Nephrolithotomy: A Randomized Controlled Trial |
| Cucumber | 📋 | | ⛔ | | 34354417 | Analgesic and anti-inflammatory effects and safety profile of Cucurbita maxima and Cucumis sativus seeds |
| Cumin | 📋 | | ⛔ | | 36601514 | Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats |
| DMAE | 📋 | ✍ | ⛔ | | 112632 | Dimethylaminoethanol (deanol): effect on apomorphine-induced stereotypy and an animal model of tardive dyskinesia |
| Egg | 📋 | | ⛔ | | 36650485 | Egg consumption reduces the risk of depressive symptoms in the elderly: findings from a 6-year cohort study |
| Eucalyptus Essential Oil | 📋 | | ⛔ | | 31091506 | Analgesic effects of eucalyptus essential oil in mice |
| Fir Needle Oil | 📋 | | ⛔ | | 36429972 | Relaxing Effects of Breathing Pseudotsuga menziesii and Lavandula angustifolia Essential Oils on Psychophysiological Status in Older Adults |
| Fish Collagen | 📋 | ✍ | ⛔ | | 35582851 | Structure of type II collagen from sturgeon cartilage and its effect on adjuvant-induced rheumatoid arthritis in rats |
| Fufang Danshen | 📋 | | | | 29770796 | Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease |
| Geraniin | 📋 | | | | 35222793 | Geraniin Protects against Cerebral Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Neuronal Apoptosis via Regulation of the Nrf2/HO-1 Pathway |
| Grapefruit | 📋 | | ⛔ | | 36500599 | Recovery of Naringin-Rich Flavonoid Extracts from Agroresidues with Anxiolytic- and Antidepressant-like Effects in Mice |
| Honeysuckle | 📋 | | ⛔ | | 37863440 | Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice |
| Iodine | 📋 | ✍ | ⛔ | | 32802419 | The Relationship between Iodine and Selenium Levels with Anxiety and Depression in Patients with Euthyroid Nodular Goiter |
| Jasmine Essential Oil | 📋 | | | | 33723134 | In vitro cytotoxicity of cardamom oil, lemon oil, and jasmine oil on human skin, gastric, and brain cancer cell line |
| Jojoba Oil | 📋 | ✍ | ⛔ | | 33481197 | Ameliorative effects of jojoba oil on fipronil-induced hepatorenal- and neuro-toxicity: the antioxidant status and apoptotic markers expression in rats |
| Kale | 📋 | | | | 33540724 | Transepithelial Anti-Neuroblastoma Response to Kale among Four Vegetable Juices Using In Vitro Model Co-Culture System |
| Kava Root | 📋 | ✍ | ⛔ | | 11536390 | Kava and valerian in the treatment of stress-induced insomnia |
| Kimchi | 📋 | | ⛔ | | 35840231 | Kimchi intake alleviates obesity-induced neuroinflammation by modulating the gut-brain axis |
| L-Proline | 📋 | ✍ | ⛔ | | 27031721 | A Nutrient Mixture Inhibits Glioblastoma Xenograft U-87 MG Growth in Male Nude Mice |
| L-Threonine | 📋 | ✍ | ⛔ | | 33491030 | The Association between Dietary Amino Acid Intake and Cognitive Decline 8 Years Later in Japanese Community-Dwelling Older Adults |
| L-Tyrosine | 📋 | ✍ | ⛔ | | 10023508 | A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria |
| Laminaria | 📋 | ✍ | ⛔ | | 35394414 | Polysaccharides from laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation |
| Lemon | 📋 | | ⛔ | | 38016800 | Tomato and Lemon Extracts Synergistically Improve Cognitive Function by Increasing Brain-derived Neurotrophic Factor Levels in Aged Mice |
| Malva Sylvestris | 📋 | | ⛔ | | 32113847 | Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model |
| Mandarin | 📋 | | | | 33808343 | A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes |
| Metoprolol | 📋 | ✍ | ⛔ | | 36187012 | Baroreflex sensitivity predicts therapeutic effects of metoprolol on pediatric postural orthostatic tachycardia syndrome |
| Mint | 📋 | | ⛔ | | 34916937 | Anti-Hyperalgesic Properties of Menthol and Pulegone |
| MUFA | 📋 | | ⛔ | | 16256248 | Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian Longitudinal Study on Aging |
| Mustard | 📋 | | ⛔ | | 34856751 | Anti-Parkinson's evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals |
| Myrtle Essential Oil | 📋 | ✍ | ⛔ | | 35596201 | Chemical composition, antibiofilm, cytotoxic, and anti-acetylcholinesterase activities of Myrtus communis L. leaves essential oil |
| Oak Gall | 📋 | ✍ | ⛔ | | 34961052 | Gallotannin-Enriched Fraction from Quercus infectoria Galls as an Antioxidant and Inhibitory Agent against Human Glioblastoma Multiforme |
| Olive | 📋 | ✍ | ⛔ | | 34796529 | Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke-induced depressive-like behaviors in Sprague-Dawley rats |
| Papain | 📋 | ✍ | ⛔ | | 32122870 | Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes |
| Parsnip | 📋 | | ⛔ | | 32700246 | Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study |
| Phosphatidylcholine | 📋 | ✍ | ⛔ | | 34819604 | Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress |
| Pine Needle Essential Oil | 📋 | ✍ | ⛔ | | 33655878 | Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus |
| Pomelo | 📋 | | ⛔ | | 33390110 | Pomelo Peel Volatile Oil Alleviates Neuroinflammation on Focal Cerebral Ischemia Reperfusion Injury Rats via Inhibiting TLR4/NF-κB Signaling Pathway |
| Poria Mushrooms | 📋 | ✍ | | | 36374831 | Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on Aβ1-40-Induced Learning and Memory Deficit in Rats |
| Postbiotics | 📋 | | | | 37934614 | Gut microbiome-targeted therapies for Alzheimer's disease |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 28472734 | Comparative in Silico Analyses of Cannabis Sativa, Prunella Vulgaris and Withania Somnifera Compounds Elucidating the Medicinal Properties Against Rheumatoid Arthritis |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 38234695 | Ameliorative Potential of Pumpkin Seed Oil ( Cucurbita pepo L.) Against Tramadol-Induced Oxidative Stress |
| Salt | 📋 | | ⛔ | | 35788204 | Role of no table salt on hypertension and stroke based on large sample size from National Health and Nutrition Examination Survey database |
| Sandalwood Essential Oil | 📋 | | ⛔ | | 35325869 | Aromatherapy Massage for Relief of Pruritus and Stress in Older Women |
| Scutellarein | 📋 | | | | 37239029 | A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease |
| Sorghum | 📋 | | ⛔ | | 34690742 | Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer's Disease: A Review Article |
| Soy Protein | 📋 | ✍ | ⛔ | | 36561237 | Ameliorating Effect of Standardized Extract From Textured Soy Protein ( Glycine max L.) on Memory Deficit and Learning Insufficiency in Scopolamine-induced Amnesia |
| Spearmint | 📋 | | ⛔ | | 31646410 | Nicotine-induced oxidative stress, testis injury, AChE inhibition and brain damage alleviated by Mentha spicata |
| Spinach | 📋 | | ⛔ | | 30577447 | Effect of a Strawberry and Spinach Dietary Supplement on Spatial Learning in Early and Late Middle-Aged Female Rats |
| Star Fuit | 📋 | | ⛔ | | 30196278 | Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease |
| Sunflower Oil | 📋 | ✍ | ⛔ | | 37627620 | Ozonated Sunflower Oil Exerted Potent Anti-Inflammatory Activities with Enhanced Wound Healing and Tissue Regeneration Abilities against Acute Toxicity of Carboxymethyllysine in Zebrafish with Improved Blood Lipid Profile |
| Sweet Potato | 📋 | | ⛔ | | 35720655 | Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction |
| Tangerine | 📋 | | ⛔ | | 35100035 | Effects of Citrus depressa Hayata Fruit Extract on Thigh Muscles Mass and Composition in Subacute Stroke Patients: A Double-Blind, Randomized, Controlled Pilot Trial |
| Tea Tree Essential Oil | 📋 | | ⛔ | | 33468026 | Natural substances to potentiate canonical glioblastoma chemotherapy |
| Terpenoids | 📋 | | | | 35368757 | Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis |
| Theabrownins | 📋 | | | | 33995088 | Theabrownin Induces Cell Apoptosis and Cell Cycle Arrest of Oligodendroglioma and Astrocytoma in Different Pathways |
| Turnip | 📋 | | ⛔ | | 30560075 | Analgesic Effect of Valerian Root and Turnip Extracts |
| Vitamin K1 | 📋 | ✍ | ⛔ | | 35660920 | Inverse association between plasma phylloquinone and risk of ischemic stroke in Chinese adults with hypertension and high body mass index: a nested case-control study |
| Wasabi | 📋 | | ⛔ | | 35326132 | Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of Wasabia japonica |
| Wheat | 📋 | | ⛔ | | 34804895 | The effect of Triticum sativum (wheat) germ on postpartum pain: A double-blind clinical trial |
| White Mushrooms | 📋 | | ⛔ | | 36291298 | White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease |
| White Tea | 📋 | | ⛔ | | 21698507 | Neuroprotective effects of white tea against oxidative stress-induced toxicity in striatal cells |
| Wood Ear Mushrooms | 📋 | | ⛔ | | 31002628 | Role of Aqueous Extract of the Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), in Avoidance of Haloperidol-lnduced Catalepsy via Oxidative Stress in Rats |
| Yohimbine | 📋 | ✍ | | | 34889886 | Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments |
