| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Curcumin | 📋 | ✍ | ⛔ | | 40531286 | Neurobehavioral and Neuropathological Alterations Induced by Nickel Sulphate Toxicity in Rats: Molecular Mechanisms and Prophylaxis with Curcumin Supplementation |
| Cannabidiol | 📋 | ✍ | ⛔ | | 40484109 | Cannabidiol reverses microglia activation and loss of parvalbumin interneurons and perineuronal nets in a mouse model of schizophrenia |
| Melatonin | 📋 | ✍ | ⛔ | | 40536992 | Melatonin alleviates neuroinflammation in ischemic stroke by regulating cGAS-mediated microglial pyroptosis signaling |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 40542117 | Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats |
| Resveratrol | 📋 | ✍ | ⛔ | | 40507855 | Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease |
| Ginsenosides | 📋 | ✍ | ⛔ | | 40510292 | Ginsenoside C-K inhibits A? oligomer-induced Alzheimer's disease pathology progression by regulating microglia-neuron interactions |
| Quercetin | 📋 | ✍ | ⛔ | | 40520201 | Research progress of quercetin on anti-anxiety and anti-depression |
| Berberine | 📋 | ✍ | ⛔ | | 40482960 | Berberine's paradox in Neurodegeneration: Therapeutic promise and safety challenges in Parkinson's disease |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 40542117 | Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats |
| EGCG | 📋 | ✍ | ⛔ | | 40449273 | Epigollatecatechin gallate alleviates rheumatoid arthritis through PI3K-Akt pathway by inhibiting FLT1 |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 40537804 | EGb761 suppressed vascular dementia via modulating Wnt/β-catenin signaling pathway-induced apoptosis and autophagy in hippocampal neuronal cells |
| Vitamin C | 📋 | ✍ | ⛔ | | 40535041 | Vitamin C intake and cognitive function in older U.S. adults: nonlinear dose-response associations and effect modification by smoking status |
| Metformin | 📋 | ✍ | ⛔ | | 40531218 | Genetic insights into the effect of Metformin on psychiatry disorders |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 40484332 | Dietary alpha-lipoic acid prevents depression-like and anxiety-like behavior under aircraft noise exposure in young adult male mice |
| CoQ10 | 📋 | ✍ | ⛔ | | 40507939 | Traumatic Brain Injury and Coenzyme Q10: An Overview |
| Luteolin | 📋 | ✍ | ⛔ | | 40541584 | Untargeted metabolomics reveals the mechanisms of luteolin and exercise combination treatment against cognitive impairments in AD mice through modulating autophagy |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 40499198 | Vitamin B12 supplementation attenuates endoplasmic reticulum stress and neuronal cell death in the cerebral cortex of high-fat high-sucrose-fed male mice |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 39988721 | Acylcarnitines metabolism in depression: association with diagnostic status, depression severity and symptom profile in the NESDA cohort |
| Astaxanthin | 📋 | ✍ | ⛔ | | 40541974 | Astaxanthin attenuates DNA fragmentation and cognitive decline in type 2 diabetic rats |
| Citicoline | 📋 | ✍ | ⛔ | | 40255575 | The efficacy of different doses of citicoline in improving the prognosis of patients with acute ischemic stroke based on network meta-analysis |
| Astragalosides | 📋 | ✍ | ⛔ | | 40449268 | Astragaloside IV ameliorates Parkinson's disease by inhibiting TLR4/NF-?B-dependent neuroinflammation |
| Vitamin E | 📋 | ✍ | ⛔ | | 40529432 | L-shaped relationship between dietary vitamin E intake and migraine in adults: a cross-sectional analysis of NHANES 1999-2004 |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 40510771 | Current trends and future prospects of N-acetylcysteine utilizations in Parkinson's disease: A literature network analysis |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 40415367 | Docosahexaenoic Acid Attenuates Endoplasmic Reticulum Stress-Induced Neuron Apoptosis by Targeting Presenilin 2 |
| Sulforaphane | 📋 | ✍ | ⛔ | | 40339911 | Sulforaphane prevents cognitive decline and mitochondrial failure induced by hippocampal expression of caspase-3 cleaved tau |
| Ginseng | 📋 | ✍ | ⛔ | | 40453349 | Korean black ginseng extract alleviates Alzheimer's disease-related cognitive impairment by activating the Nrf2/HO-1 pathway and suppressing the p38 MAPK/NF-?B/STAT3 pathways and NLRP3 inflammasome via TLR2 and TLR4 modulation |
| Saffron | 📋 | ✍ | ⛔ | | 40455336 | Significance feature of saffron on testicular histomorphometry and expression profile of antioxidant enzymes in mice with induced multiple sclerosis: an in-vivo study |
| Micronutrients | 📋 | | ⛔ | | 40440029 | Supplement and nutraceutical therapy in traumatic brain injury |
| Magnesium | 📋 | ✍ | ⛔ | | 39590867 | Antioxidant Therapy in Neonatal Hypoxic Ischemic Encephalopathy: Adjuvant or Future Alternative to Therapeutic Hypothermia? |
| Salidroside | 📋 | | | | 40262718 | Protective effects of Salidroside against ferroptosis through PPARG-dependent mechanism in diabetes-related cognitive impairment |
| Hesperidin | 📋 | ✍ | ⛔ | | 40445481 | Neuroprotective Effects of Hesperidin and CK2 Inhibitor DRB on A?1-42-Induced Neurotoxicity in Differentiated SH-SY5Y Cells |
| Ashwagandha | 📋 | ✍ | ⛔ | | 40508211 | Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease |
| Crocin | 📋 | ✍ | ⛔ | | 40419073 | Crocin drives intestinal microbiota variation in a rat model of Alzheimer's disease by reducing DKK3 expression |
| Ginkgolides | 📋 | | | | 40522419 | A Cross-sectional In Vitro Study on the Synergistic Neuroprotective Effects of Phytochemicals Ferulic Acid and Ginkgolide B against Amyloid Beta-induced Oxidative Stress and Modulation of Multifunctional Enzyme APE1/Ref-1 in Human Neuroblastoma SH-SY5Y Cells |
| Medicinal Plants | 📋 | | | | 40516828 | Traditional Chinese herbal medicines for the treatment of ischemic stroke in China |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 40446132 | Clinical and Mechanistic Exploration of Ellagic Acid in Neurodegenerative Diseases: Targeted Neuroprotection Through Cellular and Molecular Mechanisms |
| Puerarin | 📋 | ✍ | ⛔ | | 40493135 | Puerarin Improves Cancer-Induced Bone Pain by Recovering Mitochondrial Dysfunction in the Spinal Cord |
| Apigenin | 📋 | ✍ | ⛔ | | 40430449 | The Immunomodulatory Effects of Apigenin and Quercetin on Cytokine Secretion by the Human Gingival Fibroblast Cell Line and Their Potential Link to Alzheimer's Disease |
| Genistein | 📋 | ✍ | ⛔ | | 40124394 | Genistein improves depression-like behavior in rats by regulating intestinal flora and altering glutamate gene expression |
| Naringenin | 📋 | ✍ | ⛔ | | 40486726 | Promising neuroprotective potential of naringenin against trimethyltin-induced cognitive deficits and hippocampal neurodegeneration in rats |
| Phytochemicals | 📋 | | | | 40426956 | Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora |
| Food | 📋 | | | | 40391017 | From prevention to management: Exploring the impact of diet on multiple sclerosis |
| Baicalin | 📋 | ✍ | ⛔ | | 40461422 | Baicalin protects neurons from oxidative stress and apoptosis induced by glutamate excitotoxicity in HT-22 cells |
| Thymoquinone | 📋 | | ⛔ | | 40340641 | Effect of thymoquinone on hippocampal spexin levels in cisplatin-induced rats |
| Baicalein | 📋 | ✍ | ⛔ | | 40490169 | Therapeutic potential of flavonoids against ?-synuclein aggregation in Parkinson's Disease: Integrative in silico and in vitro analysis |
| Fisetin | 📋 | ✍ | ⛔ | | 40529017 | Fisetin-mediated PPAR-? upregulation: a novel therapeutic approach for corpus cavernosum smooth-muscle-cell apoptosis and restoration of erectile function after cavernous nerve injury |
| Selenium | 📋 | ✍ | ⛔ | | 40398250 | Transcriptomics and metabolomics reveal the mechanism of cognitive impairment induced by long-term selenium deficiency in mice |
| Rutin | 📋 | ✍ | ⛔ | | 40529506 | Molecular mechanisms of neuroprotective effect of rutin |
| Icariin | 📋 | ✍ | | | 40481799 | Icariin Supplementation Alleviates Cognitive Impairment Induced by d-Galactose via Modulation of the Gut-Brain Axis |
| Lycopene | 📋 | ✍ | ⛔ | | 40489694 | The Phagocytic Receptor MERTK Mediates Lycopene's Ameliorative Effects on Atrazine-Induced Microglial Efferocytosis Dysfunction |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 40218925 | Vitamin D, B9, and B12 Deficiencies as Key Drivers of Clinical Severity and Metabolic Comorbidities in Major Psychiatric Disorders |
| TUDCA | 📋 | ✍ | ⛔ | | 40490087 | Tauroursodeoxycholic acid reduces brain lesion volume and cortical edema in a rat model of Traumatic brain injury |
| Capsaicin | 📋 | ✍ | ⛔ | | 40517340 | Progressive Response of Repeated Treatment with High-Concentration (179 mg) Capsaicin Patch in Peripheral Neuropathic Pain After Surgical or Traumatic Nerve Injury: Findings from the 12-Month German CASPAR Registry Study |
| Goji Berry | 📋 | ✍ | ⛔ | | 40445437 | Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro |
| Andrographolide | 📋 | | | | 40274350 | Andrographolide sulfonate alleviates rheumatoid arthritis by inhibiting glycolysis-mediated activation of PI3K/AKT to restrain Th17 cell differentiation |
| Caffeine | 📋 | ✍ | ⛔ | | 40507194 | Caffeine: A Neuroprotectant and Neurotoxin in Traumatic Brain Injury (TBI) |
| Chrysin | 📋 | ✍ | ⛔ | | 40187596 | Chrysin's Anti-Inflammatory Action in the Central Nervous System: A Scoping Review and an Evidence-gap mapping of its Mechanisms |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 40522419 | A Cross-sectional In Vitro Study on the Synergistic Neuroprotective Effects of Phytochemicals Ferulic Acid and Ginkgolide B against Amyloid Beta-induced Oxidative Stress and Modulation of Multifunctional Enzyme APE1/Ref-1 in Human Neuroblastoma SH-SY5Y Cells |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 40496446 | Effects of a home-based aromatherapy programme for the management of behavioural and psychological symptoms of dementia among older persons with dementia: A randomised controlled trial with process evaluation |
| Naringin | 📋 | ✍ | ⛔ | | 40462169 | The increase in autophagy induced by naringin alleviates Schwann cell apoptosis mediated by the AMPK/mTOR signalling pathway |
| Pterostilbene | 📋 | ✍ | ⛔ | | 40518087 | TREX1 activators: A novel therapeutic strategy for rheumatoid arthritis management via cfDNA clearance |
| NMN | 📋 | ✍ | ⛔ | | 39422945 | Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach |
| Polyphenols | 📋 | | | | 40456409 | Polyphenol intake and risk for dementia and cognitive decline in the elderly population of Greece: A principal component analysis approach |
| Probiotics | 📋 | ✍ | ⛔ | | 40495848 | Gut-brain connection in schizophrenia: A narrative review |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 40299018 | A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women |
| Zinc | 📋 | ✍ | ⛔ | | 40491365 | Exploring the Neuroprotective Potential of Polyphenolic Compounds in Mitigating Quinolinic Acid-Induced Neurotoxicity in Alzheimer's Disease |
| Fish Oil | 📋 | ✍ | ⛔ | | 40414709 | Full spectrum cannabis oil combined with omega-3 fish oil for neuropathic pain management: a novel therapeutic approach |
| Gotu Kola | 📋 | ✍ | ⛔ | | 40204151 | Neuroprotective effects of Centella asiatica against LPS/amyloid beta-induced neurodegeneration through inhibition of neuroinflammation |
| Kaempferol | 📋 | ✍ | ⛔ | | 40298627 | Kaempferol ameliorated central nervous injury induced by alcohol uptake through improving intestinal barrier function |
| Piperine | 📋 | ✍ | ⛔ | | 39812529 | Piperine relieves neuropathic pain induced by paclitaxel in mice |
| Paeoniflorin | 📋 | | | | 40427467 | Paeoniflorin Alleviates Lipopolysaccharide-Induced Neuroinflammation and Depression Through the Keap1/Nrf2/HO-1 Signaling Pathway |
| Schisandra | 📋 | ✍ | ⛔ | | 40471999 | Exploring the Effects of Effective Parts of Schisandra sphenanthera on the Gut-Brain Axis of Type 2 Diabetes Mellitus Rats Based on Metabolomic and Proteomic Approaches |
| Antioxidants | 📋 | | ⛔ | | 40497994 | Antioxidant Bioactive Agents for Neuroprotection Against Perinatal Brain Injury |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 39907901 | Grape Seed Extract Pretreatment Prevents Mitochondrial Dysfunction and NLRP3 Inflammasome-Induced Inflammatory Response in Glial Cells Exposed to Paroxetine and Quinolinic Acid |
| Nobiletin | 📋 | ✍ | | | 40277409 | Ultrastructural testicular damage by water avoidance stress: therapeutic effects of nobiletin |
| Rosmarinic Acid | 📋 | ✍ | | | 40481731 | Rosmarinic acid attenuates photophobia, hyperalgesia and neuroinflammation during nitroglycerine induced migraine like headache in mice |
| Carvacrol | 📋 | ✍ | ⛔ | | 40465192 | Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease |
| Fucoidan | 📋 | ✍ | ⛔ | | 40186245 | Fucoidan reduces NET accumulation and alleviates chemotherapy-induced peripheral neuropathy via the gut-blood-DRG axis |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 40126708 | In vivo and in silico analysis of anti inflammatory, antipyretic and analgesic activity of methanolic extract of Nigella sativa |
| Tanshinone | 📋 | | | | 40513327 | Preventive and therapeutic effects of Tanshinone IIA on spinal cord injury without radiographic abnormality by regulating microglial phenotype polarization |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 39957299 | Nicotinamide riboside alleviates sweeteners-induced brain and cognitive impairments in immature mice |
| Emodin | 📋 | | ⛔ | | 40388860 | Emodin delays rheumatoid arthritis progression by inhibiting the ROS/TXNIP/NLRP3 signaling pathway |
| Flavonoids | 📋 | | ⛔ | | 40490174 | The relationship between flavonols intake and stroke in the elderly: a cross-sectional study from NHANES (2007-2010 and 2017-2018) |
| Ginger | 📋 | ✍ | ⛔ | | 40429970 | Network Pharmacology-Guided Evaluation of Ginger and Cornelian Cherry Extracts Against Depression and Metabolic Dysfunction in Estrogen-Deficient Chronic Stressed Rats |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 40346511 | Identifying suppressive factors of Alzheimer's disease through comprehensive analysis of real-world data: a single-center retrospective study |
| Silymarin | 📋 | ✍ | ⛔ | | 40193019 | Evaluating the Protective Effects of Silymarin Along with a Cholesterol-Supplemented Diet Against Demyelination in an EAE Mouse Model of Multiple Sclerosis: Lipidomic and Inflammatory Aspects |
| Blueberry | 📋 | ✍ | ⛔ | | 40420577 | Individual and combined walnut oil and blueberry attenuate lipopolysaccharide-induced neuroinflammation in rat microglia |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 40243772 | Neuroprotective Effects of Cilomilast and Chlorogenic Acid Against Scopolamine-Induced Memory Deficits via Modulation of the cAMP/PKA-CREB-BDNF Pathway |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 40418429 | Study on the Mechanism of Dihydromyricetin in Alleviating Depressive-Like Behavior in Rats Based on Network Pharmacology |
| Gallic Acid | 📋 | | ⛔ | | 40112248 | Gallic acid relieved bortezomib-induced peripheral neurotoxicity by restoring Schwann cell lysosomal activity |
| L-Theanine | 📋 | ✍ | ⛔ | | 40504752 | Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice |
| Salvianolic Acid | 📋 | | | | 40522382 | Neuroprotective Effect of Salvianolic Acid C in Neonatal Rats Following Hypoxic-ischemic Brain Damage |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 40455220 | Effects of Ganoderma lucidum polysaccharide on learning and memory impairment and intestinal flora in mice with D-galactose-induced aging |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 40232525 | Investigate the protective effects of eicosapentaenoic acid in human astrocytes of oxidative stress damage and explore its underlying mechanisms |
| Mangiferin | 📋 | | ⛔ | | 40379124 | Mangiferin: A natural neuroprotective polyphenol with anti-inflammatory and anti-oxidant properties for depression |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 40448817 | Exploring the therapeutic role of Moringa oleifera in neurodegeneration: antioxidant, anti-inflammatory, and neuroprotective mechanisms |
| Taurine | 📋 | ✍ | ⛔ | | 40361025 | Unveiling taurine's protective role in ischemic stroke: insights from bidirectional Mendelian randomization and LC-MS/MS analysis |
| Frankincense | 📋 | ✍ | ⛔ | | 39973246 | The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial |
| Pomegranate | 📋 | | ⛔ | | 39997528 | Impact of Pomegranate Extract Supplementation on Physical and Cognitive Function in Community-Dwelling Older Adults Aged 55-70 Years: A Randomised Double-Blind Clinical Trial |
| Allicin | 📋 | ✍ | ⛔ | | 40396992 | Alliin from garlic as a neuroprotective agent attenuates ferroptosis in vitro and in vivo via inhibiting ALOX15 |
| Irisin | 📋 | | | | 40539755 | Association between circulating irisin level and depression: a systematic review and meta-analysis |
| Oleuropein | 📋 | | | | 39157939 | Pretreatment with oleuropein protects the neonatal brain from hypoxia-ischemia by inhibiting apoptosis and neuroinflammation |
| Hydroxytyrosol | 📋 | | | | 40384030 | Hydroxytyrosol Inhibits BPS-Induced NF-?B Signaling Pathway Activation, Mitigates Oxidative Stress, and Reduces Neuronal Apoptosis |
| Panax Notoginseng | 📋 | ✍ | ⛔ | | 40289951 | Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
| PEA | 📋 | ✍ | ⛔ | | 40427076 | Effective Management of Chronic Low Back Pain in the Elderly: A One-Year Cohort Study of Oxygen-Ozone Therapy Under CT Guidance Combined with Alpha Lipoic Acid, Palmitoylethanolamide, and Myrrh |
| Urolithins | 📋 | | | | 40449618 | Neuroprotective effects of urolithin a in a mouse model of intracerebral hemorrhage |
| Gingerol | 📋 | ✍ | | | 40440961 | 6-Gingerol overcomes TMZ resistance in GBM by suppressing EMT and cell migration via the PI3K/Akt/β-catenin/c-Myc pathway |
| L-Carnitine | 📋 | ✍ | ⛔ | | 40540007 | Effects of L-carnitine on aging-related learning changes and glutamate-mediated molecular mechanisms |
| Olive Oil | 📋 | ✍ | ⛔ | | 40002358 | Extra Virgin Olive Oil Polyphenol-Enriched Extracts Exert Antioxidant and Anti-Inflammatory Effects on Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients |
| Asiatic Acid | 📋 | | | | 40465752 | Radioprotective effects of asiaticoside and asiatic acid in neural stem cells derived from human stem cells from apical papilla through increasing dose-reduction factor and their lowering effects on SH-SY5Y cell viability |
| Catalpol | 📋 | | | | 40245961 | IGF-1 signaling pathway activation promotes axonal regeneration and repair: A mechanism study on catalpol-induced functional recovery after ischemic stroke |
| Formononetin | 📋 | | | | 40377696 | Protective effect of formononetin in chronic unpredictable stress (CUS) linked to parkinson disease |
| Geniposide | 📋 | | | | 40257488 | Geniposide protects against cerebral ischemic injury by targeting SOX2/RIPK1 axis |
| Silibinin | 📋 | ✍ | | | 39986195 | Silybin attenuates microglia-mediated neuroinflammation via inhibition of STING in experimental subarachnoid hemorrhage |
| Carnosic Acid | 📋 | | | | 39826355 | Co-delivery of curcumin-resveratrol-carnosic acid complex promotes neurogenesis and cognitive recovery in a rodent model of repeated mild traumatic brain injury |
| Folate | 📋 | ✍ | ⛔ | | 39533580 | Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study |
| Licorice Root | 📋 | ✍ | ⛔ | | 39757620 | Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer's Disease |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 39812531 | Response of miRNA to treatment with Hypericum perforatum L. oil in multiple sclerosis |
| Bee Venom | 📋 | ✍ | ⛔ | | 38735618 | Amelioration of melittin on adjuvant-induced rheumatoid arthritis: Integrated transcriptome and metabolome |
| Coffee | 📋 | ✍ | ⛔ | | 40286889 | Coffee consumption and risk of multiple sclerosis: A systematic review and meta-analysis |
| Green Tea | 📋 | ✍ | ⛔ | | 40298836 | Green Tea Intake Reduces High-Fat Diet-Induced Sensory Neuropathy in Mice by Upregulating the Antioxidant Defense System in the Spinal Cord |
| Hesperetin | 📋 | | | | 40200061 | A tardive dyskinesia drug target VMAT-2 participates in neuronal process elongation |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 40395549 | The relationship between dietary vitamin B1 and stroke: a machine learning analysis of NHANES data |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 39806460 | Boswellic acid synergizes with low-dose ionizing radiation to mitigate thioacetamide-induced hepatic encephalopathy in rats |
| Cinnamon | 📋 | ✍ | ⛔ | | 40259962 | Cinnamon pretreatment modulates gene expression of tight junction proteins in a rat model of stroke |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 40325616 | Microalgae-Based Fucoxanthin Attenuates Rheumatoid Arthritis by Targeting the JAK-STAT Signaling Pathway and Gut Microbiota |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 40487229 | Revolutionizing nerve regeneration: A novel approach using polylactic acid/chitosan conduit with nerve-like cells and Bacopa monnieri in male rat model |
| Lutein | 📋 | ✍ | ⛔ | | 40194634 | Lutein and Zeaxanthin abated neurobehavioral, neurochemical and oxido-inflammatory derangement in rats intoxicated with Aflatoxin B1 |
| Spirulina | 📋 | ✍ | ⛔ | | 40332553 | Unveiling the pharmacological mechanisms of Spirulina platensis in rheumatoid arthritis rats through the integration of serum metabolomics, pathways analysis, and experimental validation |
| Coconut Oil | 📋 | | ⛔ | | 39446626 | Effects of Krill Oil and Coconut Oil on Inflammatory Processes in Rats With Chronic Unpredictable Mild Stress-Induced Depression and Obesity Model |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 39956389 | Protection of Green Tea Polyphenols against Neurodegenerative Diseases: Evidence and Possible Mechanisms |
| Walnut | 📋 | | ⛔ | | 40420577 | Individual and combined walnut oil and blueberry attenuate lipopolysaccharide-induced neuroinflammation in rat microglia |
| Galangin | 📋 | | | | 40540149 | Exploring the pharmacological mechanisms and therapeutic implications of galangin against neurological disorders |
| Rapamycin | 📋 | ✍ | | | 38640155 | Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies |
| Vitamin B Complex | 📋 | | ⛔ | | 40332575 | Updated Meta-Analysis on Vitamin Supplementation for Chronic Pruritus: Expanding Evidence Beyond Vitamin D |
| Astragalus Root | 📋 | ✍ | ⛔ | | 40335326 | Astragalus Polysaccharide Alleviates Cognitive Decline in D-Galactose-Induced Aging |
| Cocoa | 📋 | ✍ | ⛔ | | 40158278 | Combining vinpocetine or cocoa with levodopa, Coenzyme Q10 and vitamin B complex mitigates rotenone-induced Parkinson's disease in rats: Impact on Nrf2/HO-1, NF-kB, AMPK/SIRT-1/Beclin-1, AKT/GSK-3?/CREB/BDNF and Apoptotic Pathways |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 39585054 | The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer's Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 40508225 | Ursolic Acid-Based Nutraceutical Mitigates Muscle Atrophy and Improves Exercise Performance in Mouse Model of Peripheral Neuropathy |
| Catechins | 📋 | | | | 40195186 | ( +)-Catechin Alleviates CCI-Induced Neuropathic Pain by Modulating Microglia M1 and M2 Polarization via the TLR4/MyD88/NF-?B Signaling Pathway |
| Diosmin | 📋 | ✍ | ⛔ | | 40261347 | Behavioral deficits after traumatic brain injury: Neuroprotective effect of Diosmin |
| Honokiol | 📋 | | | | 40481059 | Inhibition of levodopa metabolism to dopamine by honokiol short-chain fatty acid derivatives may enhance therapeutic efficacy in Parkinson's disease |
| Myricetin | 📋 | | ⛔ | | 40383467 | Mechanism of flavonoid myricetin modulated aggregation in ?-Synuclein and its familial mutants E46K and A30P |
| Peony | 📋 | | ⛔ | | 40374370 | Neuroprotective Effects of Paeonia lactiflora Through the Regulation of Gut Dubosiella in an MPTP-Induced Parkinson's Disease Mouse Model |
| Isoliquiritigenin | 📋 | | | | 40414556 | Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimer's disease |
| Punicalagin | 📋 | ✍ | ⛔ | | 39823794 | Punicalagin inhibits neuron ferroptosis and secondary neuroinflammation to promote spinal cord injury recovery |
| Tea | 📋 | | | | 39737152 | Coffee and tea consumption and glioma risk: a meta-analysis of cohort studies |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 40411246 | Systematic Review Suggests Nutraceuticals Containing Vitamin B2 Could Provide an Alternative Treatment for Paediatric Migraines |
| Bee Propolis | 📋 | ✍ | ⛔ | | 40333577 | Nature's Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson's Disease |
| Carotenoids | 📋 | ✍ | ⛔ | | 39834456 | Association between serum carotenoids levels and severe headache or migraine in adults: a cross-sectional study from NHANES |
| L-Carnosine | 📋 | ✍ | ⛔ | | 39933073 | Carnosine Mitigates Cognitive Impairment and Dopamine Release in an Okadaic Acid-Induced Zebrafish Model with Alzheimer's Disease-like Symptoms |
| Spikenard | 📋 | ✍ | ⛔ | | 40358168 | Nardostachys jatamansi Extract and Nardosinone Exert Neuroprotective Effects by Suppressing Glucose Metabolic Reprogramming and Modulating T Cell Infiltration |
| Aged Garlic | 📋 | ✍ | ⛔ | | 38923108 | Anti-inflammatory and anti-hyperalgesic effects induced by an aqueous aged black garlic extract in rodent models of ulcerative colitis and colitis-associated visceral pain |
| Artemisinin | 📋 | | | | 39795253 | Artemisinin Stimulates Neuronal Cell Viability and Possess a Neuroprotective Effect In Vitro |
| Asiaticoside | 📋 | | | | 40384087 | Infralimbic GABAergic May be the Target of Asiaticoside on Alleviating Bone Cancer Pain |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 40298618 | Investigating Bergamot Essential Oil (BEO) Properties: Cytoprotection in Neuronal Cells Exposed to Heavy Metals and Antibacterial Activities |
| Mulberry | 📋 | | ⛔ | | 40430516 | Research Progress on Phytochemicals from Mulberry with Neuroprotective Effects: A Review |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 40092451 | Neuroprotective and antioxidant effects of Urtica dioica extract against chlorpyrifos-induced toxicity: an in vivo study |
| Tangeretin | 📋 | | | | 40220719 | Tangeretin protects against A?1-42-induced toxicity and exploring mitochondria-lysosome interactions in HT22 cells |
| Angelica | 📋 | ✍ | ⛔ | | 39889994 | The interaction between Angelica sinensis polysaccharide ASP-2pb and specific gut bacteria alleviates rheumatoid arthritis in rats |
| Bromelain | 📋 | ✍ | ⛔ | | 40491365 | Exploring the Neuroprotective Potential of Polyphenolic Compounds in Mitigating Quinolinic Acid-Induced Neurotoxicity in Alzheimer's Disease |
| Cinnamaldehyde | 📋 | | | | 40381675 | Cinnamaldehyde enhances the intervention effect of puerarin on stroke from the perspectives of pharmacokinetics and pharmacodynamics |
| Cordycepin | 📋 | | | | 40202221 | Exploring Cordycepin as a Neuroprotective Agent in Huntington's Disease: In Vitro and In Vivo Insights |
| Dihydroquercetin | 📋 | | | | 39756058 | Dihydroquercetin Ameliorates Neuronal Ferroptosis in Rats After Subarachnoid Hemorrhage via the PI3K/AKT/Nrf2/HO-1 Pathway |
| Essential Oils | 📋 | | ⛔ | | 39921369 | Treatments of psychosomatic symptoms in Alzheimer's disease: a scoping review of the potential therapeutic effects of essential oils |
| Eugenol | 📋 | | | | 39810258 | Regulatory roles of eugenol in paraquat-altered SNCA/LZTS3/MAPT in the cerebellum of Wistar rats |
| Ginger extract | 📋 | ✍ | ⛔ | | 40129204 | Investigation of the Protective and Therapeutic Effects of Ginger (Zingiber officinale) Extracts on Neuroinflammatory, Motor and Cognitive Impairments Caused by Mild Traumatic Brain Injury Model |
| Ligustilide | 📋 | | | | 39247814 | Enhancing mitophagy by ligustilide through BNIP3-LC3 interaction attenuates oxidative stress-induced neuronal apoptosis in spinal cord injury |
| Arctigenin | 📋 | | | | 38104254 | Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism |
| Crocetin | 📋 | | | | 39092730 | Crocetin Enhances Temozolomide Efficacy in Glioblastoma Therapy Through Multiple Pathway Suppression |
| Magnolol | 📋 | | | | 40057167 | Magnolol protects C6 glioma cells against neurotoxicity of FB1 via modulating PI3K/Akt and mitochondria-associated apoptosis signaling pathways |
| Turmeric | 📋 | ✍ | ⛔ | | 39973246 | The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial |
| Anthocyanins | 📋 | ✍ | ⛔ | | 39477625 | Improvement of chlorpyrifos-induced cognitive impairment by mountain grape anthocyanins based on PI3K/Akt signaling pathway |
| Daidzein | 📋 | ✍ | ⛔ | | 40359691 | Daidzein effectively mitigates amyloid-β-induced damage in SH-SY5Y neuroblastoma cells and C6 glioma cells |
| Ganoderic Acid | 📋 | | | | 40328991 | Effects of different doses of Ganoderic Acid A on nociceptive behaviour and inflammatory parameters in polyarthritic mice rheumatoid arthritis model |
| Indian Gooseberry | 📋 | | ⛔ | | 40527496 | Phyllanthin from Phyllanthus amarus exerts neuroprotective effects against spinal cord injury in experimental rats |
| Pine Bark | 📋 | ✍ | ⛔ | | 36153882 | Pycnogenol® supplementation alleviates symptoms of Parkinson's disease with mild cognitive impairment |
| Prebiotics | 📋 | ✍ | ⛔ | | 40495848 | Gut-brain connection in schizophrenia: A narrative review |
| Rosemary | 📋 | ✍ | ⛔ | | 40274198 | Combating depression with rosemary (Rosmarinus officinalis L.)-derived polyphenols: Major phytochemicals, functional properties, and potential |
| Scutellarin | 📋 | | | | 40232642 | Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia |
| Valerian Root | 📋 | ✍ | ⛔ | | 40271501 | The effect of Valeriana officinalis tea on sympathovagal tone and cardiac function in healthy volunteers: A semi-experimental study |
| Betaine | 📋 | ✍ | ⛔ | | 40530574 | Betaine protects cerebral microvascular endothelium and ameliorates hypertension-induced cognitive dysfunction via upregulation of the endothelial nitric oxide synthase/nitric monoxide signaling pathway |
| DHEA | 📋 | ✍ | ⛔ | | 40437391 | Androgens alleviate the depression-like phenotype in female mice by inhibiting AVPR1a in the hippocampal brain region |
| Schisandrins | 📋 | | | | 40382817 | Schisandrin B ameliorates Alzheimer's disease by suppressing neuronal ferroptosis and ensuing microglia M1 polarization |
| Vitamin A | 📋 | ✍ | ⛔ | | 40538773 | Vitamin A attenuates PFOS-induced neurotoxicity and alters early proximity patterns to conspecifics in zebrafish larvae |
| Echinacoside | 📋 | | | | 40233432 | Integrated bioinformatics and experimental verification to dissect the mechanisms and bioactive ingredients of Radix Rehmanniae in treating multiple sclerosis |
| Licochalcones | 📋 | | | | 40311879 | Neuroprotective effect of Licochalcone A against aluminum chloride-induced neurotoxicity by reducing A? accumulation, oxidative stress and inflammatory reaction |
| Senolytics | 📋 | | | | 40336246 | Senolytic treatment to rescue hallmarks of senescence in lymph node fibroblasts from patients with rheumatoid arthritis: Implications for premature aging and potential therapeutic intervention in early rheumatoid arthritis |
| Skullcap | 📋 | ✍ | ⛔ | | 40077679 | The Effects of Combined Scutellaria and Saffron Supplementation on Mood Regulation in Participants with Mild-to-Moderate Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 40042369 | The analgesic effect of total saponins of Tribulus terrestris on neuropathic pain was studied based on TLR4/NF-?B pathway |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 40515875 | Multitarget neuroprotective effects of ?-sitosterol in diabetes-associated neurodegeneration: a coupled experimental/computational study |
| Butyrate | 📋 | | ⛔ | | 40224959 | Higher dietary butyrate intake is associated with better cognitive function in older adults: evidence from a cross-sectional study |
| CAPE | 📋 | | | | 39858474 | Caffeic Acid Phenethyl Ester Protects Neurons Against Oxidative Stress and Neurodegeneration During Traumatic Brain Injury |
| Fish | 📋 | | ⛔ | | 40219009 | Extent of Unidentified Complaints and Depression Is Inversely Associated with Fish and Shellfish Intake in Young Japanese Women |
| Garlic | 📋 | ✍ | ⛔ | | 40512569 | Therapeutic and Biological Properties of White Garlic and Black Garlic Extracts (Allium sativum L.): A Comparative Analysis |
| Icaritin | 📋 | | | | 40318814 | Icaritin Promotes Brain Functional Rehabilitation in Ischemic Stroke Rats by Regulating Astrocyte Activation and Polarization Via GPER |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 36159806 | Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders |
| Lemon Balm | 📋 | ✍ | ⛔ | | 39467696 | Melissa officinalis Regulates Lipopolysaccharide-Induced BV2 Microglial Activation via MAPK and Nrf2 Signaling |
| Morin | 📋 | | | | 40524867 | Morin Mitigates Methamphetamine-Induced Neurotoxicity: Effects on Motor and Cognitive Function |
| Paeonol | 📋 | | | | 40465192 | Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease |
| Polydatin | 📋 | ✍ | | | 40313624 | Polydatin attenuates Alzheimer's disease induced by aluminum chloride in rats: evidence for its antioxidant and anti-inflammatory effects |
| Telmisartan | 📋 | | ⛔ | | 40541176 | Telmisartan is neuroprotective in a hiPSC-derived spinal microtissue model for C9orf72 ALS via inhibition of neuroinflammation |
| Acai Berry | 📋 | ✍ | ⛔ | | 37584088 | Açai Berry Ameliorates Cognitive Impairment by Inhibiting NLRP3/ASC/CASP axis in STZ-Induced Diabetic Neuropathy in Mice |
| Bilobalide | 📋 | | | | 40518087 | TREX1 activators: A novel therapeutic strategy for rheumatoid arthritis management via cfDNA clearance |
| Choline | 📋 | ✍ | ⛔ | | 40447055 | Dietary Choline Intake and Risk of Alzheimer's Dementia in Older Adults |
| Diosgenin | 📋 | | | | 40480021 | Diosgenin promoted OPCs differentiation via blocking GLUR2/GAPDH interaction in a pilocarpine rat model of epilepsy |
| L-Arginine | 📋 | ✍ | ⛔ | | 39326233 | L-arginine mitigates choroid plexus changes in Alzheimer's disease rat model via oxidative/inflammatory burden and behavioral modulation |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 40413998 | Hericium erinaceus extracts promote neuronal differentiation and excitability through nootropic metabolite activity |
| Olive Polyphenols | 📋 | | | | 39482909 | Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load |
| Progesterone | 📋 | ✍ | ⛔ | | 40532869 | The effects of progesterone administration and pre-training on learning & memory, anxiety-like behaviors, and balance impairments following traumatic brain injury in male rats: The role of neuroinflammation |
| Stigmasterol | 📋 | | | | 39947740 | Focusing on Keap1, IKKβ, and Bcl2 proteins: predicted targets of stigmasterol in neurodegeneration |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 40292259 | Protective role of zeaxanthin on acrylamide-induced neurotoxicity in Wistar rats |
| 5-HTP | 📋 | ✍ | ⛔ | | 37421347 | Effects of adjuvant berberine therapy on acute ischemic stroke: A meta-analysis |
| Escin | 📋 | ✍ | ⛔ | | 40095493 | Pharmacological Evaluation of Aescin for Neuroprotection in Intracerebroventricular Streptozotocin Model of Alzheimer's Disease in Experimental Rats |
| Gardenia | 📋 | | ⛔ | | 40398000 | Gardeniae Fructus extract terminates refractory status epilepticus with a wide time window through inhibiting neuroinflammation |
| Hyperoside | 📋 | | | | 39716641 | Hyperoside ameliorates neuropathic pain by modulating the astroglial reactivity in the vlPAG |
| Linalool | 📋 | | ⛔ | | 40055204 | Anti-arthritic potential of linalool: in vitro, in vivo, and in silico mechanistic insights for safer therapeutic applications |
| Thymol | 📋 | ✍ | ⛔ | | 39540984 | Neuroprotective Effects of Thymol and p-Cymene in Immobilized Male rats through Alterations in Molecular, Biochemical, Histological, and Behavioral Parameters |
| Trehalose | 📋 | | ⛔ | | 37542649 | Metformin and Trehalose-Modulated Autophagy Exerts a Neurotherapeutic Effect on Parkinson's Disease |
| Calycosin | 📋 | | | | 40260589 | Therapeutic Targets and Molecular Mechanisms of Calycosin in the Treatment of Depression: Insights From Chronic Mild Stress Animal Models |
| Geraniol | 📋 | | | | 39654600 | Geraniol Ameliorates Pentylenetetrazol-Induced Epilepsy, Neuroinflammation, and Oxidative Stress via Modulating the GABAergic Tract: In vitro and in vivo studies |
| Grape | 📋 | | ⛔ | | 39340661 | Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation |
| Holy Basil | 📋 | ✍ | ⛔ | | 37141281 | Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic-pituitary-adrenal (HPA) axis in modulating stress |
| NAD | 📋 | | | | 40320991 | Nicotinamide Adenine Dinucleotide Supplementation Improves Cuprizone-Induced Multiple Sclerosis-Related Behavioral Changes in C57BL/6J Mice |
| PUFA | 📋 | | | | 40048675 | Anti-arthritic effects of polyunsaturated fatty acid rich supplementation combined with selective soluble epoxide hydrolase inhibitors in a collagen-induced arthritis mouse model |
| Vitexin | 📋 | | | | 40388859 | Vitexin mitigates AIM2 inflammasome-mediated mitochondrial dysfunction and neuroinflammation in chronic constriction injury induced neuropathy model |
| Wogonin | 📋 | ✍ | ⛔ | | 40444042 | Wogonin inhibits the proliferation of prolactinoma through the PI3K/AKT signaling pathway |
| Creatine | 📋 | ✍ | ⛔ | | 40395689 | Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition |
| Mangosteen | 📋 | ✍ | ⛔ | | 36552604 | Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson's Disease |
| Nicotinamide | 📋 | ✍ | ⛔ | | 39671543 | Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease |
| Spermidine | 📋 | | | | 40503490 | Spermidine Exerts Neuroprotective Effects Following Intracerebral Hemorrhage in Mice Through Anti-Inflammation and Blood-Brain Barrier Protection |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 39926607 | Niacin ameliorates Charcot-Marie-Tooth 4B1 neuropathy without interfering with nerve regeneration |
| Vitamins | 📋 | | | | 39944951 | Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels |
| Withaferin A | 📋 | | | | 40479066 | Vimentin network dysregulation mediates neurite deficits in SNCA duplication Parkinson's patient-derived midbrain neurons |
| Aspirin | 📋 | | ⛔ | | 39920681 | The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study |
| Biochanin A | 📋 | | | | 40012390 | Biochanin-A: A Potential Candidate for the Treatment of Alzheimer's Disease |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 40440968 | Topical chamomile oil as a novel therapeutic intervention for diabetic neuropathy: A randomized double-blind controlled clinical trial |
| Coriander | 📋 | | ⛔ | | 37513187 | Coriandrum sativum and Its Utility in Psychiatric Disorders |
| Neferine | 📋 | | | | 40262197 | Neferine reduces synovial inflammation and cardiac complications in a collagen-induced arthritis mouse model via inhibiting NF-?B/NLRP3 inflammasome axis |
| Parthenolide | 📋 | | | | 40100917 | Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 35164175 | Healthy Properties of a New Formulation of Pomegranate-Peel Extract in Mice Suffering from Experimental Autoimmune Encephalomyelitis |
| Red Sage | 📋 | ✍ | ⛔ | | 40456474 | Proteomics based discovery of Salvia miltiorrhiza Bunge treating Parkinson's disease through the PINK1/Parkin pathway |
| Vitamin K | 📋 | ✍ | ⛔ | | 40428819 | Exploring the Link Between Vitamin K and Depression: A Systematic Review |
| Withanolides | 📋 | | | | 39721456 | The total withanolides from the leaves of Datura stramonium L. Improves Alzheimer's disease pathology by restraining neuroinflammation through NLRP3/IL-1β/IL1R1/TOM 1 pathway |
| Aloe Vera | 📋 | ✍ | ⛔ | | 40203444 | Effect of Aloe vera on brain indoleamine 2, 3 dioxygenase activity and tissue antioxidant status in rats subjected to swim stress |
| Aloe-Emodin | 📋 | | | | 40125832 | Aloe-Emodin Improves Mitophagy in Alzheimer's Disease via Activating the AMPK/PGC-1α/SIRT3 Signaling Pathway |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 40269665 | Alpha-Linolenic Acid for Mitigating Neuroinflammation and Dopaminergic Neuronal Loss in Parkinson's Disease: Insights From In Vivo and In Silico Studies |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 37259308 | Reversal of Neuralgia Effect of Beta Carotene in Streptozotocin-Associated Diabetic Neuropathic Pain in Female Zebrafish via Matrix Metalloprotease-13 Inhibition |
| Cordyceps | 📋 | ✍ | ⛔ | | 40508211 | Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 40418820 | Effects of evening primrose oil on treating painful diabetic neuropathy: a randomized, double-blind, clinical trial |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38924882 | NMN synbiotics intervention modulates gut microbiota and metabolism in APP/PS1 Alzheimer's disease mouse models |
| Mushrooms | 📋 | | ⛔ | | 38474765 | Association between Intake of Edible Mushrooms and Algae and the Risk of Cognitive Impairment in Chinese Older Adults |
| Myrrh | 📋 | ✍ | ⛔ | | 40427076 | Effective Management of Chronic Low Back Pain in the Elderly: A One-Year Cohort Study of Oxygen-Ozone Therapy Under CT Guidance Combined with Alpha Lipoic Acid, Palmitoylethanolamide, and Myrrh |
| Sesamol | 📋 | | | | 39881218 | The prospective therapeutic benefits of sesamol: neuroprotection in neurological diseases |
| Shogaol | 📋 | | | | 40063144 | 6-Shogaol, a neuro-nutraceutical derived from ginger, alleviates motor symptoms and depression-like behaviors and modulates the release of monoamine neurotransmitters in Parkinson's disease mice |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 40506698 | The epigenetic potential of vitamin K2 in brain health |
| Wormwood | 📋 | ✍ | ⛔ | | 38893336 | In Vitro and In Silico Anti-Glioblastoma Activity of Hydroalcoholic Extracts of Artemisia annua L. and Artemisia vulgaris L |
| Acacetin | 📋 | | | | 36590896 | Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury |
| Astragalin | 📋 | | | | 40089077 | Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation |
| PQQ | 📋 | ✍ | ⛔ | | 40234255 | Current study on Pyrroloquinoline quinone (PQQ) therapeutic role in neurodegenerative diseases |
| Tannic Acid | 📋 | ✍ | ⛔ | | 38455638 | Tannic acid ameliorates the hazards effect of beryllium induced neuro-alterations and oxidative stress in adult male rats |
| Andrographis | 📋 | ✍ | ⛔ | | 38057817 | Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway |
| Dandelion | 📋 | ✍ | ⛔ | | 37746960 | External application of dandelion combined with borneol effectively reduced pain and facial swelling after jaw surgery |
| Dioscin | 📋 | | | | 40391080 | Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma |
| Fenugreek | 📋 | ✍ | ⛔ | | 40125337 | Anti-inflammatory and antioxidant effects of fenugreek in preventing mice model of Alzheimer's disease |
| Magnolia | 📋 | ✍ | ⛔ | | 38955265 | Neolignans in Magnolia officinalis as natural anti-Alzheimer's disease agents: A systematic review |
| Retinoic Acid | 📋 | | | | 39707779 | Short-term effects of retinoic acid on the proliferation of SH-SY5Y cells via mitophagy and apoptosis |
| SAMe | 📋 | ✍ | ⛔ | | 40156718 | SAM Alleviates Neuroinflammation by Regulating M1/M2 Polarization of Microglia Through α7nAChR/Nrf2/HO-1 Signaling Pathway |
| Balloon Flower | 📋 | ✍ | ⛔ | | 40333841 | Role of Saponins from Platycodon grandiflorum in Alzheimer's Disease: DFT, Molecular Docking, and Simulation Studies in Key Enzymes |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 38591965 | Caffeic acid attenuates memory dysfunction and restores the altered activity of cholinergic, monoaminergic and purinergic in brain of cadmium chloride exposure rats |
| Carnosol | 📋 | | | | 40465192 | Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease |
| Chamomile | 📋 | ✍ | ⛔ | | 40541754 | Matricaria Chamomilla L. Leaf and Flower Extracts Improved Scopolamine-Induced Amnesia Via Regulation of Cholinergic Dysfunction and Brain Antioxidant Status: An In-vivo and In-silico Study |
| Chokeberry | 📋 | ✍ | ⛔ | | 39456671 | The Protective Effect of the Supplementation with an Extract from Aronia melanocarpa L. Berries against Cadmium-Induced Changes of Chosen Biomarkers of Neurotoxicity in the Brain-A Study in a Rat Model of Current Lifetime Human Exposure to This Toxic Heavy Metal |
| Coptis Chinensis | 📋 | | ⛔ | | 40160459 | The potential role and mechanism of Rhizoma Coptidis in prevention of diabetic encephalopathy: targeting sodium ion and channels |
| Cyanidin | 📋 | ✍ | | | 40454491 | Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018 |
| D-Limonene | 📋 | ✍ | ⛔ | | 39460415 | Therapeutic potential of d-limonene in rheumatoid arthritis: Modulation of inflammatory, anti-inflammatory cytokines, and prostaglandin E2 |
| Elderberry | 📋 | ✍ | ⛔ | | 40225419 | Neuroprotective effects of the elderberry diet on the methamphetamine-induced toxicity in rats: a behavioral, electrophysiological, and histopathological study |
| Hawthorn | 📋 | ✍ | ⛔ | | 36447359 | Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model |
| Lavender | 📋 | ✍ | ⛔ | | 40378919 | Synergistic anticonvulsant activity of oregano, chamomile, and lavender via intranasal administration: A dose-response modeling approach |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 40137945 | Comparative efficacy of Mucuna pruriens and conventional levodopa in Parkinson's disease: a randomized controlled trial on pharmacokinetics and clinical perspectives from Asia |
| Pregnenolone | 📋 | ✍ | ⛔ | | 36878398 | Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease |
| Rhodiola | 📋 | ✍ | ⛔ | | 38398618 | Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review |
| Safranal | 📋 | | | | 38823659 | Safranal alleviates pentetrazole-induced epileptic seizures in mice by inhibiting the NF-κB signaling pathway and mitochondrial-dependent apoptosis through GSK-3β inactivation |
| Sesamin | 📋 | ✍ | | | 40142993 | Evaluation of the Antinociceptive Effect of Sesamin: Role of 5HT1A Serotonergic Receptors |
| Strawberry | 📋 | ✍ | ⛔ | | 38003966 | Amelioration of Rheumatoid Arthritis by Fragaria nubicola (Wild Strawberry) via Attenuation of Inflammatory Mediators in Sprague Dawley Rats |
| Tetrahydrocurcumin | 📋 | ✍ | | | 40332041 | The Role of Tetrahydrocurcumin in Tumor and Neurodegenerative Diseases Through Anti-Inflammatory Effects |
| Basil | 📋 | ✍ | ⛔ | | 39340486 | Long-term food supplementation with sweet basil (Ocimum basilicum L.) prevents age-associated cognitive decline in female mice |
| Black Pepper | 📋 | ✍ | ⛔ | | 37237954 | Black Pepper ( Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent against Neurodegenerative Diseases |
| Chondroitin | 📋 | ✍ | ⛔ | | 39490596 | Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms |
| Cornus | 📋 | | | | 40429970 | Network Pharmacology-Guided Evaluation of Ginger and Cornelian Cherry Extracts Against Depression and Metabolic Dysfunction in Estrogen-Deficient Chronic Stressed Rats |
| Diosmetin | 📋 | | | | 40482977 | Neuroprotection in spinal cord ischemia-reperfusion injury: Diosmetin's role via TREM2-mediated microglial pyroptosis |
| Eucommia | 📋 | ✍ | ⛔ | | 40141407 | Identification of Key Active Constituents in Eucommia ulmoides Oliv. Leaves Against Parkinson's Disease and the Alleviative Effects via 4E-BP1 Up-Regulation |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 40474979 | Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota |
| Guggulsterone | 📋 | | | | 38170440 | Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples |
| Haritaki | 📋 | ✍ | ⛔ | | 38734185 | Terminalia chebula attenuates restraint stress-induced memory impairment and synaptic loss in the dentate gyrus of the hippocampus and the basolateral and central nuclei of the amygdala by inhibiting oxidative damage |
| Lotus | 📋 | | ⛔ | | 39756059 | Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c-Jun Pathway |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 39990741 | The anti-depression effect and mechanism of harmonious rosemary essential oil and its application in microcapsules |
| Royal Jelly | 📋 | ✍ | ⛔ | | 38657030 | Comparative neuroprotective effects of royal jelly and its unique compound 10-hydroxy-2-decenoic acid on ischemia-induced inflammatory, apoptotic, epigenetic and genotoxic changes in a rat model of ischemic stroke |
| Sage | 📋 | ✍ | ⛔ | | 40266402 | A network pharmacology-based approach to decipher the pharmacological mechanisms of Salvia officinalis in neurodegenerative disorders |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 39984555 | Nebulized seabuckthorn seed oil inhalation attenuates Alzheimer's disease progression in APP/PS1 mice |
| Trans-Resveratrol | 📋 | | | | 40362855 | Neuroprotective Effects of a Combination of Dietary Trans-Resveratrol and Hesperidin Against Methylglyoxal-Induced Neurotoxicity in a Depressive Amnesia Mouse Model |
| Bergamot | 📋 | ✍ | ⛔ | | 39983332 | SIRT1: A likely key for future therapeutic strategies for pain management |
| Blackberry | 📋 | | ⛔ | | 38861649 | Blackberry extract prevents lipopolysaccharide-induced depressive-like behavior in female mice: implications for redox status, inflammation, and brain enzymes |
| Calcium | 📋 | ✍ | ⛔ | | 39287671 | Resveratrol enhances the protective effects of calcium supplements on spinal cord injury-induced osteoporosis by targeting the SIRT1/FOXO3a pathway |
| Coumaric acid | 📋 | | | | 38000530 | Protection of p-Coumaric acid against chronic stress-induced neurobehavioral deficits in mice via activating the PKA-CREB-BDNF pathway |
| Cryptotanshinone | 📋 | | | | 40345007 | Cryptotanshinone promotes ferroptosis in glioblastoma via KEAP1/NRF2/HMOX1 signaling pathway |
| Echinacea | 📋 | ✍ | ⛔ | | 36640914 | Evaluation of anti-Alzheimer activity of Echinacea purpurea extracts in aluminum chloride-induced neurotoxicity in rat model |
| Fiber | 📋 | ✍ | ⛔ | | 40101973 | Association of 15 common dietary factors with tinnitus: a systematic review and meta-analysis of observational studies |
| Glucosamine | 📋 | ✍ | ⛔ | | 37689747 | Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population |
| Honey | 📋 | ✍ | ⛔ | | 37570596 | Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids |
| Hypericin | 📋 | | | | 40384041 | Hypericin Regulates Inflammation Levels and Improves Depressive Symptoms in Rats With Post-Stroke Depression Through the MEK/ERK/CREB Pathway |
| Liquiritin | 📋 | | | | 39295943 | Liquiritin ameliorates painful diabetic neuropathy in SD rats by inhibiting NLRP3-MMP-9-mediated reversal of aquaporin-4 polarity in the glymphatic system |
| Nootkatone | 📋 | | | | 39819316 | Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway |
| Oleanolic Acid | 📋 | | | | 40537615 | Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson's disease treatment |
| Persimmon | 📋 | | ⛔ | | 40297616 | Diospyros lotus leaf extract and its main component, myricitrin, inhibit both histamine?dependent and histamine?independent itching |
| Phytoestrogens | 📋 | | ⛔ | | 39422947 | Alzheimer's Disease and (Phyto) Estrogen Treatment: Modification of Effects by Age, Type of Treatment, and Duration of Use |
| Roselle | 📋 | ✍ | ⛔ | | 40156811 | Effect of Aqueous Extract of Hibiscus Sabdariffa on Cadmium Chloride-Induced Neurotoxicity in Male Wistar Rats |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 39035497 | The protective effect of biotin supplementation and swimming training on cognitive impairment and mental symptoms in a rat model of Alzheimer's disease: A behavioral, biochemical, and histological study |
| Anethole | 📋 | | | | 40465192 | Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease |
| Betulinic Acid | 📋 | | | | 40388862 | Betulinic acid enhances autopahgy to promote microglial M2 polarization and alleviate inflammation via AMPK-HDAC5-KLF2 signaling pathways in spinal cord injury |
| Dihydroartemisinin | 📋 | | | | 39910679 | Therapeutic effect of dihydroartemisinin on Alzheimer's disease model mice with senile macular degeneration |
| Fruits | 📋 | | | | 40101973 | Association of 15 common dietary factors with tinnitus: a systematic review and meta-analysis of observational studies |
| Galangal | 📋 | ✍ | ⛔ | | 39408345 | Potential Neuroprotective Effects of Alpinia officinarum Hance (Galangal): A Review |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 32439412 | GAMMA-LINOLENIC ACID ALTERS MIGRATION, PROLIFERATION AND APOPTOSIS IN HUMAN AND RAT GLIOBLASTOMA CELLS |
| Horny Goat Weed | 📋 | ✍ | ⛔ | | 39018691 | Epimedium flavonoids improve cerebral white matter lesions by inhibiting neuroinflammation and activating neurotrophic factor signal pathways in spontaneously hypertensive rats |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 39844852 | Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice |
| Isorhamnetin | 📋 | | | | 39933950 | Isorhamnetin Alleviates Inflammation-Induced Crosstalk between Kynurenine Pathway and Gut Microbiota in Depressed Mice |
| Nattokinase | 📋 | ✍ | ⛔ | | 40302732 | Abnormal Expression of Proteolytic Stress-Related Proteins and Protective Effect of Fibrinolytic Enzymes in Prion Diseases |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 40158533 | Potential roles of inhalation aromatherapy on stress-induced depression by inhibiting inflammation in the peripheral olfactory system |
| Perilla | 📋 | ✍ | | | 40537890 | Effects of Perilla Seed Pomace Extract on Aging-Induced Cognitive Dysfunction in SAMP8 Mice |
| Procyanidins | 📋 | | ⛔ | | 39293861 | Procyanidin B1 Promotes PSMC3-NRF2 Ubiquitination to Induce Ferroptosis in Glioblastoma |
| Syringic Acid | 📋 | | | | 40354709 | Syringic acid alleviates cadmium-induced neurotoxicity in rats by modulating cellular signaling pathways |
| Theaflavins | 📋 | ✍ | | | 37324903 | Isolation and antioxidant characterization of theaflavin for neuroprotective effect in mice model |
| UDCA | 📋 | ✍ | ⛔ | | 39891787 | The effects of ursodeoxycholic acid on Parkinson's disease, a mechanistic review of the recent evidence |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 34564384 | Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson's Disease Dementia |
| Asparagus | 📋 | | ⛔ | | 40483633 | Exploration of Asparagus racemosus Willd for Alzheimer's Disease Through Integrated Metabolomics and Network Pharmacology Analyses Targeting BACE1 Protein |
| Bitter Melon | 📋 | ✍ | ⛔ | | 40450790 | Integrated in silico and GC-MS analysis of Momordica charantia Linn. phytocomponents against DiNP phthalate and B[a]P toxicity: A focus on amyloid beta protein and acetylcholinesterase in neurodegenerative disease |
| Black Tea | 📋 | ✍ | ⛔ | | 37483967 | Tea intake or consumption and the risk of dementia: a meta-analysis of prospective cohort studies |
| Boric Acid | 📋 | ✍ | ⛔ | | 37906374 | Boric acid Increases Susceptibility to Chemotherapy by Targeting the Ferritinophagy Signaling Pathway in TMZ Resistant Glioblastoma Cells |
| Cherry | 📋 | | ⛔ | | 36181653 | Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop |
| Clove | 📋 | | ⛔ | | 40149988 | Neuroprotective Properties of Clove (Syzygium aromaticum): State of the Art and Future Pharmaceutical Applications for Alzheimer's Disease |
| Coconut | 📋 | | ⛔ | | 31350628 | Phenolic rich Cocos nucifera inflorescence extract ameliorates inflammatory responses in LPS-stimulated RAW264.7 macrophages and toxin-induced murine models |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 39372701 | A dietary intervention with conjugated linoleic acid enhances microstructural white matter reorganization in experimental stroke |
| Cranberry | 📋 | ✍ | ⛔ | | 40442918 | Evaluation of Cranberry as a Novel Therapeutic Strategy for Intracerebroventricular (ICV) Quinolinic Acid-induced Cognitive Impairment in Rats |
| Fermented Foods | 📋 | | ⛔ | | 38280441 | Probiotic, prebiotic, synbiotic and fermented food supplementation in psychiatric disorders: A systematic review of clinical trials |
| GABA | 📋 | ✍ | ⛔ | | 38584977 | GABA Administration Ameliorates the Toxicity of Doxorubicin on CSF and the Brain of Albino Rats |
| Ginkgetin | 📋 | | | | 36836918 | Neuroprotective Potential of Biflavone Ginkgetin: A Review |
| Lauric Acid | 📋 | ✍ | | | 40418323 | Effects of lauric acid on cognitive impairment in a scopolamine-induced Alzheimer's disease-like rat model |
| Maca Root | 📋 | ✍ | ⛔ | | 39852155 | A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca Lepidium meyenii |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 39727960 | Assessment of Modified Citrus Pectin's Effects on Dementia in the Scopolamine-Induced Alzheimer's Model in Adult Male Wistar Rats |
| Patchouli | 📋 | ✍ | ⛔ | | 38996935 | The effect and mechanism of patchouli alcohol on cognitive dysfunction in AD mice induced by Aβ1-42 oligomers through AMPK/mTOR pathway |
| Phloretin | 📋 | | | | 39496685 | Phloretin attenuates inflammation induced by subarachnoid hemorrhage through regulation of the TLR2/MyD88/NF-kB pathway |
| Plum | 📋 | | ⛔ | | 37783584 | Plum-blossom needle therapy for Tourette syndrome: A case report |
| Soy | 📋 | ✍ | ⛔ | | 37818605 | Effect of dietary supplementation with multinutrient soy flour on body composition and cognitive function in elderly individuals at the risk of low protein: a randomized, double-blind, placebo-controlled study |
| Alpha GPC | 📋 | ✍ | ⛔ | | 38595916 | Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease |
| Anise | 📋 | ✍ | ⛔ | | 37755735 | Mechanistic Assessment of Anise Seeds and Clove Buds against the Neurotoxicity Caused by Metronidazole in Rats: Possible Role of Antioxidants, Neurotransmitters, and Cytokines |
| Atractylodes | 📋 | ✍ | ⛔ | | 38178130 | Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke |
| Barberry | 📋 | ✍ | ⛔ | | 39989392 | Identification of potential inhibitors of Fyn-Kinase from bioactive phytochemicals of Berberis lycium for therapeutic targeting of neurodegenerative disease |
| Chicoric Acid | 📋 | | | | 40123433 | Chicoric acid alleviates rotenone-induced motor dysfunction in mice: Targeting PI3K/AKT/caspase-3-associated apoptosis and neuroinflammation |
| Copper | 📋 | ✍ | ⛔ | | 37875826 | Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES) |
| Eleuthero | 📋 | ✍ | ⛔ | | 40332373 | Acanthopanax Senticosus Saponins Prevent Cognitive Decline in Rats with Alzheimer's Disease |
| Fig | 📋 | | ⛔ | | 38942739 | Ficus carica L. (Fig) promotes nerve regeneration in a mouse model of sciatic nerve crush |
| Genipin | 📋 | | | | 39565876 | Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration |
| Giloy | 📋 | ✍ | ⛔ | | 40057579 | Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer's disease |
| Krill Oil | 📋 | ✍ | ⛔ | | 40118278 | The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial |
| Liquiritigenin | 📋 | | | | 37005251 | Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice |
| Lupeol | 📋 | | | | 40279871 | Lupeol mitigates spinal cord injury by modulating microglial M1/M2 polarization via Na+/K+-ATPase-mediated mitophagy |
| Nuts | 📋 | | ⛔ | | 39343863 | Nut consumption is associated with a lower risk of all-cause dementia in adults: a community-based cohort study from the UK Biobank |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 39427538 | Soybean isoflavones protect dopaminergic neurons from atrazine damage by inhibiting VPS13A to increase autophagy |
| Tea Polyphenols | 📋 | | | | 40209346 | Effects of tea polyphenols and tea polysaccharides on improving nonylphenol-induced depression-like behavior, monoamine neurotransmitter disorder, and neuronal pyroptosis |
| Zingerone | 📋 | | | | 40535155 | Zingerone Attenuates Cadmium-Induced Neuroinflammation, Oxidative Stress and Cognitive Deficit on the Prefrontal Cortex of Adult Wistar Rats |
| Apple | 📋 | | ⛔ | | 34222062 | Effect of apple peel extract on diabetes-induced peripheral neuropathy and wound injury |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 38936553 | Anticonvulsant and anxiolytic-like potential of the essential oil from the Ocimum basilicum Linn leaves and its major constituent estragole on adult zebrafish (Danio rerio) |
| BCAA | 📋 | ✍ | ⛔ | | 38946582 | Branched-Chain Amino Acids Deficiency Promotes Diabetic Neuropathic Pain Through Upregulating LAT1 and Inhibiting Kv1.2 Channel |
| Berries | 📋 | | | | 39050136 | Study on the relationship between berry, grape, red wine consumption and cognitive impairment in middle-aged and elderly people in China |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 38142848 | Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice |
| Bilberry | 📋 | ✍ | ⛔ | | 40321611 | In Vitro Evaluation of Antidiabetic, Antioxidant, and Anticholinergic Properties of Different Parts of Bilberry (Vaccinium myrtillus L.) From the Eastern Black Sea Region, With LC/MS-MS Analysis of Their Chemical Composition in Food Applications |
| Blackcurrant | 📋 | ✍ | ⛔ | | 37110805 | The Flavonoid Rich Black Currant ( Ribes nigrum) Ethanolic Gemmotherapy Extract Elicits Neuroprotective Effect by Preventing Microglial Body Swelling in Hippocampus and Reduces Serum TNF-α Level: Pilot Study |
| Cardamom | 📋 | ✍ | ⛔ | | 39861065 | Multivalent Neuroprotective Activity of Elettaria cardamomum (Cardamom) and Foeniculum vulgare (Fennel) in H2O2-Induced Oxidative Stress in SH-SY5Y Cells and Acellular Assays |
| Cat's Claw | 📋 | ✍ | ⛔ | | 38310572 | Comprehensive In Silico Analysis of Uncaria Tomentosa Extract: Chemical Profiling, Antioxidant Assessment, and CLASP Protein Interaction for Drug Design in Neurodegenerative Diseases |
| Citral | 📋 | | | | 37244090 | Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats |
| Equol | 📋 | ✍ | ⛔ | | 39408343 | Equol Nonproducing Status as an Independent Risk Factor for Acute Cardioembolic Stroke and Poor Functional Outcome |
| Eucalyptol | 📋 | | | | 40205256 | Eucalyptol Attenuates Lead-Induced Anxiety-like Behaviors by Suppressing Oxidative Stress and Neuroinflammation, Modulating SIRT1/NF-?B Signaling, and Upregulating BDNF Expression |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 39374840 | Impacts of linseed oil diet on anxiety and memory extinction after early life stress: A sex-specific analysis of mitochondrial dysfunction, astrocytic markers, and inflammation in the amygdala |
| Ginger Essential Oil | 📋 | ✍ | | | 38106635 | The preventive effect of Zingiber officinale essential oil on demyelination of corpus callosum in a cuprizone rat model of multiple sclerosis |
| Hemp Oil | 📋 | ✍ | ⛔ | | 33722712 | Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain |
| Jasmine | 📋 | | ⛔ | | 40253129 | Jasmine tea extract prevents CUMS-induced depression-like behaviors through the modulation of microbiota-gut-brain axis |
| Kudzu Root | 📋 | ✍ | ⛔ | | 36232220 | Inhibition of LPS-Induced Microglial Activation by the Ethyl Acetate Extract of Pueraria mirifica |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 38963806 | Mitigation and mechanism of low dose linoleic acid on depression caused by disorder of gut microbiome |
| Neem | 📋 | ✍ | | | 39707776 | Influence of Azadirachta indica leaf extracts on tumor necrosis factor-α and interleukin-6 in albino rats and its computational analysis |
| Neohesperidin | 📋 | | | | 39751909 | Neohesperidin Improves Depressive-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mice |
| Nutmeg | 📋 | ✍ | ⛔ | | 35662922 | Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 39770894 | Dietary N-6 Polyunsaturated Fatty Acid Intake and Brain Health in Middle-Aged and Elderly Adults |
| Pelargonidin | 📋 | | | | 40196371 | Pelargonidin improves functional recovery and attenuates neuropathic pain following spinal cord injury in rats: relevance to its neuroprotective, antioxidant, and anti-inflammatory effects |
| Piperlongumine | 📋 | | | | 39692457 | Piperlongumine inhibits glioblastoma proliferation by inducing ferroptosis |
| Postbiotics | 📋 | | | | 40495829 | Potential clinical benefits of probiotics, prebiotics, synbiotics, and postbiotics for depression via the microbiota-gut-brain axis |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 36779860 | Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors |
| Shilajit | 📋 | ✍ | ⛔ | | 38073457 | Histopathological and immunohistochemical investigation of the effect of Shilajit in rats with experimental spinal cord injury |
| Spices | 📋 | | | | 40314109 | The analgesic effect and neural mechanism of spicy food intake |
| Vitamin K2 mk-4 | 📋 | ✍ | | | 38759366 | Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 39837405 | Vitamin K2 protects against D-galactose induced ageing in mice |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 39531579 | Inhibitory Potency of Chlorogenic Acid from Apple Cider Vinegar Against Alzheimer's Disease: Molecular Docking and Dynamics Validation |
| Asafoetida | 📋 | ✍ | ⛔ | | 40108916 | The Protective Effects of Ferula assa-foetida L. oleo-gum Resin on Diabetic Neuropathy in Animal Models |
| Beets | 📋 | ✍ | ⛔ | | 38887650 | Exploring beetroot (Beta vulgaris L.) for diabetes mellitus and Alzheimer's disease dual therapy: in vitro and computational studies |
| Beta-Cryptoxanthin | 📋 | | | | 37378145 | Diet as a Risk Factor for Rheumatoid Arthritis |
| Boron | 📋 | ✍ | ⛔ | | 40152096 | Protective Effect of Boric Acid on Oxidative Damage and Cognitive Function in Aging Modeled Rats |
| Cannabidiol Oil | 📋 | ✍ | ⛔ | | 33998856 | An Open Retrospective Study of a Standardized Cannabidiol Based-Oil in Treatment-Resistant Epilepsy |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 39560307 | Exploring the potential of Fargesin from Chrysanthemum indicum for chronic migraine: in-silico and pharmacokinetic study |
| Corn Silk | 📋 | ✍ | ⛔ | | 40460912 | Impact of Corn Silk Extract on paclitaxel-induced spinal cord and sciatic nerve injuries in rats: Biochemical and histological evaluation |
| Diallyl Disulfide | 📋 | | | | 37844463 | Diallyl disulfide attenuates pyroptosis via NLRP3/Caspase-1/IL-1β signaling pathway to exert a protective effect on hypoxic-ischemic brain damage in neonatal rats |
| DIM | 📋 | ✍ | ⛔ | | 39909809 | 3,3'-Diindolylmethane improves pathology and neurological outcome following traumatic brain injury |
| Frankincense Essential Oil | 📋 | | ⛔ | | 37783585 | The effect of back massage with frankincense and myrrh oil before the cardiac electrophysiological procedure on back pain intensity and comfort: A single-blind randomized controlled trial |
| Isoquercitrin | 📋 | | | | 38065271 | Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway |
| Knotweed | 📋 | ✍ | ⛔ | | 39909363 | Exploring the mechanism of Polygonum Cuspidatum in the treatment of ischemic stroke by network pharmacology analysis and experimental validation |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38489176 | Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease |
| L-Lysine | 📋 | ✍ | ⛔ | | 35696944 | Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study |
| Long Pepper | 📋 | | ⛔ | | 37821784 | The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction |
| Marjoram | 📋 | | ⛔ | | 39446705 | Analysis of Chemical Composition, Antioxidant Capacity, Acute Toxicity, and Antinociceptive Properties of Aqueous Extract of Origanum majorana L |
| Orange | 📋 | | ⛔ | | 39398602 | Navel orange peel ethanolic extract and naringin ameliorate CFA-induced arthritis in Wistar rats through their modulatory effects on Th1/Th2/Th17 cytokines and oxidative stress |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 35583855 | Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 38705428 | LC-qTOF-MS/MS phytochemical profiling of Tabebuia impetiginosa (Mart. Ex DC.) Standl. leaf and assessment of its neuroprotective potential in rats |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 39991095 | Pyridoxal 5'-phosphate and risk of stroke: triangulation of evidence from a nationally representative cohort and bidirectional Mendelian randomization analysis |
| Red Yeast Rice | 📋 | ✍ | ⛔ | | 36917811 | Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways |
| Safflower | 📋 | ✍ | ⛔ | | 40377982 | Protective effect of safflower oil supplementation on sciatic nerve crush injury in rats |
| Sirtuin Activators | 📋 | | | | 36306110 | SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders |
| Thyme | 📋 | ✍ | ⛔ | | 40283944 | Role of Thymus ciliatus (Thyme) to Ameliorate the Acute Neurotoxicity Induced by Bisphenol A: In Vivo Supported with Virtual Study |
| Thyme Essential Oil | 📋 | | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Wine | 📋 | | ⛔ | | 39458427 | The Potential Effects of Red Wine and Its Components on Neurocognitive Disorders: A Narrative Review |
| Almond | 📋 | | ⛔ | | 34832965 | The Inhibitory Effects of Terminalia catappa L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells |
| Anthocyanidins | 📋 | | | | 40454491 | Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018 |
| Apple Polyphenols | 📋 | | ⛔ | | 40386213 | Young apple polyphenol extract prevents diabetic cognitive dysfunction by promoting TET2-mediated active DNA demethylation in the brain of diabetic mice |
| Bay Leaf | 📋 | | ⛔ | | 36978994 | Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol |
| Beta-Lapachone | 📋 | | | | 39933959 | Neuroprotective Effect of β-Lapachone against Glutamate-Induced Injury in HT22 Cells |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 40429872 | INO10, a Chaga Mushroom Extract, Alleviates Alzheimer's Disease-Related Pathology and Cognitive Deficits in 3xTg-AD Mice |
| Cheese | 📋 | | ⛔ | | 38694223 | Association between cheese and fish consumption and the occurrence of depression based on European population: mediating role of metabolites |
| Cinnamic Acid | 📋 | | | | 35799788 | A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis |
| Clove Essential Oil | 📋 | | ⛔ | | 40012817 | The Effects of Aromatherapy With Clove and Lavender on Headache Caused by Spinal Anesthesia in Patients Undergoing Urological Surgery: A Randomized Clinical Trial Study |
| D-Mannose | 📋 | ✍ | ⛔ | | 35490896 | Mannose inhibits proliferation and promotes apoptosis to enhance sensitivity of glioma cells to temozolomide through Wnt/β-catenin signaling pathway |
| Dairy | 📋 | | | | 40101973 | Association of 15 common dietary factors with tinnitus: a systematic review and meta-analysis of observational studies |
| Date | 📋 | | ⛔ | | 36840284 | Neuroprotective Effect of Methanolic Ajwa Seed Extract on Lipopolysaccharide-Induced Memory Dysfunction and Neuroinflammation: In Vivo, Molecular Docking and Dynamics Studies |
| Diallyl Trisulfide | 📋 | | | | 37932742 | Diallyl trisulfide improves spinal cord ischemia-reperfusion injury damage by activating AMPK to stabilize mitochondrial function |
| Docosapentaenoic Acid | 📋 | ✍ | | | 39459191 | Protective Role of Eicosapentaenoic and Docosahexaenoic and Their N-Ethanolamide Derivatives in Olfactory Glial Cells Affected by Lipopolysaccharide-Induced Neuroinflammation |
| Eclipta Alba | 📋 | ✍ | | | 39535828 | Evaluation of the potential anti-arthritic effects and evaluation of acute oral toxicity of the active fraction of Eclipta prostrata leaves in rat model |
| Fennel | 📋 | ✍ | ⛔ | | 39861065 | Multivalent Neuroprotective Activity of Elettaria cardamomum (Cardamom) and Foeniculum vulgare (Fennel) in H2O2-Induced Oxidative Stress in SH-SY5Y Cells and Acellular Assays |
| Feverfew | 📋 | ✍ | ⛔ | | 38204302 | Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study |
| Glabridin | 📋 | | | | 40113986 | Glabridin as a selective Kv2.1 inhibitor ameliorates DPN pathology by disrupting the A?/Kv2.1/JNK/NF-?B/NLRP3/p-Tau pathway |
| Glycyrrhetinic Acid | 📋 | | | | 38964451 | Glycyrrhetinic Acid Triggers a Protective Autophagy by Inhibiting the JAK2/STAT3 Pathway in Cerebral Ischemia/Reperfusion Injury |
| HMB | 📋 | ✍ | ⛔ | | 38419348 | Muscle-building supplement β-hydroxy β-methylbutyrate stimulates the maturation of oligodendroglial progenitor cells to oligodendrocytes |
| Inulin | 📋 | ✍ | ⛔ | | 39287045 | Prebiotic inulin controls Th17 cells mediated central nervous system autoimmunity through modulating the gut microbiota and short chain fatty acids |
| Isoflavones | 📋 | ✍ | ⛔ | | 35740885 | Dietary Phytoestrogen Intake and Cognitive Status in Southern Italian Older Adults |
| Jujube | 📋 | | ⛔ | | 38562322 | Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models |
| Kiwifruit | 📋 | ✍ | ⛔ | | 34831142 | Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis |
| Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 38030022 | Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models |
| Lychee | 📋 | | ⛔ | | 33984432 | Pronounced anti-neuroinflammatory jasmonates and terpenes isolated from lychee seeds |
| Maitake Mushrooms | 📋 | | ⛔ | | 34071571 | Anti-Inflammatory and Immunomodulatory Effects of the Grifola frondosa Natural Compound o-Orsellinaldehyde on LPS-Challenged Murine Primary Glial Cells. Roles of NF-κβ and MAPK |
| Minerals | 📋 | | | | 40507121 | Actual Data on Essential Trace Elements in Parkinson's Disease |
| Nimbolide | 📋 | | | | 38036978 | In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma |
| Nuciferine | 📋 | | | | 40347924 | Nuciferine ameliorates blood-brain barrier disruption post-ischemic stroke via inhibiting the JAK2/STAT3 pathway |
| Onion | 📋 | ✍ | ⛔ | | 39594122 | Cooking Alters the Metabolites of Onions and Their Ability to Protect Nerve Cells from Lead Damage |
| Phosphatidylserine | 📋 | ✍ | ⛔ | | 35992593 | Phosphatidylserine, inflammation, and central nervous system diseases |
| Pomegranate Seed extract | 📋 | | ⛔ | | 35348947 | Amelioration of oxidative stress, cholinergic dysfunction, and neuroinflammation in scopolamine-induced amnesic rats fed with pomegranate seed |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 37400700 | Cucurbita pepo seeds improve peripheral neuropathy in diabetic rats by modulating the inflammation and oxidative stress in rats |
| Raspberry | 📋 | ✍ | ⛔ | | 38757671 | Raspberry Ketone Prevents LPS-Induced Depression-Like Behaviors in Mice by Inhibiting TLR-4/NF-κB Signaling Pathway via the Gut-Brain Axis |
| Rehmannia | 📋 | ✍ | ⛔ | | 39539631 | Rehmannia glutinosa DC.-Lilium lancifolium Thunb. in the treatment of depression: a comprehensive review and perspectives |
| Rose Essential Oil | 📋 | | | | 38688895 | A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats |
| Seafood | 📋 | | | | 39594554 | N-3 Fatty Acids in Seafood Influence the Association Between the Composite Dietary Antioxidant Index and Depression: A Community-Based Prospective Cohort Study |
| Seaweeds | 📋 | | ⛔ | | 40137277 | The Advancements of Marine Natural Products in the Treatment of Alzheimer's Disease: A Study Based on Cell and Animal Experiments |
| Sesame Oil | 📋 | | ⛔ | | 38548024 | The Protective Role of Sesame Oil against Parkinson's-Like Disease Induced by Manganese in Rats |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 40462659 | ??Functional Foods Alleviate Behavioral Alterations and Improve GABAergic System Regulating TLR-4/NF-?B Axis in Valproic-Induced Autism |
| Vegetables | 📋 | | | | 37405378 | Increased Intake of Vegetables and Fruits Improves Cognitive Function among Chinese Oldest Old: 10-Year Follow-Up Study |
| Whey Protein | 📋 | ✍ | ⛔ | | 39571910 | Effect of a 12-month intervention with whey protein powder on cognitive function in older adults with mild cognitive impairment: a randomized controlled trial |
| Aloin | 📋 | | | | 35421539 | Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 36904193 | Association between Arachidonic Acid and the Risk of Schizophrenia: A Cross-National Study and Mendelian Randomization Analysis |
| Arctiin | 📋 | | | | 39154088 | Arctiin Mitigates Neuronal Injury by Modulating the P2X7R/NLPR3 Inflammasome Signaling Pathway |
| Argan Oil | 📋 | ✍ | ⛔ | | 39408860 | Behavioral and Amygdala Biochemical Damage Induced by Alternating Mild Stress and Ethanol Intoxication in Adolescent Rats: Reversal by Argan Oil Treatment? |
| Artichoke | 📋 | ✍ | ⛔ | | 39320929 | Artichoke leaf hydroethanolic extract reduces neuropathic pain in a rat model of chronic constriction injury via attenuating the sciatic nerve oxidative stress |
| Avocado | 📋 | ✍ | ⛔ | | 39177142 | Exploring Potential Bioactive Components of Persea americana for the Treatment of Rheumatoid Arthritis through Network Pharmacology |
| Beta-Alanine | 📋 | ✍ | ⛔ | | 38971131 | β-Alanine supplementation improves fractional anisotropy scores in the hippocampus and amygdala in 60-80-year-old men and women |
| Bitter Orange | 📋 | ✍ | ⛔ | | 39760898 | Metabolomics analyses and comparative insight to neuroprotective potential of unripe fruits and leaves of Citrus aurantium ethanolic extracts against cadmium-induced rat brain dysfunction: involvement of oxidative stress and akt-mediated CREB/BDNF and GSK3β/NF-κB signaling pathways |
| Buckwheat | 📋 | | ⛔ | | 39019369 | Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and dysbiosis in AlCl3-treated rats |
| Burdock | 📋 | | ⛔ | | 34439529 | 1,3-Dicaffeoylquinic Acid as an Active Compound of Arctium lappa Root Extract Ameliorates Depressive-Like Behavior by Regulating Hippocampal Nitric Oxide Synthesis in Ovariectomized Mice |
| Cardamonin | 📋 | | | | 39673650 | Targeting Neuroinflammation and Apoptosis: Cardamonin's Cognitive Benefits in Alzheimer's 5XFAD Mice |
| Casein Protein | 📋 | ✍ | ⛔ | | 36245498 | The anti-anxiety/depression effect of a combined complex of casein hydrolysate and γ-aminobutyric acid on C57BL/6 mice |
| Cashew | 📋 | | ⛔ | | 38002521 | Cashew ( Anacardium occidentale) Extract: Possible Effects on Hypothalamic-Pituitary-Adrenal (HPA) Axis in Modulating Chronic Stress |
| Celery | 📋 | | ⛔ | | 40430359 | Exploring the Neuroprotective Properties of Celery (Apium graveolens Linn) Extract Against Amyloid-Beta Toxicity and Enzymes Associated with Alzheimer's Disease |
| Chlorella | 📋 | ✍ | ⛔ | | 37144207 | Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 39069079 | Neuroprotective effect of cinnamic alcohol: A bioactive compound of Cinnamomum spp. essential oil |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 32785956 | Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity |
| Costus | 📋 | ✍ | ⛔ | | 36451529 | Saussurea involucrata oral liquid regulates gut microbiota and serum metabolism during alleviation of collagen-induced arthritis in rats |
| Essential Amino Acids | 📋 | ✍ | ⛔ | | 34836128 | Deficiency in the Essential Amino Acids l-Isoleucine, l-Leucine and l-Histidine and Clinical Measures as Predictors of Moderate Depression in Elderly Women: A Discriminant Analysis Study |
| Eucalyptus | 📋 | ✍ | ⛔ | | 39486370 | Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer's disease |
| Fatty Acids | 📋 | | | | 36771380 | Dietary Fats and Depressive Symptoms in Italian Adults |
| Forskolin | 📋 | ✍ | ⛔ | | 36614135 | Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats |
| Geranium | 📋 | | | | 39921688 | Pelargonium graveolens Attenuates Rotenone-Induced Parkinson's Disease in a Rat Model: Role of MAO-B Inhibition and In Silico Study |
| Ginkgolic Acid | 📋 | | | | 39870805 | Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer's disease |
| Glutathione | 📋 | ✍ | ⛔ | | 38474196 | The Role of Glutathione in the Management of Cell-Mediated Immune Responses in Individuals with HIV |
| L-Alanine | 📋 | ✍ | ⛔ | | 33626855 | Extremely Low Serum Alanine Transaminase Level Is Associated with All-Cause Mortality in the Elderly after Intracranial Hemorrhage |
| L-Leucine | 📋 | ✍ | ⛔ | | 38382647 | Vcp overexpression and leucine supplementation extend lifespan and ameliorate neuromuscular junction phenotypes of a SOD1G93A-ALS mouse model |
| L-Methionine | 📋 | ✍ | ⛔ | | 39702349 | Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 35583855 | Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils |
| Lingonberry | 📋 | | ⛔ | | 40076984 | Revealing Lingonberry's Neuroprotective Potential in Alzheimer's Disease Through Network Pharmacology and Molecular Docking |
| Madecassoside | 📋 | | | | 38181970 | Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration |
| Malvidin | 📋 | | | | 40454491 | Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018 |
| Marjoram Essential Oil | 📋 | | ⛔ | | 38045619 | Inhalation of Origanum majorana L. essential oil while working reduces perceived stress and anxiety levels of nurses in a COVID-19 intensive care unit: a randomized controlled trial |
| Morusin | 📋 | | | | 39740503 | Morusin regulates the migration of M2 macrophages and GBM cells through the CCL4-CCR5 axis |
| MSM | 📋 | ✍ | ⛔ | | 35203043 | Methylsulfonylmethane protects against ethanol-induced brain injury in mice through the inhibition of oxidative stress, proinflammatory mediators and apoptotic cell death |
| Oolong Tea | 📋 | | ⛔ | | 35629970 | Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice |
| Oregano | 📋 | ✍ | ⛔ | | 40378919 | Synergistic anticonvulsant activity of oregano, chamomile, and lavender via intranasal administration: A dose-response modeling approach |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35354677 | Antinociceptive, anti-inflammatory, and cytotoxic properties of Origanum vulgare essential oil, rich with β-caryophyllene and β-caryophyllene oxide |
| Osmanthus | 📋 | ✍ | ⛔ | | 39554370 | The ethanolic extract of Osmanthus fragrans var. thunbergii flowers ameliorates depressive-like behaviors of mice by modulating the serotonin system and suppressing neuroinflammation |
| Papaya | 📋 | ✍ | ⛔ | | 40457195 | Antidepressant potential of Carica Papaya fruit extract and diet: behavioral and physiological effects in mice models |
| Pineapple | 📋 | ✍ | ⛔ | | 39219832 | Efficacy of a novel combination of aloe vera gel and pineapple extracts in improving post-extraction pain and healing: A Randomized Controlled Trial |
| Pistachio | 📋 | ✍ | ⛔ | | 40384990 | Therapeutic Potential of Pistachio Green Hull Extract in Treating Parkinson's Disease: A Comprehensive In Vivo and In Vitro Investigation |
| Poria Mushrooms | 📋 | ✍ | | | 40254847 | Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty Acids and Alleviate Neuroinflammation-Related Cognitive Impairment in Alzheimer's Disease |
| Potassium | 📋 | ✍ | ⛔ | | 37875826 | Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES) |
| Proanthocyanidins | 📋 | | | | 40025170 | Decoding the mechanism of proanthocyanidins in central analgesia: redox regulation and KCNK3 blockade |
| Protein | 📋 | ✍ | ⛔ | | 40406676 | The association of dietary protein intake in three meals and cognitive performance among people over sixty years old |
| Quercitrin | 📋 | | | | 36292931 | The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway |
| Shensong Yangxin | 📋 | ✍ | | | 32237459 | [Network Meta-analysis of randomized controlled trials of Chinese patent medicine for bradyarrhythmia] |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 31772594 | Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections |
| Toothache Plant | 📋 | | | | 35733629 | Promising Health Benefits of Adjuvant Acmella and Zingiber Extracts Combined with Coenzyme Q10 Phytosomes, Supplementation in Chronic Pain Treated with Medical Cannabis: A Prospective and Open-Label Clinical Study |
| Amygdalin | 📋 | ✍ | ⛔ | | 40081511 | Amygdalin's neuroprotective effects on acute ischemic stroke in rats |
| Arnica | 📋 | ✍ | ⛔ | | 40006537 | Anti-Inflammatory and Pain-Relieving Effects of Arnica Extract Hydrogel Patch in Carrageenan-Induced Inflammation and Hot Plate Pain Models |
| Black Ginger | 📋 | ✍ | ⛔ | | 40063637 | Kaempferia parviflora extract and its methoxyflavones as potential anti-Alzheimer assessing in vitro, integrated computational approach, and in vivo impact on behaviour in scopolamine-induced amnesic mice |
| Black Pepper Essential Oil | 📋 | | ⛔ | | 33997409 | Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum Linn. (Black pepper) in mice: involvement of serotonergic but not GABAergic transmission system |
| Citrus Fruits | 📋 | | ⛔ | | 35565814 | A Narrative Review of the Effects of Citrus Peels and Extracts on Human Brain Health and Metabolism |
| Collagen | 📋 | ✍ | | | 37551682 | Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults |
| GlyNAC | 📋 | ✍ | ⛔ | | 37975960 | The Effect of Glycine and N-Acetylcysteine on Oxidative Stress in the Spinal Cord and Skeletal Muscle After Spinal Cord Injury |
| Graviola | 📋 | ✍ | ⛔ | | 35485570 | Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis |
| Hazelnut | 📋 | | ⛔ | | 38151890 | Does hazelnut consumption affect brain health and function against neurodegenerative diseases? |
| Honeysuckle | 📋 | | ⛔ | | 39606633 | Revealing the potential therapeutic mechanism of Lonicerae Japonicae Flos in Alzheimer's disease: a computational biology approach |
| Horse Chestnut | 📋 | ✍ | ⛔ | | 39265741 | Sodium aescinate alleviates neuropathic pain through suppressing OGT-mediated O-GlcNAc modification of TLR3 to inactivate MAPK signaling pathway |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 37765216 | Hyaluronic Acid in Rheumatology |
| Iron | 📋 | ✍ | ⛔ | | 25837213 | Dietary intake of minerals in relation to depressive symptoms in Japanese employees: the Furukawa Nutrition and Health Study |
| L-Carnitine Tartrate | 📋 | ✍ | ⛔ | | 38672280 | Combined Metabolic Activators with Different NAD+ Precursors Improve Metabolic Functions in the Animal Models of Neurodegenerative Diseases |
| Lemon Verbena | 📋 | | ⛔ | | 35011093 | Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract |
| Lemongrass Essential Oil | 📋 | ✍ | ⛔ | | 33910044 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish |
| Limonin | 📋 | | | | 37536186 | Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats |
| Loquat | 📋 | ✍ | ⛔ | | 37513484 | Dried Loquat Fruit Extract Containing Chlorogenic Acid Prevents Depressive-like Behaviors Induced by Repeated Corticosteroid Injections in Mice |
| Mango Leaf | 📋 | | ⛔ | | 29557530 | Neuroprotective efficiency of Mangifera indica leaves extract on cadmium-induced cortical damage in rats |
| Marigold | 📋 | ✍ | ⛔ | | 38268908 | Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease |
| Matcha Tea | 📋 | | | | 39213264 | Effect of matcha green tea on cognitive functions and sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months |
| Neroli Essential Oil | 📋 | ✍ | ⛔ | | 40368523 | The effect of aromatherapy with Citrus Aurantium essential oil on depression, stress and anxiety in pregnant women; a randomized controlled clinical trial |
| Oats | 📋 | | ⛔ | | 34684684 | Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice |
| Okra | 📋 | | ⛔ | | 39862637 | Okra seed polysaccharides mitigate neuroinflammation and cognitive impairment via modulation of Nrf2/HO-1, HMGB1/RAGE/TLR4/NF-κB, NLRP3/Caspase-1, JAK-2/STAT-3, AMPK/SIRT1/m-TOR, PI3K/AKT/CREB/BDNF/TrkB and PERK/CHOP/Bcl-2 axes |
| Oleic Acid | 📋 | | ⛔ | | 34040528 | Combined Oral and Topical Application of Pumpkin ( Cucurbita pepo L.) Alleviates Contact Dermatitis Associated With Depression Through Downregulation Pro-Inflammatory Cytokines |
| Pantethine | 📋 | ✍ | ⛔ | | 39501296 | Coenzyme A fueling with pantethine limits autoreactive T cell pathogenicity in experimental neuroinflammation |
| Peanut | 📋 | | ⛔ | | 35418581 | Peanut (Arachis hypogaea) sprout prevents high-fat diet-induced cognitive impairment by improving mitochondrial function |
| Pear | 📋 | | ⛔ | | 34602398 | Determination of anxiolytic and antidepressant like activity of hydro alcoholic fruit extract of Pyrus communis (L.) and its impact on the memory after chronic dosing in animal models |
| Pectin | 📋 | ✍ | ⛔ | | 33618606 | Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain |
| Pumpkin | 📋 | | ⛔ | | 40254703 | Neuroprotective Effects of Cucurbita pepo Extract in Cuprizone-Induced Multiple Sclerosis Animal Model |
| Quinoa | 📋 | | ⛔ | | 38337665 | The Neuroprotective Role of Quinoa ( Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats |
| Rose | 📋 | | | | 38089182 | Neuroprotective Effects of Rosa damascena Extract against Aluminum Chloride-Induced Brain Damage in Rat Offspring |
| Rosehip | 📋 | ✍ | ⛔ | | 37088237 | Rosa canina L. improves learning and memory-associated cognitive impairment by regulating glucose levels and reducing hippocampal insulin resistance in high-fat diet/streptozotocin-induced diabetic rats |
| Sage Essential Oil | 📋 | | ⛔ | | 31618702 | HPTLC based approach for bioassay-guided evaluation of antidiabetic and neuroprotective effects of eight essential oils of the Lamiaceae family plants |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 26788112 | Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell |
| Serrapeptase | 📋 | ✍ | ⛔ | | 35694981 | The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach |
| Theobromine | 📋 | ✍ | ⛔ | | 37121724 | Comparing Effects of Caffeine and Theobromine on Adrenal Hypertrophy and Social Behavior in Psychosocial Stressed Mice |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 30574050 | Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 36826058 | Neurobiology and Applications of Inositol in Psychiatry: A Narrative Review |
| Vitex | 📋 | ✍ | ⛔ | | 36121091 | Potential Phytoconstituents of Genus Vitex for the Management of Rheumatoid Arthritis: A Review |
| Yiang Yiang Essential Oil | 📋 | | ⛔ | | 35551977 | Ylang-ylang (Cananga odorata (Lam.) Hook. f. & Thomson) essential oil reduced neuropathic-pain and associated anxiety symptoms in mice |
| Yogurt | 📋 | | ⛔ | | 39299595 | Association of probiotics, prebiotics, synbiotics or yogurt supplement with prevalence and all-cause mortality of depression: NHANES 2005-2016 |
| Apricot | 📋 | | ⛔ | | 36212969 | Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model |
| Avocado Oil | 📋 | | ⛔ | | 33480081 | Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules |
| Barley | 📋 | ✍ | ⛔ | | 36087390 | Effect of aqueous extract of barley and wheat grass in stress induced depression in Swiss mice |
| Bee Pollen | 📋 | ✍ | ⛔ | | 34774703 | Bee pollen increases hippocampal brain-derived neurotrophic factor and suppresses neuroinflammation in adult rats with chronic immobilization stress |
| Bergamottin | 📋 | | | | 33920139 | Bergamottin and 5-Geranyloxy-7-methoxycoumarin Cooperate in the Cytotoxic Effect of Citrus bergamia (Bergamot) Essential Oil in Human Neuroblastoma SH-SY5Y Cell Line |
| Brazil Nut | 📋 | | ⛔ | | 35052615 | Selenomethionine Ameliorates Cognitive Impairment, Decreases Hippocampal Oxidative Stress and Attenuates Dysbiosis in D-Galactose-Treated Mice |
| Broccoli | 📋 | | ⛔ | | 37839110 | The preventive effects of broccoli bioactives against cancer: Evidence from a validated rat glioma model |
| Cabbage | 📋 | | ⛔ | | 37781995 | Red Cabbage Anthocyanins Attenuate Cognitive Impairment By Attenuating Neuroinflammation and Regulating Gut Microbiota in Aging Mice |
| Camellia | 📋 | | ⛔ | | 40314670 | Insights into in silico analysis to explore the multitarget antidepressant role of Camellia sinensis |
| Camphor | 📋 | ✍ | ⛔ | | 36925623 | Camphor Attenuates Hyperalgesia in Neuropathic Pain Models in Mice |
| Castor Oil | 📋 | ✍ | ⛔ | | 34836854 | Antipyretic and antinociceptive potential of Ricinus communis L. and Withania somnifera L. hydroalcoholic extracts in Wistar rats: A comparative study |
| Chromium | 📋 | ✍ | ⛔ | | 40345207 | The Potential Benefits of Chromium and Selenium Supplementation Across Psychiatric Disorders and Symptoms |
| Delphinidin | 📋 | | | | 40542425 | Delphinidin attenuates cognitive deficits and pathology of Alzheimer's disease by preventing microglial senescence via AMPK/SIRT1 pathway |
| Egg | 📋 | | ⛔ | | 38782209 | Association of Egg Intake With Alzheimer's Dementia Risk in Older Adults: The Rush Memory and Aging Project |
| Essential Fatty Acids | 📋 | ✍ | | | 33337250 | Nutritional interventions for the prevention of cognitive impairment and dementia in developing economies in East-Asia: a systematic review and meta-analysis |
| Flaxseed | 📋 | ✍ | ⛔ | | 34837524 | The effect of flaxseed with or without anti-inflammatory diet in patients with rheumatoid arthritis, a randomized controlled trial |
| Garlic Oil | 📋 | | ⛔ | | 37435927 | Garlic essential oil ameliorates depression-like behaviors in unpredictable chronic mild stress by modulating the brain NLRP3 inflammasome pathway and influencing the gut barrier and microbiota |
| Geraniin | 📋 | | | | 39387398 | Anti-oxidant, anti-apoptotic and anti-inflammatory effects of geraniin in spinal cord injury in rat: role of COX-2 |
| Geranium Essential Oil | 📋 | | ⛔ | | 31490773 | Oral supplementation with geranium oil or anise oil ameliorates depressed rat-related symptoms through oils antioxidant effects |
| Glycine | 📋 | ✍ | ⛔ | | 39472117 | [Systematic evaluation of the correlation between serum metabolites and tinnitus] |
| Grape Seed Oil | 📋 | | ⛔ | | 32665902 | Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases |
| Grapefruit Essential Oil | 📋 | ✍ | ⛔ | | 35583855 | Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils |
| Guava | 📋 | | ⛔ | | 36934258 | Antiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection |
| Hops | 📋 | ✍ | ⛔ | | 35498911 | Discovery of 8-prenylnaringenin from hop ( Humulus lupulus L.) as a potent monoacylglycerol lipase inhibitor for treatments of neuroinflammation and Alzheimer's disease |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 36982577 | Novel Approach to the Treatment of Neuropathic Pain Using a Combination with Palmitoylethanolamide and Equisetum arvense L. in an In Vitro Study |
| Hyssop | 📋 | ✍ | ⛔ | | 36287300 | Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 35673507 | Protective effects of Labisia pumila against neuropathy in a diabetic rat model |
| L-Citrulline | 📋 | ✍ | ⛔ | | 33940559 | Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease |
| L-Histidine | 📋 | ✍ | ⛔ | | 36164730 | Histidine supplementation can escalate or rescue HARS deficiency in a Charcot Marie Tooth Disease model |
| Lemongrass | 📋 | ✍ | ⛔ | | 33910044 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish |
| Lettuce | 📋 | | ⛔ | | 35392648 | Lettuce as an Effective Remedy in Uremic Pruritus: Review of the Literature Supplemented by an In Silico Study |
| Manganese | 📋 | ✍ | ⛔ | | 35369103 | Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies |
| Mango | 📋 | | ⛔ | | 35344129 | Antidepressant activity of phytochemicals of Mangifera indica seeds assisted by integrated computational analysis |
| Mint | 📋 | | ⛔ | | 34916937 | Anti-Hyperalgesic Properties of Menthol and Pulegone |
| Myrrh Essential Oil | 📋 | | ⛔ | | 37783585 | The effect of back massage with frankincense and myrrh oil before the cardiac electrophysiological procedure on back pain intensity and comfort: A single-blind randomized controlled trial |
| Myrtle | 📋 | ✍ | ⛔ | | 30553998 | Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors |
| Omega-9 Fatty Acids | 📋 | | | | 34666393 | Selective Toxicity Effect of Fatty Acids Omega-3, 6 and 9 Combination on Glioblastoma Neurons through their Mitochondria |
| Parsley | 📋 | | ⛔ | | 34173678 | Investigation of possible neuroprotective effects of some plant extracts on brain in bile duct ligated rats |
| Peppermint | 📋 | ✍ | ⛔ | | 38625964 | Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities |
| Phellodendron | 📋 | ✍ | ⛔ | | 18426577 | Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial |
| Phytosterols | 📋 | | | | 38327787 | Cholesterol-metabolism, plant sterols, and long-term cognitive decline in older people - Effects of sex and APOEe4 |
| Pine Nut | 📋 | | ⛔ | | 37821052 | Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease |
| Psyllium | 📋 | ✍ | ⛔ | | 31103857 | Intake of Psyllium Seed Husk Reduces White Matter Damage in a Rat Model of Chronic Cerebral Hypoperfusion |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 39381131 | Cucurbita Pepo L. Seed Oil Modulates Dyslipidemia and Neuronal Dysfunction in Tramadol-Induced Toxicity in Wistar Albino Rats |
| Red Clover | 📋 | ✍ | ⛔ | | 40530523 | Red Clover Supplementation Alleviates Neurological Deficits in Estrogen Deficient Rats Exposed to Chronic Unpredictable Mild Stress |
| Rhubarb | 📋 | | ⛔ | | 38668344 | The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways |
| Rice | 📋 | | ⛔ | | 37375622 | Rice Germ Attenuates Chronic Unpredictable Mild Stress-Induced Muscle Atrophy |
| Rosavin | 📋 | | ⛔ | | 37758932 | Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer's disease activity in Wister rat model |
| Sesame | 📋 | ✍ | ⛔ | | 37539928 | Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 14572878 | Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells |
| Sorghum | 📋 | | ⛔ | | 38740315 | The identification of active compounds and therapeutic properties of fermented and non-fermented red sorghum for the treatment of Alzheimer's dementia |
| Soy Protein | 📋 | ✍ | ⛔ | | 39717252 | Protective Effect of Whey Protein Supplement Against Rotenone Induced Motor Dysfunction in a Rat Model of Parkinson Disease |
| Spearmint | 📋 | | ⛔ | | 40467024 | Spearmint extract Neumentix downregulates amyloid-β accumulation by promoting phagocytosis in APP23 mice |
| Sugarcane | 📋 | | ⛔ | | 35422173 | Flavonoids and fractions from Saccharum officinarum L. juice: antinociceptive agents and molecular docking evaluations with µ-opioid receptor |
| Sunflower Oil | 📋 | ✍ | ⛔ | | 39973828 | Exploring the mechanism of sunflower seed oil against Alzheimer's disease through experimental and network pharmacology studies |
| Tamarind | 📋 | | ⛔ | | 36002437 | Tamarindus indica ameliorates behavioral and cytoarchitectural changes in the cerebellar cortex following prenatal aluminum chloride exposure in Wistar rats |
| Terpenoids | 📋 | | | | 40403781 | Terpenoids: A promising traditional chinese medicine for neuropathic pain relief |
| Tomato | 📋 | | ⛔ | | 38016800 | Tomato and Lemon Extracts Synergistically Improve Cognitive Function by Increasing Brain-derived Neurotrophic Factor Levels in Aged Mice |
| Vitamin K1 | 📋 | ✍ | ⛔ | | 39533224 | Association of dietary vitamin K1 intake with epilepsy in adults in US: a cross-sectional study of National Health and Nutrition Examination Survey 2013-2018 |
| White Fungus | 📋 | | | | 40263235 | Tremella fuciformis Polysaccharides Alleviate Early Brain Injury in Experimental Subarachnoid Hemorrhage by Inhibiting the KDR-Mediated P38 MAPK/NF-?B Pathway |
| Xylitol | 📋 | ✍ | ⛔ | | 36154609 | Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice |
| Yerba Mate | 📋 | ✍ | ⛔ | | 40512339 | Caffeinated and Decaffeinated Yerba Mate (Ilex paraguariensis) Infusion Extracts Alter CD73 and Reduce the Migration and Adhesion of Glioblastoma Cells |
| Acemannan | 📋 | | | | 8680886 | Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease |
| Activated Charcoal | 📋 | ✍ | ⛔ | | 38146721 | Effects of Increased Blood Flow Rate and Oral Activated Charcoal on the Severity of Uremic Pruritus: A Randomized Crossover Clinical Trial |
| Alfalfa | 📋 | | ⛔ | | 32113847 | Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model |
| Aloesin | 📋 | | | | 38888378 | Aloesin ameliorates hypoxic-ischemic brain damage in neonatal mice by suppressing TLR4-mediated neuroinflammation |
| Amino Acids | 📋 | | | | 35471671 | The potential roles of amino acids and their major derivatives in the management of multiple sclerosis |
| Apricot Oil | 📋 | | ⛔ | | 39170485 | Analgesic effect of apricot kernel oil on neuropathic pain in rats |
| Arjuna | 📋 | ✍ | ⛔ | | 26195913 | Evaluation of analgesic activity of Terminalia arjuna (Roxb.) Wight and Arn bark: A tribal claim |
| Ashitaba | 📋 | ✍ | ⛔ | | 37403256 | The neuroprotective effects of Chalcones from Ashitaba on cuprizone-induced demyelination via modulation of brain-derived neurotrophic factor and tumor necrosis factor α |
| Bamboo | 📋 | ✍ | ⛔ | | 38334213 | The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model |
| Bell Pepper | 📋 | | ⛔ | | 34799309 | Analgesic and anti-inflammatory potential of four varieties of bell pepper (Capsicum annum L.) in rodents |
| Bile Salts | 📋 | | | | 39273226 | Emerging Roles of Bile Acids and TGR5 in the Central Nervous System: Molecular Functions and Therapeutic Implications |
| Bread | 📋 | | | | 38528644 | Sourdough bread as nutritional intervention tool for improvement of cognitive dysfunction in diabetic rats |
| Camphor Essential Oil | 📋 | | ⛔ | | 38621882 | [Essential oil of Cinnamomum camphora mitigates depression-like behavior in mice by regulating Nrf2/HO-1 pathway and inhibiting inflammatory cytokines] |
| Captopril | 📋 | | | | 26398443 | Effects of Curcumin and Captopril on the Functions of Kidney and Nerve in Streptozotocin-Induced Diabetic Rats: Role of Angiotensin Converting Enzyme 1 |
| Caraway | 📋 | | ⛔ | | 32113847 | Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model |
| Carbohydrates | 📋 | | | | 36539697 | Association of low-carbohydrate-diet score and cognitive performance in older adults: National Health and Nutrition Examination Survey (NHANES) |
| Cedarwood Essential Oil | 📋 | ✍ | ⛔ | | 32037737 | Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia |
| Chebulinic Acid | 📋 | | | | 37453379 | Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses |
| Chia Seeds | 📋 | | ⛔ | | 38104182 | Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways |
| Chickpea | 📋 | | ⛔ | | 28552514 | Aluminum-induced Molecular Neurodegeneration: The Protective Role of Genistein and Chickpea Extract |
| Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 32575103 | Effectiveness of Aromatherapy for Relief of Pain, Nausea, and Vomiting after Percutaneous Nephrolithotomy: A Randomized Controlled Trial |
| Cucumber | 📋 | | ⛔ | | 34354417 | Analgesic and anti-inflammatory effects and safety profile of Cucurbita maxima and Cucumis sativus seeds |
| Cumin | 📋 | | ⛔ | | 36601514 | Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats |
| DMAE | 📋 | ✍ | ⛔ | | 112632 | Dimethylaminoethanol (deanol): effect on apomorphine-induced stereotypy and an animal model of tardive dyskinesia |
| Durian | 📋 | | ⛔ | | 38956206 | Durian fruit pulp extract enhances intracellular glutathione levels, mitigating oxidative stress and inflammation for neuroprotection |
| Eucalyptus Essential Oil | 📋 | | ⛔ | | 31091506 | Analgesic effects of eucalyptus essential oil in mice |
| Fat | 📋 | | | | 36986159 | Dietary Fats and Cognitive Status in Italian Middle-Old Adults |
| Fir Needle Oil | 📋 | | ⛔ | | 36429972 | Relaxing Effects of Breathing Pseudotsuga menziesii and Lavandula angustifolia Essential Oils on Psychophysiological Status in Older Adults |
| Fish Collagen | 📋 | ✍ | ⛔ | | 35582851 | Structure of type II collagen from sturgeon cartilage and its effect on adjuvant-induced rheumatoid arthritis in rats |
| Fufang Danshen | 📋 | | | | 29770796 | Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease |
| Grapefruit | 📋 | | ⛔ | | 36500599 | Recovery of Naringin-Rich Flavonoid Extracts from Agroresidues with Anxiolytic- and Antidepressant-like Effects in Mice |
| Guggul | 📋 | ✍ | ⛔ | | 27548493 | Effects of Balsamodendron mukul Gum Resin Extract on Articular Cartilage in Papain-induced Osteoarthritis |
| Iodine | 📋 | ✍ | ⛔ | | 32802419 | The Relationship between Iodine and Selenium Levels with Anxiety and Depression in Patients with Euthyroid Nodular Goiter |
| Jasmine Essential Oil | 📋 | | | | 33723134 | In vitro cytotoxicity of cardamom oil, lemon oil, and jasmine oil on human skin, gastric, and brain cancer cell line |
| Jojoba Oil | 📋 | ✍ | ⛔ | | 33481197 | Ameliorative effects of jojoba oil on fipronil-induced hepatorenal- and neuro-toxicity: the antioxidant status and apoptotic markers expression in rats |
| Kale | 📋 | | | | 33540724 | Transepithelial Anti-Neuroblastoma Response to Kale among Four Vegetable Juices Using In Vitro Model Co-Culture System |
| Kava Root | 📋 | ✍ | ⛔ | | 11536390 | Kava and valerian in the treatment of stress-induced insomnia |
| Kimchi | 📋 | | ⛔ | | 35840231 | Kimchi intake alleviates obesity-induced neuroinflammation by modulating the gut-brain axis |
| L-Proline | 📋 | ✍ | ⛔ | | 27031721 | A Nutrient Mixture Inhibits Glioblastoma Xenograft U-87 MG Growth in Male Nude Mice |
| L-Threonine | 📋 | ✍ | ⛔ | | 33491030 | The Association between Dietary Amino Acid Intake and Cognitive Decline 8 Years Later in Japanese Community-Dwelling Older Adults |
| L-Tyrosine | 📋 | ✍ | ⛔ | | 10023508 | A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria |
| Laminaria | 📋 | ✍ | ⛔ | | 35394414 | Polysaccharides from laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation |
| Lemon | 📋 | | ⛔ | | 38016800 | Tomato and Lemon Extracts Synergistically Improve Cognitive Function by Increasing Brain-derived Neurotrophic Factor Levels in Aged Mice |
| Malva Sylvestris | 📋 | | ⛔ | | 32113847 | Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model |
| Mandarin | 📋 | | | | 33808343 | A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes |
| Metoprolol | 📋 | ✍ | ⛔ | | 36187012 | Baroreflex sensitivity predicts therapeutic effects of metoprolol on pediatric postural orthostatic tachycardia syndrome |
| Milk Thistle | 📋 | ✍ | ⛔ | | 38808323 | Effect of Silybum Marianum on Reduction of Chemotherapy-Induced Peripheral Neurotoxicity with Cisplatin |
| MUFA | 📋 | | ⛔ | | 16256248 | Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian Longitudinal Study on Aging |
| Mugwort | 📋 | | ⛔ | | 38893336 | In Vitro and In Silico Anti-Glioblastoma Activity of Hydroalcoholic Extracts of Artemisia annua L. and Artemisia vulgaris L |
| Mustard | 📋 | | ⛔ | | 34856751 | Anti-Parkinson's evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals |
| Myrtle Essential Oil | 📋 | ✍ | ⛔ | | 35596201 | Chemical composition, antibiofilm, cytotoxic, and anti-acetylcholinesterase activities of Myrtus communis L. leaves essential oil |
| Nitrate | 📋 | ✍ | ⛔ | | 39717927 | Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis |
| Noni | 📋 | | ⛔ | | 40304749 | Analgesic and neuroprotective effect of a lipid transfer protein isolated from Morinda citrifolia L. (noni) seeds on oxaliplatin-induced peripheral sensory neuropathy in mice |
| Oak Acorn | 📋 | ✍ | ⛔ | | 39408864 | Extraction Condition Optimization, Quantitative Analysis, and Anti-AD Bioactivity Evaluation of Acorn Polyphenols from Quercus variabilis, Quercus aliena, and Quercus dentata |
| Oak Gall | 📋 | ✍ | ⛔ | | 34961052 | Gallotannin-Enriched Fraction from Quercus infectoria Galls as an Antioxidant and Inhibitory Agent against Human Glioblastoma Multiforme |
| Olive | 📋 | ✍ | ⛔ | | 34796529 | Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke-induced depressive-like behaviors in Sprague-Dawley rats |
| Papain | 📋 | ✍ | ⛔ | | 32122870 | Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes |
| Parsnip | 📋 | | ⛔ | | 32700246 | Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study |
| Pecan | 📋 | | ⛔ | | 39929607 | Characterization of pecan, hickory, and walnut phospholipids and the comparable effects of pecan phospholipids with soy phospholipids on scopolamine-induced dementia in mice |
| Phosphatidylcholine | 📋 | ✍ | ⛔ | | 34819604 | Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress |
| Pine Needle Essential Oil | 📋 | ✍ | ⛔ | | 33655878 | Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus |
| Pomelo | 📋 | | ⛔ | | 33390110 | Pomelo Peel Volatile Oil Alleviates Neuroinflammation on Focal Cerebral Ischemia Reperfusion Injury Rats via Inhibiting TLR4/NF-κB Signaling Pathway |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 28472734 | Comparative in Silico Analyses of Cannabis Sativa, Prunella Vulgaris and Withania Somnifera Compounds Elucidating the Medicinal Properties Against Rheumatoid Arthritis |
| Rosehip Seed Oil | 📋 | | ⛔ | | 40158533 | Potential roles of inhalation aromatherapy on stress-induced depression by inhibiting inflammation in the peripheral olfactory system |
| Salt | 📋 | | ⛔ | | 35788204 | Role of no table salt on hypertension and stroke based on large sample size from National Health and Nutrition Examination Survey database |
| Sandalwood Essential Oil | 📋 | | ⛔ | | 35325869 | Aromatherapy Massage for Relief of Pruritus and Stress in Older Women |
| Scutellarein | 📋 | | | | 37239029 | A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease |
| Sea Cucumber | 📋 | | | | 40509464 | Sea Cucumber Hydrolysates Alleviate Cognitive Deficits in D-Galactose-Induced C57BL/6J Aging Mice Associated with Modulation of Gut Microbiota |
| Shugan Hewei Wan | 📋 | | | | 31602893 | [Effects of Shugan Hewei Decoction and active substance fractions on behavior and neurotransmitter levels in hypothalamus of depression model rats] |
| Sodium Bicarbonate | 📋 | ✍ | ⛔ | | 38838426 | Effects of sodium bicarbonate solution on hypergravity-induced Fos expression in neurons of the amygdala in rats: Implication of sodium bicarbonate therapy for vertigo |
| Spinach | 📋 | | ⛔ | | 30577447 | Effect of a Strawberry and Spinach Dietary Supplement on Spatial Learning in Early and Late Middle-Aged Female Rats |
| St. Johns Wort Oil | 📋 | | ⛔ | | 39840562 | Cytotoxic effects of Hypericum perforatum on Glioblastoma Cells by Inducing Oxidative Stress, Autophagy and Apoptosis |
| Star Anise | 📋 | ✍ | ⛔ | | 39452898 | Ultra-High-Performance Liquid Chromatography-High-Definition Mass Spectrometry-Based Metabolomics to Reveal the Potential Anti-Arthritic Effects of Illicium verum in Cultured Fibroblast-like Synoviocytes Derived from Rheumatoid Arthritis |
| Star Fuit | 📋 | | ⛔ | | 30196278 | Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease |
| Sweet Potato | 📋 | | ⛔ | | 35720655 | Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction |
| Tangerine | 📋 | | ⛔ | | 35100035 | Effects of Citrus depressa Hayata Fruit Extract on Thigh Muscles Mass and Composition in Subacute Stroke Patients: A Double-Blind, Randomized, Controlled Pilot Trial |
| Tea Polysaccharides | 📋 | | | | 40209346 | Effects of tea polyphenols and tea polysaccharides on improving nonylphenol-induced depression-like behavior, monoamine neurotransmitter disorder, and neuronal pyroptosis |
| Tea Tree Essential Oil | 📋 | | ⛔ | | 33468026 | Natural substances to potentiate canonical glioblastoma chemotherapy |
| Theabrownins | 📋 | | | | 33995088 | Theabrownin Induces Cell Apoptosis and Cell Cycle Arrest of Oligodendroglioma and Astrocytoma in Different Pathways |
| Turnip | 📋 | | ⛔ | | 30560075 | Analgesic Effect of Valerian Root and Turnip Extracts |
| Wasabi | 📋 | | ⛔ | | 35326132 | Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of Wasabia japonica |
| Wheat | 📋 | | ⛔ | | 34804895 | The effect of Triticum sativum (wheat) germ on postpartum pain: A double-blind clinical trial |
| White Mushrooms | 📋 | | ⛔ | | 36291298 | White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease |
| White Tea | 📋 | | ⛔ | | 21698507 | Neuroprotective effects of white tea against oxidative stress-induced toxicity in striatal cells |
| Wood Ear Mushrooms | 📋 | | ⛔ | | 31002628 | Role of Aqueous Extract of the Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), in Avoidance of Haloperidol-lnduced Catalepsy via Oxidative Stress in Rats |
| Yohimbine | 📋 | ✍ | | | 34889886 | Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments |
